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Re-puporsed drugs to treat NSCLC, ROS1-positive

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(@daniel)
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Joined: 9 years ago
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@j Thank you, Johan. Very interesting indeed.


   
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(@j)
Joined: 6 years ago
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@daniel yes, I now think chronic sub-toxic levels of ammonia play a major role in the entire cancer process, from initiation to progression. I've outlined a hypothesis here

 

 


   
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(@j)
Joined: 6 years ago
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(@j)
Joined: 6 years ago
Posts: 2160
 

Posted by: @j

Posted by: @dng050

Interesting. Any recommendations on dosage and brand? 

dng050

I'd make sure to get the purest citric acid, maybe a brand like bulk supplements, or sour salt that is 100% citric acid. A year ago I tested different dosages and felt a bit agitated at the higher doses, I think I was taking 4 grams when I felt a bit anxious. But that might have been because of the quality of the product I used.

https://synergiesforcancertreatments.blogspot.com/p/citric-acid.html

 

 

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling {ref}

"we reveal ammonium as a dose-dependent stimulator of proliferation"

"we show that ammonium triggers rapid and sensitive mTORC2-dependent phosphorylation of AKT-S473 in cancer cells. We show that the latter mTORC2 activation occurs via the PI3K pathway and relies on YES1 and FAK kinases, on integrin ITGβ1 and on calcium stores mobilization. In addition, our data indicate that ammonium also leads to an AKT-dependent stimulation of mTORC1 signaling and to a dose-dependent stimulation of proliferation. Our results thus identify the so-called ammonium waste as a signal impacting on mTORC2 and mTORC1 activity."

 

 


   
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