Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650324/

@loco0000 Hi Alex, yes you can e-mail me via the email on this website, contact section. Kind regards, Daniel

@j or @daniel or @manuone or anyone else - do you guys have any studies on Sodium phenylbutyrate and glioblastoma or cancer? i only found this that's a phase 1 and not that convincing - I am trying to make the pitch to my mom's doctor to put her on it and trying to figure out how to build the case

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871887/

also does it make sense to pair this with DCA? or it's redundant? in one place it seems like it's a good idea

https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/?highlight=phenylbutyrate

here it seems like they kind of do the same thing

https://www.cancertreatmentsresearch.com/community/brain-cancer/answer-to-manuel-on-phenylbutyrate/#post-699

Posted by: @loco0000

@j or @daniel or @manuone or anyone else - do you guys have any studies on Sodium phenylbutyrate and glioblastoma or cancer? i only found this that's a phase 1 and not that convincing - I am trying to make the pitch to my mom's doctor to put her on it and trying to figure out how to build the case

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871887/

 

also does it make sense to pair this with DCA? or it's redundant? in one place it seems like it's a good idea

https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/?highlight=phenylbutyrate

here it seems like they kind of do the same thing

https://www.cancertreatmentsresearch.com/community/brain-cancer/answer-to-manuel-on-phenylbutyrate/#post-699

Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate:

https://pubmed.ncbi.nlm.nih.gov/12241121/

PB is metabolized by the body and produces phenylacetylglutamine and phenylacetate also called antineoplastons A10 and AS2-1.

Toxicological study on antineoplastons A-10 and AS2-1 in cancer patients

https://pubmed.ncbi.nlm.nih.gov/8667595/

The effect of Antineoplaston, a new antitumor agent on malignant brain tumors

https://pubmed.ncbi.nlm.nih.gov/7474850/

Antineoplaston treatment for advanced hepatocellular carcinoma

https://pubmed.ncbi.nlm.nih.gov/9769368/

Long-Term Survival (23 Years) in a 26-Year-old Male after Antineoplaston Therapy for a Progressive, Diffuse Intrinsic Pontine Glioma: A Case Report

https://www.clinmedjournals.org/articles/ijbdt/international-journal-of-brain-disorders-and-treatment-ijbdt-7-038.php?jid=ijbdt

(note that Diffuse Intrinsic Pontine Glioma is the most deadly of all cancers and conventional treatment has never cured any of such patients ref)

I think you're idea of adding substances to try to enhance a therapeutic effect is excellent. Note that PB is very well tolerated. I don't see any downside to using it, I think it has about a 15 to 30% chance of producing a noticeable anticancer effect.

(*your idea)

Phase II study of antineoplaston A10 and AS2-1 in children with recurrent and progressive multicentric glioma : a preliminary report

https://pubmed.ncbi.nlm.nih.gov/15563234/

Sodium phenylbutyrate induces apoptosis in human retinoblastoma Y79 cells: the effect of combined treatment with the topoisomerase I-inhibitor topotecan

https://pubmed.ncbi.nlm.nih.gov/11351256/

Cancer or Tuberculosis: A Comprehensive Review of the Clinical and Imaging Features in Diagnosis of the Confusing Mass

https://www.frontiersin.org/articles/10.3389/fonc.2021.644150/full

Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578887/

Daniel has often referred to cancer as an infectious disease.

PB in combination with chemotherapy

Induction of Apoptosis in Malignant B Cells by Phenylbutyrate or Phenylacetate in Combination with Chemotherapeutic Agents

Clinical trials of these drugs as single agents indicate that they are not myelosuppressive; therefore, combinations with other chemotherapy agents may be possible.

https://aacrjournals.org/clincancerres/article/6/2/681/287991/Induction-of-Apoptosis-in-Malignant-B-Cells-by

Study show additive and in some case synergistic effects

The Effect of Antineoplastons A10 and AS2-1 and Metabolites of Sodium Phenylbutyrate on Gene Expression in Glioblastoma Multiforme

https://www.researchgate.net/publication/266558720_The_Effect_of_Antineoplastons_A10_and_AS2-1_and_Metabolites_of_Sodium_Phenylbutyrate_on_Gene_Expression_in_Glioblastoma_Multiforme

Thanks a lot @Johan - greatly appreciated. Sorry for the delay in reponse - Mom has been feeling iffy - she had some gastritis and she couldn't eat for a couple of days and has been throwing up. Now shes feeling better but she still throws up from time to time :(. We just started the 5 days of chemo.

Posted by: @loco0000

Thanks a lot @Johan - greatly appreciated. Sorry for the delay in reponse - Mom has been feeling iffy - she had some gastritis and she couldn't eat for a couple of days and has been throwing up. Now shes feeling better but she still throws up from time to time :(. We just started the 5 days of chemo.

I hope she feels better soon! Ginger tea (doesn't have to be fresh ginger, 1 gram of dried organic ginger powder in boiled water is OK) with a little lemon juice might help with nausea.

@j Johan - the ginger tea idea helped tremendously - thanks a lot my friend!

Posted by: @loco0000

@j Johan - the ginger tea idea helped tremendously - thanks a lot my friend!

wonderful! 

Take care,

J

hey guys ( @johan @daniel @manuone anyone else who might know)

any idea where i can buy  Sodium Phenylbutyrate ? 

also anybody had experience with boswelia infusion (as opposed to oral medication)?

Many thanks

@loco0000 Hi, please check this page on my blog:

https://synergiesforcancertreatments.blogspot.com/p/butyrate.html

I have a link to generic PB on there.

Hi @loco0000

https://www.canchema.com/ but I am not sure about the quality.  

Kind regards,
Daniel

thanks guys!