pH treatment strategy
Precisely, we propose using the association of eight pharmaceuticals (and a possible ninth) to achieve this goal:
- Lansoprazole or pantoprazole
- Amiloride or an analog of amiloride and cariporide could be another option
- Lipophilic statins like simvastatin, atorvastatin, cerivastatin and lovastatin
- Metformin or phenformin
- If the tumor overexpresses CA, acetazolamide should be added to the combination.
Each of these drugs has low toxicity at therapeutic doses. Except for cariporide, there is adequate experience with all of them, and they are FDA-approved. The drugs are inexpensive and require no phase I clinical trials. They can all be associated with conventional chemotherapy and radiotherapy.