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Off label medicine for PD-L1 expression NSCLC?

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mrmrva
(@mrmrva)
Joined: 11 months ago
Posts: 3
Topic starter  

I was not able to find anything on the topic so any info would be appreciated.

Father has stage IV NSCLC Adeno and first round of chemo did not yield any results. He now has met to adrenal gland and one rib. We got result of PD-L1 testing and his TPS score is 15% but at the moment he is not well enough to receive imunotherapy. Is there off label drug that we could use to take advantage of his PD-L1 expression?


   
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johan
(@j)
Joined: 4 years ago
Posts: 1191
 

not off label medicine but might be of interest

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140102/


   
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mrmrva
(@mrmrva)
Joined: 11 months ago
Posts: 3
Topic starter  

Thank you Johan, but if I understand this correctly EGFR+ is needed for this to work?

What we know so far is that father has EGFR and ALK negative tumor while PD-L1 is expressed.

I'll look into other articled regarding PD-L1 and NSCLC


   
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johan
(@j)
Joined: 4 years ago
Posts: 1191
 

My understanding is that even with low expression of egfr this could still lead to apoptosis via p53.

 


   
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Daniel
(@daniel)
Admin
Joined: 7 years ago
Posts: 1156
 
Posted by: @mrmrva

I was not able to find anything on the topic so any info would be appreciated.

Father has stage IV NSCLC Adeno and first round of chemo did not yield any results. He now has met to adrenal gland and one rib. We got result of PD-L1 testing and his TPS score is 15% but at the moment he is not well enough to receive imunotherapy. Is there off label drug that we could use to take advantage of his PD-L1 expression?

Hi Mrmrva,

 

Please read this https://www.cancertreatmentsresearch.com/rhus-verniciflua/

 

Kind regards,

Daniel


   
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johan
(@j)
Joined: 4 years ago
Posts: 1191
 
Posted by: @j

not off label medicine but might be of interest

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140102/

anticancer synergy with gallic acid

https://www.iosrjournals.org/iosr-jpbs/papers/Vol12-issue3/Version-6/I1203064852.pdf


   
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