LDN (low dose naltrexone)
I am surprised that I can not find a subject on LDN (low dose naltrexone) on this site. LDN as a cancer treatment was discovered by Dr. Bihari in the USA. Then resumed by Dr. Burt Berkson, Dr. Kahn in Canada and finally by the French doctor laurent schwartz who sometimes associates with its metabolic treatment (lipoic acid + gacinia cambodgia). The problem with LDN is that it is not compatible with morphine and that it often has results with patients who are still in good health. Dr. Bihari said he obtained the following results on 350 patients with different types of cancer. 20% for which he observed 75% tumor regression, 60% for which the disease stopped. LDN does not seem compatible with the use of chemo because it destroys the immune system. On the other hand, LDN has no side effects and is a well known and very cheap medicine.
Thanks a lot for the clear and to the point summary on LDN. LDN is one of those options I intend to address as soon as I have time. Yet, at this point my time is very limited since I have a full time job not related to oncology. My free time on the other hand is allocated with a higher priority responding e-mails of cancer patients in need and communicating with medical doctors and scientists. (I expect starting with this summer I will have much more time for oncology.) In this context, having people like you who are helping by contributing with own research is of very much help, and very much appreciated.
Please read my post on Immunomax - there I wrote shortly on when LDN should not be used in my opinion (and that is related to the TLR4 expression in cancers). https://www.cancertreatmentsresearch.com/immunomax-vaccine/
This was of course not a reproach Daniel. The work you have done is huge and incredible. But I was just surprised among all the treatments described on your site to not find trace of the LDN. His association with the metabolic treatment of Dr. Laurent Schwartz + ketogenic diet has sometimes yielded spectacular results.
But its impossible use with morphine unfortunately limits its use.
Off course I did not took it as a reproach. There are no traces about others that I intend to address. I would love to have more time to address all that I find relevant. And step by step I will.
In the mean time, like I said, I very much appreciate when visitors are also sharing their knowledge here. So whenever you learn something more about promising substances, please continue sharing. Thank you.
A good source for effectiveness of LDN is Dr. Dana Flavin.
Why do you think that Grant? Can you please give more details? Thanks.
After reading about LDN, it struck me that it is a well established worthwhile addition. Here is one link:
Regarding Dr. Dana Flavin, I was positively impressed with her credentials and past and present work. She has treated around 500 patients with LDN. Here is an audio interview where she talks about it. She believes it helps the immune system fight cancer by impacting Fox p3.
Here is the audio: https://vimeo.com/227861328
While sometimes debated, Naltrexone is known as a TLR4 antagonist and has also been patented for treatment of pain when combined with COX inhibitors such as Ibuprofen (Ref.).
In cancer, following a meta analysis, it has been suggested that TLR4 inhibition in solid tumors is beneficial (Ref.), which indeed suggests Naltrexone could add value for cancer patients.
Role of TLR4 as a prognostic factor for survival in various cancers: a meta-analysis http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path=24178&path=75994