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Experimental and computational analyzes reveal tumor vessel cooptation dynamics and optimal treatment strategies.  

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Manuone
(@manuone)
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01/05/2020 2:19 pm  

This seems very interesting

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377457/


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Daniel
(@daniel)
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01/05/2020 2:56 pm  

Very Intresting Manuel. Do you have in mind an inhibition of cooption? I will check when I find the time but first we need to understand what are the mechanisms to inhibit behind the cooption process. It requires some digging. If you find anything, please let me know.

This could be good in combo with anti-agiogenesis but also some other strategy I have in mind to address focused on nutrient depletion.

Kind regards,
Daniel


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Manuone
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01/05/2020 6:12 pm  

A good explanation for tumor resistance and increased invasion after antiangiogenic treatment such as bevacizumab.
A doubt arises from my ignorance:
Is this extrapolated to the rest of the antiangiogenic therapies or is it an effect of the antiangiogenic therapies based on anti VEGF?


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Manuone
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02/05/2020 2:05 pm  

https://www.sciencedaily.com/releases/2019/01/190130161629.htm
Article quote:

¨that the possibility that glioblastoma progression can only be stopped by combination therapies has important clinical implications. A previous study from his team identified a specific pathway - the Wnt signaling pathway - as a regulator of vessel co-option in glioblastoma, suggesting that drugs inhibiting that pathway could block co-option. The new model also predicts that targeting co-option before using antiangiogenic drugs would be a better strategy than administering both drugs simultaneously.

"With a number of agents that block Wnt signaling in clinical trials, our work provides the rationale for testing the proposed combination for glioblastoma, a uniformly fatal disease," says Jain, the Cook Professor of Radiation Oncology (Tumor Biology) at Harvard Medical School .
This is very revealing, inhibition of the Wnt signaling pathway may help decrease vascular cooptation of tumors.
I need to know if this can be extrapolated to any anti-angiogenic therapy or is it implicated only to anti-VEGF-based anti-angiogenic therapies
. <<<<<<<<<<<<<<< THE MILLION'S QUESTION
This is a possible list of Wnt inhibitors:
https://web.stanford.edu/group/nusselab/cgi-bin/wnt/inhibitors
This is a matter to work on!

 
kind regards

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Daniel
(@daniel)
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02/05/2020 2:51 pm  

@manuone

Hi Manuel,

Thanks. We discussed a lot of wnt inhibitors on this website and you are using one 🙂

Wnt inhibitors are for example: Salinomycin, Ivermectin, Pyrvinuim Pamoate, Niclosamide, Aspirin. Here is an older article I liked a lot when i came across this in 2016 indicating some more wnt inhibitors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963808/

I think you are already using one of the best, i.e. Salinomycin.

Kind regards,
Daniel

 

 


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Manuone
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02/05/2020 3:18 pm  

@daniel

Thanks Daniel, I definitely get lost with so many drugs and signaling routes!


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