Are We Covering All of Cancer's Primary Metabolic Pathways / Fuel Sources w/This Protocol (linked)?  

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Leora Caylor
(@leora-caylor)
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06/08/2018 2:53 pm  

Dear Daniel, I am so grateful I came across your fantastic website - dedicated to Mihaela. I am so sorry for your loss, but want to thank you for continuing to help people with all the knowledge you've gained through your painful experience. Cancer has impacted my family in many ways - and I stumbled across your website when I was researching HCA (Hydroxy Citrate) and Alpha Lipoic Acid. I found your article excellent! 

My mother is currently NED, after being diagnosed with a rare form of fallopian tube cancer in 2015 (undifferentiated carcinoma of the fallopian tube, originally thought to be carcinosarcoma). However, we want to maintain this by continuing with her very comprehensive integrative protocol. 
 
Although she received IV-Alpha Lipoic Acid more frequently early on, she now gets IV-ALA every other week, and takes ALA orally daily (600mg). Her doctor has recently suggested she add Hydroxy Citrate to this as well (forming the therapy called "Metabloc")... but my concern is that I want to make sure we are blocking all potential pathways of cancer with her supplement / therapy protocol, and not giving cancer stem cells (should there be any present) any opportunity to divert their fuel source. Your comments here were so interesting:
 
"When ACLYL is inhibited by HCA, tumor cells will express ACSS2 to convert acetate into the acetyl-CoA. ACSS2 level is modulated by SREBP2 and SREBP2 in turn can be modulated by Vitamin E derivates (tocotrienols specifically). In the clinical trials using HCA some people saw tumor reduction and after some time it came back. In that case, the escape mechanism may be explained by this... If that is the case, addition of ACSS2 inihibitors will solve the issue." 
 
This got me thinking... my mother is not currently including Tocotrienols in her protocol, but has added in Hydroxy Citrate. Should she add in Tocotrienols (have you, since writing this article, determined there is an even better option than Tocotrienols?), or do you feel the other supplements she is taking are acting in a pleiotropic way? Impacting many pathways, so her bases are covered? Should she have added in Hydroxy Citrate at all? 
 
Larger therapies:
IVC + IV-ALA (every other week now), combined with Liposomal Artemisinin and Berberine 
Mistletoe (Iscador P Series 2, subcutaneous)
Low Dose Naltrexone / CBD Oil (4 nights LDN, 3 nights CBD, repeat)
Far Infrared Sauna Therapy
Low Glycemic, Organic, High Vegetable Paleo Diet
 
And an extensive supplement protocol to complement the above (the same therapies are included in each, but just categorised differently):
Would you mind reviewing the protocol (linked above) to let me know if anything jumps out at you? My concern is that I want to make sure her protocol is very balanced, and that we aren't over-impacting one pathway, and not hitting another pathway, thereby giving cancer cells the opportunity to adjust their fuel source. The recent addition of HCA especially makes me want to fine tune things for her and wonder what we are missing... 
 
Thank you so much in advance!

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Daniel
(@daniel)
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06/08/2018 11:49 pm  

Dear Leora,

Thank you for your kind words. Regarding the questions, I will answer asap, this week.

Kind regards,
Daniel


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Leora Caylor
(@leora-caylor)
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Posts: 4
06/08/2018 11:50 pm  

Thank you so much Daniel! I really appreciate your time! 🙂


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Leora Caylor
(@leora-caylor)
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Posts: 4
15/08/2018 9:40 am  

Hi Daniel, absolutely no rush here - but just wanted to see if you'd had a chance to look over the protocol... my biggest questions are around HCA and making sure it's a good addition to her protocol, or that there aren't other considerations here. We HAVE since added Tocotrienols (Vitamin E), and D-Limonene, plus Holy Basil for its Ursolic Acid content. 


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Daniel
(@daniel)
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16/08/2018 1:18 am  

Dear Leora,

Thank you for your sensitive communication. I appologize for the delay but during the past days I was often on the phone (oncology related discussions) next to a full time job, and could not find time to respond.

I think you are doing a lot give the NED status of your mom. A good part of the supplements you are using I also addressed in various posts. One such post can be found here https://www.cancertreatmentsresearch.com/cancer-treatments/ So, in terms of supplements I do not have much to add.

The most important aspect to address when looking for prevention of recurrence is inflammation. We need to maintain a constant anti-inflammatory state. Next to the supplements addressing this point that you have already included (of which Omega 3 is one of the most relevant on this line), I would also consider low dose Aspirin (daily 100mg). To reduce the chance of cell adhesion, Cimetidine seems to be one of the most accessible and effective drugs. German clinics are giving it at 400mg/day up to 800mg/day for those with active disease. However, note that Cimetidine may interact with many drugs so whenever using a new drug in combo with Cim, the patient/doctor needs to check the interaction between the two. Diet also needs to be addressed (with a goal of maintaining a lower glucose level) but after seeing the nice YouTube video where you discuss foods, I expect you are addressing this aspect very well.

Regarding HCA, for prevention, there is not a strong need to add it. But if I would decide to add it, I would use it in cycles of several weeks. Again, I think addressing and maintaining a low level of inflammation is the key focus point at this moment.

Kind regards,
Daniel

This post was modified 4 days  ago by Daniel

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Daniel
(@daniel)
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16/08/2018 10:19 am  

One other supplement that I find very good to add with both prevention or active disease in mind, is Propolis BIO100 from Manuka. Other sources could also be good but I am not sure about the amount of active ingredients in other sources.

This post was modified 4 days  ago by Daniel

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Leora Caylor
(@leora-caylor)
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Posts: 4
16/08/2018 2:55 pm  

Thank you so much for your responses Daniel! 

And thank you for linking to the post you did... it looks like we are doing MANY of the things you're suggesting, so that was very reassuring for me. 

Re: Cimetidine: You mentioned Cimetidine as something to consider, and that was in your "metastases prevention" column on your linked article. Also in that column is Modified Citrus Pectin, which my mom DOES take. So I'm hoping some of those bases are covered for her already. 

Re: Aspirin: We have been on the fence with Aspirin because we've been told that the natural therapies my mom is already taking cover all the bases that Low Dose Aspirin would cover, without the side effects. But is that not true? Does Aspirin have a mechanism of action that's unique to it, not covered by the other inflammation-lowering, and COX2 inhibition supplements we are using? Can Aspirin be pulsed - one doctor suggested 1 week on, 1 week off, repeat... your thoughts? 

Re: HCA: So it sounds like we're not hurting anything by adding it to her mix, but you'd recommend we rotate it in and out? Like one month on, one month off? (We have added Tocotrienols and D-Limonene as well here, per recommendations in another post on this site, as approved by her doctor.)

Lastly:

- What are your thoughts on Vitamin B12 (as Hydroxo and Adenosylcobalamin) and Folate supplementation? So many very mixed messages out there about this - but my mom does take due to her genetic SNPs and elevated homocysteine.

- Two modalities that are widely recommended in cancer - Modified Citrus Pectin and Melatonin - oddly have been discouraged with ovarian cancer specifically. The MCP because of its galactose (?), and the Melatonin because old studies suggest there could be a problem. Have you seen any issues here, or are you aware of any problems? My mom takes both MCP and Melatonin. 


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