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A nice list of natural MDR inhibitors (P-Glycoprotein (P-gp) inhibitors)


Daniel
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Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152721/


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johan
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Epigallocatechin gallate and curcumin always show up, these substances are so versatile. 

 


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Daniel
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@johan I was looking for somebody with refractory H. Lymphoma for ways to increase Brentuximab effectiveness. It seems that one major resistance is due to MDR and if that is inhibited the response could be much better 
Inhibition of MDR1 Overcomes Resistance to Brentuximab Vedotin in Hodgkin Lymphoma https://clincancerres.aacrjournals.org/content/early/2020/01/17/1078-0432.CCR-19-1768  

But the patient may not be able to get on the drugs to inhibit MDR such as Verapamil, so the other option is to use natural supplements. I concluded that I would first go for the combo of Curcumin, EGCG, Quercetin in high doses. If not effective enough, I would switch to Artemisia Annua, Milk Thilste (Silymarin), Astragalus combo. All MDR inhibitors.

Kind regards,
Daniel


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johan
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@daniel

what dosages are you looking to use for CURC, EGCg and Que?

 


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Daniel
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@johan I would always do my best to go to doses that have been reported in case reports as effective, such as 7-8g Curcumin (Curcuminoids), 3-4g EGCG, several grams Quercetin. Of course, its possible that by using the 3 of them together synergy effects may be obtained and lower dose could be enough. In order to get to these doses, I would start from 25% target dose and move up step by step during e.g. 2 weeks. I would watch the liver enzymes due to EGCG higher dose. I would watch blood pressure that may slightly go down due to Curcumin high dose. I would take care if they are combined with blood thinners.

Kind regards,
Daniel


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Manuone
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@daniel

Very good point Daniel! I discussed a few months ago about a similar article ... It's just what I'm looking for ... pro-oxidant pre-therapy, p-glycoprotrein inhibitors and lomustine in small doses in liposomal form + large doses of DHA ...
We can try high doses of curcumin the same day of chemotherapy but this can be a risk as it is not clear if it interacts in an antioxidant way!


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Inabari
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@daniel once again, very interesting 


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Daniel
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@manuone hey Manuel, this may be a good reason why Curcumin is done alternating with chemo and radio in German clinics with positive results. So you could think about using sometimes the intravenous option since you have access to it. They have it at Burg Apo in Germany.

Kind regards,
Daniel


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