Good morning,
For months I have been delighted with the amount of work put into developing this site, but there is so much knowledge here that I am not able to handle it alone.
Mom has been suffering from ovarian cancer since December 2019. Initially, she underwent hysterectomies and platinum chemo. Since then, she had at most 4 months without chemotherapy (caeylyx, topotecan, etoposide). We tried different methods but none of the professional protocol. At the worst moment, there were metastases to the bones, lungs, adrenal glands, intestines.
At this point, the peritoneum and liver are involved. Under the supervision of an eminent doctor in Poland, we used salinomycin once a week but metastases appeared, for 4 months we have been using curcumin once a week, ivermectin 3x12mg / day, omeprazole, dca, metformin, tudca, aspirin (acard75mg) + (plus side supplements) in parallel with etoposide but still growing. Daniel and other experienced users, are there any new reliable protocols related to ovarian cancer? We also used the intravenous "protocol" from a dr from Germany - quercetin, vitamin c, thymus, actovegin, curcumin with infusions once a week, but despite the use, metastases appeared. Mom also used fenbendazole with the happyhealing protocol for 8 months along with caeylyx and then topotecan but then liver metastasis appeared so we decided it wasn't working. Please advise what to do next.
Greetings!
Good morning,
For months I have been delighted with the amount of work put into developing this site, but there is so much knowledge here that I am not able to handle it alone.
Mom has been suffering from ovarian cancer since December 2019. Initially, she underwent hysterectomies and platinum chemo. Since then, she had at most 4 months without chemotherapy (caeylyx, topotecan, etoposide). We tried different methods but none of the professional protocol. At the worst moment, there were metastases to the bones, lungs, adrenal glands, intestines.
At this point, the peritoneum and liver are involved. Under the supervision of an eminent doctor in Poland, we used salinomycin once a week but metastases appeared, for 4 months we have been using curcumin once a week, ivermectin 3x12mg / day, omeprazole, dca, metformin, tudca, aspirin (acard75mg) + (plus side supplements) in parallel with etoposide but still growing. Daniel and other experienced users, are there any new reliable protocols related to ovarian cancer? We also used the intravenous "protocol" from a dr from Germany - quercetin, vitamin c, thymus, actovegin, curcumin with infusions once a week, but despite the use, metastases appeared. Mom also used fenbendazole with the happyhealing protocol for 8 months along with caeylyx and then topotecan but then liver metastasis appeared so we decided it wasn't working. Please advise what to do next.Greetings!
Sorry to hear about your mom's situation. You have tried so many different options already and apparently, nothing has helped. Involvement of the peritoneum, liver, and lungs is typical of ovarian cancer and is why metastasis is so hard to deal with.
I'm not aware of any protocol for ovarian cancer specifically, you have tried many of the popular anticancer protocols, vitamin C, fenben, ivermectin, some variation of the COC protocol etc.
I would focus on metastasis, ovarian cancer is a vascular endothelial growth factor (VEGF) driven tumor.
A few options:
Theobromine
https://pubmed.ncbi.nlm.nih.gov/9468592/
https://www.sciencedirect.com/science/article/pii/S0753332220313330
Theobromine suppresses angiogenic activity of tumor cells
E. Barcz et al
"Angiogenesis plays the crucial role in growth of solid tumors and metastasis
formation. The aim of present study was to evaluate if theobromine, adenosine
receptor antagonist and phosphodiesterase inhibitor, shows antiangiogenic
activity in human tumor cells. Material was obtained from 59 patients with
kidney, bladder, lung or ovarian cancers. Full suspensions of tumor cells, or
isolated by immune magnetic separation (CD45 ab) infiltrating leukocytes and
cancer cells were grafted intradermally into Balb/c mice. Theobromine was
administered s.c. for three days (5 mg/kg) or cells were preincubated with the
drug (20 ng/ml) for 1,5 or 48 hours before grafting. In some experiments cells
were grafted intraperitoneally and after 48 hours harvested for proangiogenic
cytokines examination (by Elisa method).
Three days after intradermal cell grafting mice were sacrificed and newly
formed blood vessels counted in dissection miroscope (Sidky and Auerbach).
In all experiments we showed strong inhibitory effect of theobromine on angiogenesis.
We also showed significant inhibition of VEGF, and in some experiments significant
inhibition of bFGF and IL-8 production. Experiments with
antagonists of adenosine receptors (8PT and DPCPX) revealed, that angiogenesis
suppression is mediated through A2 receptors."
Theobromine + theanine may work synergistically.
bulk supplements dot com sells pure theobromine. It is important to note that theobromine can be toxic in large doses and should only be used under the guidance of a healthcare professional.
Viscum album (mistletoe)
Case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407985/
Ginger
Grape seed extract
Ginkgo Biloba
In addition, I'd use a combination of supplements and repurposed drugs.
mTOR, FAK and HER2 inhibition seem relevant in OC.
https://www.mushroomnutrition.com/ myconutri-antrodia-60-vegetarian-capsules.html
Cryptotanshinone Inhibits Ovarian Tumor Growth and Metastasis by Degrading c-Myc and Attenuating the FAK Pathway.
Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells.
Honokiol + Magnolol https://phcogj.com/article/975
Orlistat, a novel potent antitumor agent for ovarian cancer: proteomic analysis of ovarian cancer cells treated with Orlistat
https://pubmed.ncbi.nlm.nih.gov/22581080/
Lycopene
"Lycopene decreased the expression of the ovarian cancer biomarker, CA125. The anti-metastatic and anti-proliferative effects were accompanied by down-regulated expression of ITGA5, ITGB1, MMP9, FAK, ILK and EMT markers, decreased protein expression of integrin α5 and reduced activation of MAPK."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489781/
Green Tea: Green tea consumption enhances the survival of epithelial ovarian cancer. "There were 81 (77.9%) of 104 tea-drinkers who survived to the time of the interview, compared to only 67 women (47.9%) still alive among the 140 non-drinkers."
Artemisinin derivatives inhibit epithelial ovarian cancer cells via autophagy-mediated cell cycle arrest
Beta-Caryophyllene Suppresses Ovarian Cancer Proliferation by Inducing Cell Cycle Arrest and Apoptosis
Good morning,
For months I have been delighted with the amount of work put into developing this site, but there is so much knowledge here that I am not able to handle it alone.
Mom has been suffering from ovarian cancer since December 2019. Initially, she underwent hysterectomies and platinum chemo. Since then, she had at most 4 months without chemotherapy (caeylyx, topotecan, etoposide). We tried different methods but none of the professional protocol. At the worst moment, there were metastases to the bones, lungs, adrenal glands, intestines.
At this point, the peritoneum and liver are involved. Under the supervision of an eminent doctor in Poland, we used salinomycin once a week but metastases appeared, for 4 months we have been using curcumin once a week, ivermectin 3x12mg / day, omeprazole, dca, metformin, tudca, aspirin (acard75mg) + (plus side supplements) in parallel with etoposide but still growing. Daniel and other experienced users, are there any new reliable protocols related to ovarian cancer? We also used the intravenous "protocol" from a dr from Germany - quercetin, vitamin c, thymus, actovegin, curcumin with infusions once a week, but despite the use, metastases appeared. Mom also used fenbendazole with the happyhealing protocol for 8 months along with caeylyx and then topotecan but then liver metastasis appeared so we decided it wasn't working. Please advise what to do next.Greetings!
Dear,
I am sorry to hear about all these challenges.
There are many repurposed drugs and supplements that I woudl still consider, some of which Johan has listed above. However, it is clear that at this point you need a therapy that has proven effective in such cases as you describe.
The following options come to my mind in this case:
1. Insulin Potentiating Therapy (IPT) in combo with e.g. metronomic 2DG etc - such an option has led to great results in cases as you described - there are various clinics doing such treatments and one that I specifically recommend (I have nothing to gain from such a recommendation) is this clinic in Romania https://www.imuno-medica.ro/ They have some of the lowest prices in EU as the clinics is made from donations to help people, and it is now the largest integrative clinic I know in EU
2. Taurolidine - I did know a lady with advanced ovarian cancer responding very well - nearly complete remission - that was done at a clinic in Germany - the first one on this list https://www.cancertreatmentsresearch.com/clinics/ - the doctor is Polish of origin - I don't know if she is still doing it, but you could check with the doctor. Otherwise you can check the clinics from Romania as they may do it as well
I wrote about Taurolidine many years ago https://www.cancertreatmentsresearch.com/taurolidine/
3. Diflunisal could be another one that can lead to very good results - it is done at a clinic in Germany at Prof Drevs but very expensive
4. Silver nanoparticles - very easy to make at home and with great potential for systemic response https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/
There are many other options but I hope this already gives some ideas.
Regarding Salinomycin, one time per week sounds like very low frequency. It may also be important what type of Salinomycin has been used, how much and in how long time it has been administered during the IV day, as well as in combo with what.
Kind regards,
Daniel
Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
https://pubmed.ncbi.nlm.nih.gov/18025280/
"When combined with rapamycin, however, bevacizumab reduces tumor growth by
94% and significantly prolongs survival. Indeed, the
combination of BEV/RAPA induces a significant decrease
in the number of proliferating cells, the mean of Ki-67 –
positive cells, the mean vessel density, and ascites formation
and inhibited tumor cells from disseminating to internal
organs to a greater degree than single-agent therapy; all
these are associated with prolongation of survival compared
with control and monotherapy. The BEV/RAPA combined
protocol not only prevented tumor development in 40% of
mice but also induced an additive effect, including inhibition
of phosphorylation of S6R at Ser235/236 and p70S6 at Thr389
(Fig. 1A) and reduction in VEGF expression (Supplementary
Fig. S4).3 In addition, hypoxic cells and expression of
hypoxic inducible genes, such as VEGF and HIF-1a, are
significantly reduced in both rapamycin-and BEV/RAPAtreated mice (P < 0.01). These observations agree with a
previous study (32) showing that rapamycin enhanced
proteolytic degradation of HIF-1a, a transcription that
drives VEGF expression."
Thank you very much for your interest. Unfortunately, the etoposide didn't work and there is a slight increase but no new metastases. Changing to gemcitabine. What's the best way to boost the effect in addition to salinomycin a few days after? Can you please advise on the best oral supplementation/protocol? The liver is occupied but the results are normal. There is a pleural effusion, drainage of 3L of fluid, but the lungs are clear. Is it worth using cimetidine?
Thank you very much for your interest. Unfortunately, the etoposide didn't work and there is a slight increase but no new metastases. Changing to gemcitabine. What's the best way to boost the effect in addition to salinomycin a few days after? Can you please advise on the best oral supplementation/protocol? The liver is occupied but the results are normal. There is a pleural effusion, drainage of 3L of fluid, but the lungs are clear. Is it worth using cimetidine?
Thank you very much for your interest. Unfortunately, the etoposide didn't work and there is a slight increase but no new metastases. Changing to gemcitabine. What's the best way to boost the effect in addition to salinomycin a few days after? Can you please advise on the best oral supplementation/protocol? The liver is occupied but the results are normal. There is a pleural effusion, drainage of 3L of fluid, but the lungs are clear. Is it worth using cimetidine?
