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X-Ray PDT with Acridine Orange

Joined: 5 years ago
Posts: 549
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I have been interested for some time in this very powerful treatment concept of X-Ray PDT treatment. The ability to treat with a radio-sensitizer and then use body penetrating X-Rays has great intuitive appeal.

Acridine Orange might accomplish this.

AO has been used in a restricted sense to treated cancer for many years. 22360555

Yet, the in vivo safety of iv dosing has not been established in humans, though it has been in mice.

Recently a novel exosome formulation was developed that might permit human doses. 28262028

It is quite remarkable to realize that a simple molecule such as AO might allow for existing X-Ray treatment to target cancer cells anywhere in the body, likely with some selectivity.