X-Ray PDT with Acridine Orange
I have been interested for some time in this very powerful treatment concept of X-Ray PDT treatment. The ability to treat with a radio-sensitizer and then use body penetrating X-Rays has great intuitive appeal.
Acridine Orange might accomplish this.
AO has been used in a restricted sense to treated cancer for many years. 22360555
Yet, the in vivo safety of iv dosing has not been established in humans, though it has been in mice.
Recently a novel exosome formulation was developed that might permit human doses. 28262028
It is quite remarkable to realize that a simple molecule such as AO might allow for existing X-Ray treatment to target cancer cells anywhere in the body, likely with some selectivity.