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Cáncer etiology


Yudaitheska
(@yudaitheska)
Joined: 3 years ago
Posts: 32
Topic starter  

This is a very comprehensive paper about the etiology of cancer. Understanding helps us to be less affraid

Cáncer etiology: A metabolic disease originating from life's major evolutionary transition?

https://www.hindawi.com/journals/omcl/2019/7831952/


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Yudaitheska
(@yudaitheska)
Joined: 3 years ago
Posts: 32
Topic starter  

On the origin of metastases from mesenchymal cells (macrophages). 

Mitochondria are dynamic organelles that undergo regular fusion and fissions; thus abnormalities in mitochondrial lipid composition would be rapidly disseminated throughout the cell's mitochondrial network and could also be passed along to other cells through cytoplasmic inheritance during cellular fusion events.

Chronic inflammation increases fusion events. 

The formation of cancer cell and macrophage fusion hybrids would result in the transfer of damaged mitochondria from the cancer cell to the macrophage hybrid daughter cell. 

https://link.springer.com/article/10.1007/s10555-010-9254-z


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