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Adjuvant therapies are often approved based on composite, surrogate endpoints with high costs per event averted

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johan
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A total of 11 approvals were included in the analysis. During analyzed period, all approvals were based on a surrogate endpoint with no studies demonstrating, to date, an overall survival benefit. The median cost per event averted of drugs in the adjuvant setting was 1 610 000 USD (range, 820 000 USD to 2 640 000 USD). The median cost of a complete adjuvant treatment was 158 000 USD per patient.

https://www.esmo.org/oncology-news/anticancer-drugs-in-the-adjuvant-setting-have-considerable-costs-per-event-averted-raising-questions-of-sustainability


   
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