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Answer on Digital Papillary Adenocarcinoma

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Answering Patrick's question on Digital Papillary Adenocarcinoma at

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Dear Patrick,

Thank you for your comment and question. I am sorry you have to go through this and hope that soon you will start to be better and better.

Regarding conventional treatment I checked Aggressive Digital Papillary Adenocarcinoma and as you probably know, this is a short summary:
- Surgery: if possible this is the best counventional treatment approach
- Radio and chemo: according to this paper (<a href="" rel="nofollow">Ref</a>.)
o all of the cases reported in literature lead to little or no improvement with no obvious benefit
o there is no agreed standardization of the use of adjunctive chemotherapy or regimens, but agents used before and reported in the literature include cisplatin, gemcitabine, 5-FU, mitomycin, adriamycin, thiotepa, fluoxymesterone, carboplatin, paclitaxel, docetaxel, and VP-16

Therefore, based on the above, if the doctor is going to try Doxorubicin, I would do the best to use approaches that could support Doxorubicin and try to increase the chance for effectiveness. Next to that I would add other treatment options that may add extra chances. I would also try Fenbendazole indeed.

While I do not know many details regarding the tumor size, exact location, history, etc, here are some ideas that may be relevant:
1. ADPA shows tumor overexpression of FGFR2 indicating that targeting the fibroblast growth factor (FGF)/FGF receptor axis might be a promising treatment for ADPA and probably for the overall group of sweat gland carcinomas.
Example of drugs and supplements that interfere with FGF/ FGFR are listed in the Tble 1 of the following paper (or
Of these, some that I consider most relevant are Tranilast, Celecoxib, Thalidomide, Curcumin, EGCG, Resveratrol. All have been shown to inhibit FGF. To make sure I address well FGF, I would use two drugs and two supplements, e.g. Celecoxib + Tranilast or Thalidomide and Curcumin+EGCG
2. If the tumor is at the surface, I would also consider making solutions for topical administration such as that described here
Whenever I would use a new substance, I would only apply on a very small portion of the skin to test the reaction. Other substances can also be mixed with e.g. 70% DMSO for topical applications.
3. There are multiple intravenous treatments discussed on this website that may help, such as Salinomycin, Diflunisal, 3BP, Taurolidine, Curcumin, 2DG
All can be accessible for anyone who really wants them and who has a medical trained person that is willing to help with administering them. However, they should be treated with care as they are experimental therapies, yet with high chance of anti cancer activity.
Of these intravenous therapies, one of the easiest to implement that may help increase the effectiveness of chemo is 2DG 2DG for intravenous admin is available at German pharmacies and if you have a doctor who is willing to help I can connect him with an academic team from US that will help him for free with relevant info for implementation of this treatment. Usually it’s given after chemo for 2 days via an infusion pump (in the same way as 5-FU chemo is given to patients).
4. Fenbendazole and any other drug and supplement that is expected to reduce tumor activity should be stop about 3 days before chemo day, and start again during the chemo day
5. Fasting before chemo may help reduce the side effects of Doxo and may help increase it’s effectiveness
6. Combining glucose absorption inhibitors such as those discussed here with mitochondria inhibitors such as those discussed here may help. Of these, one combination could be Canagliflozin with Metformin
When using more drugs, you can always check the interaction between the drugs here besides discussing that with doctors
7. You can also contact Care Oncology Clinic and consider starting up this drug cocktail including Metformin, Doxycycline, Statin and Mebendazole
8. Doxorubicin that you are using is a weak basis, which means that there is a high chance for Doxo to be deactivated by the acidity around the tumor before getting into the tumor as discussed here
In order to minimize this chance, I would use strategies that would be alkalize the body. Some obvious ways to do that are using Sodium Bicarbonate, or Basentabs prior to chemo. In addition, using proton pump inhibitors such as Omeprazole (this is easy to get) may help. I discussed this in more details here Chloroquine (an anti-malaria drug) combined with Omeprazole may further help increase effectiveness of chemos such as Doxorubicin I wrote some more words about Chloroquine here

I hope these ideas help.

Kind regards,