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"Searching for novel connections in cancer metabolism"


johan
(@j)
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https://scienceblog.cancerresearchuk.org/2020/06/19/searching-for-novel-connections-in-cancer-metabolism/

"“I think this is one of the first few studies, or maybe even the first, that shows a dietary fat restriction plays a major role in therapy response.” Dr George Poulogiannis


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Yudaitheska
(@yudaitheska)
Joined: 3 years ago
Posts: 32
 

This relates to the omega 3- omega 6 ratio I believe. The predominance of omega 6 in diet leads to more production of arachidonic acid


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johan
(@j)
Joined: 3 years ago
Posts: 638
Topic starter  

@yudaitheska

 

yes, eliminating as much omega 6 from the diet


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Yudaitheska
(@yudaitheska)
Joined: 3 years ago
Posts: 32
 

@johan

I found this article very interesting

https://pubmed.ncbi.nlm.nih.gov/30686744/

Polyunsaturated Fatty Acid
Desaturation Is a Mechanism
for Glycolytic NAD+ Recycling

The reactions catalyzed by the delta-5 and delta-6
desaturases (D5D/D6D), key enzymes responsible
for highly unsaturated fatty acid (HUFA) synthesis,
regenerate NAD+ from NADH. Here, we show that
D5D/D6D provide a mechanism for glycolytic NAD+
recycling that permits ongoing glycolysis and cell
viability when the cytosolic NAD+
/NADH ratio is
reduced, analogous to lactate fermentation. Although
lesser in magnitude than lactate production, this de-
saturase-mediated NAD+ recycling is acutely adap-
tive when aerobic respiration is impaired in vivo.
Notably, inhibition of either HUFA synthesis or lactate
fermentation increases the other, underscoring their
interdependence. Consistent with this, a type 2
diabetes risk haplotype in SLC16A11 that reduces
pyruvate transport (thus limiting lactate production)
increases D5D/D6D activity in vitro and in humans,
demonstrating a chronic effect of desaturase-medi-
ated NAD+ recycling. These findings highlight key
biologic roles for D5D/D6D activity independent of
their HUFA end products and expand the current
paradigm of glycolytic NAD+ regeneration


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