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Stage 4 CRC/Metastatic to the Liver

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(@j)
Joined: 6 years ago
Posts: 2135
 
Posted by: @zed85

She takes the E and Curcumin as well. 

@zed85 Considering curcumin is fat-soluble, and the probable Curcumin-ALA antagonism and Curcumin-DHA synergy, I'd take CURC with a DHA supplement.


   
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(@j)
Joined: 6 years ago
Posts: 2135
 

A note on Vitamin E.

I believe, not sure though, that the rationale for the use of Vitamin E in the fenben protocol comes from this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/

It's important to note that the supplemented vitamins included B, D, K, E, and A. 

Now, considering that in quite a few studies vitamin E had a cancer-promoting effect, I'd be cautious with this particular vitamin.

Vitamin E promotes breast cancer cell proliferation by reducing ROS production and p53 expression

https://pubmed.ncbi.nlm.nih.gov/27383327/

Antioxidants Accelerate Lung Cancer Progression in Mice

https://stm.sciencemag.org/content/6/221/221ra15/tab-figures-data

Vitamin E Supplements May Raise Lung Cancer Risk

https://www.medicinenet.com/script/main/art.asp?articlekey=87525

https://www.medscape.com/viewarticle/915121

https://www.medscape.com/viewarticle/915121

There are many types of vitamin E, and I know many studies show anti-cancer potential but just wanted you to be aware of the above. 

 


   
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(@j)
Joined: 6 years ago
Posts: 2135
 

Apoptosis mediated chemosensitization of tumor cells to 5-fluorouracil on supplementation of fish oil in experimental colon carcinoma

https://pubmed.ncbi.nlm.nih.gov/28349837/


   
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(@j)
Joined: 6 years ago
Posts: 2135
 

Butyrate Suppresses Glucose Metabolism of Colorectal Cancer Cells via GPR109a-AKT Signaling Pathway and Enhances Chemotherapy

https://www.frontiersin.org/articles/10.3389/fmolb.2021.634874/full

"It was found that butyrate significantly suppressed the glucose metabolism of cancerous colonocytes by reducing the abundance of membrane GLUT1 and cytoplasmic G6PD, which was mediated by the GPR109a-AKT signaling pathway. Moreover, butyrate markedly promoted the chemotherapeutical efficacy of 5-fluorouracil (5-FU) on colorectal cancer cell, by further inhibiting the DNA synthesis efficiency with 5-FU. Our results provide useful information of the suppressing effects of butyrate on the glucose metabolism of colorectal cancer cells as well as the underlying molecular mechanism, which would promote the development of butyrate as a therapeutical or adjuvant anti-cancer drug."


   
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(@abidingtoday)
Joined: 2 years ago
Posts: 129
 

@j do you feel like tocotrienols, apart from ROS (chemo, radiation, high-dose IVC), are advisable?


   
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(@j)
Joined: 6 years ago
Posts: 2135
 
Posted by: @abidingtoday

@j do you feel like tocotrienols, apart from ROS (chemo, radiation, high-dose IVC), are advisable?

To date, there is too much conflicting data on VIT E for me to consider in the treatment of cancer. There are much better and safer options IMO. 


   
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(@barnettann)
Joined: 2 years ago
Posts: 1
 

@j do you think niclosamide is a better option than fenben for colon cancer with mets to the liver? Asking because you mentioned you are not a fan of Tippens 


   
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(@j)
Joined: 6 years ago
Posts: 2135
 
Posted by: @barnettann

@j do you think niclosamide is a better option than fenben for colon cancer with mets to the liver? Asking because you mentioned you are not a fan of Tippens 

I don't know.


   
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