Posted by: @odetteeksteen

1. Where does colorectal cancer 'usually' metastasize to - I have read somewhere liver and kidneys?  I want to provide special 'protection' for these organs. Any advice regarding supplements for these areas?

 

 

Hi Odette,

the liver is a likely place for metastasis. 

Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882699/

IP6GOLD (available on iherb.com) is a great supplement.

EGCg is also useful in colorectal cancer, and combined with curcumin could be even better:

Combination curcumin and (−)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway

https://www.nature.com/articles/oncsis201784

Best,

Johan

Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin—Two Main Metabolites of Curcuma longa—in Cancer Cells

https://www.frontiersin.org/articles/10.3389/fphar.2017.00038/full

The curcumin/AA combination was assessed by isobologram analysis using the Loewe additivity drug interaction model. The drug combination showed additive cytotoxicity toward CCRF-CEM and CEM/ADR5000 leukemia cell lines and HCT116p53^+/+ and HCT116p53^−/− colon cancer cell line, while the glioblastoma cell lines U87MG and U87MG.ΔEGFR showed additive to supra-additive cytotoxicity. Gene expression profiles predicting sensitivity and resistance of tumor cells to induction by curcumin and AA were determined by microarray-based mRNA expressions, COMPARE, and hierarchical cluster analyses. Numerous genes involved in transcription (TFAM, TCERG1, RGS13, C11orf31), apoptosis-regulation (CRADD, CDK7, CDK19, CD81, TOM1) signal transduction (NR1D2, HMGN1, ABCA1, DE4ND4B, TRIM27) DNA repair (TOPBP1, RPA2), mRNA metabolism (RBBP4, HNRNPR, SRSF4, NR2F2, PDK1, TGM2), and transporter genes (ABCA1) correlated with cellular responsiveness to curcumin and ascorbic acid. In conclusion, this study shows the effect of the curcumin/AA combination and identifies several candidate genes that may regulate the response of varied cancer cells to curcumin and AA.

Maitake + VitC (liver): the mechanism of anticancer activity in the SMMC-7721 hepatocarcinoma cells involved induction of apoptosis.

Synergistic Apoptotic Effect of D-Fraction From Grifola frondosa and Vitamin C on Hepatocellular Carcinoma SMMC-7721 Cells 

https://journals.sagepub.com/doi/full/10.1177/1534735416644674

Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner

https://www.sciencedirect.com/science/article/pii/S1347861317301895

@odetteeksteen

I know colorectal cancer patient and a j-pounch who used Cimetidine, Artemisinin, Quercetin, Mebendazole and a few other food supplements after surgery and +5 years cancer free.

I would never try to get read of the j-pounch. Some patients tried to remove that and cancer came back, due t the inflammation from surgery.

Kind regards,
Daniel

Posted by: @odetteeksteen

Hi!

I am looking for info from people that share my diagnosis of colorectal cancer.  I had chemo, radiation, surgery to remove the tumour, a radical hysterectomy and a J-pouch. I am NED for 1 year now and worry that my lifestyle my result in a recurrence.   I take a pro-biotic, milk thistle and turmeric daily. My questions:

1. Where does colorectal cancer 'usually' metastasize to - I have read somewhere liver and kidneys?  I want to provide special 'protection' for these organs. Any advice regarding supplements for these areas?

2. Is there any post colon cancer protocol that someone has used successfully for a time that they are willing to share with me?

3. I have incontinence due to damage to my nerves from surgery and radiation - anyone have any info on ways/surgery to deal with this?

4. I am looking for a detox to try and alleviate some of my brain fog, I was on cisplatin - anyone know of a good/gentle way to detox without recirculating all the heavy metals within my body.

5. Can neuropathy in the feet be lessened?

 

Thanks for allowing me to share my worries.

 

Hi Daniel and everybody!

My mother is 13 months after colon cancer surgery. Though she is dealing with some flu at the moment, it´s luckily the biggest health problem we have had so far (apart from occasional diarrhea and some continuous tongue blisters even 1 year after limited chemo - 3 rounds of oxaliplatin and 5FU at half doses).

Her blood tests from previous week were perfect (guess CRP is not 0 now with the flu) and CT a X-rays all clear.

CEA from last 6 months: 1.5, 2.7, 2.0, 1.9

Current protocol:

Metformin: 3*500mg

Atorvastatin: 2*10mg

Aspirin: 100mg

Diclofenac: 2*25mg

Milk Thistle: 3*400mg (+Curcumin 300mg, Piperin 30mg as boosters in the capsules)

Alpha Lipoic Acid: 2*600mg

HCA: 2*550mg

Tocopherol: 3*270mg

CoQ10: 3*125mg

Reishi: 500mg

Cordyceps or Coriolus: 3*1000mg

Melatonin: 20mg

Vitamin C: 2000-3000mg

Vitamin D3: 5000IU

Selenium, Zinc, Magnesium, Vit. B Complex, Vit. A, Probiotics

Saponins: 3*1000mg

We also occasionally pulse Quercetin - 3*475mg, EGCG - 3*400mg, L-Carnitin - 2*500mg and Dipyridamole - 3*75mg

She also drinks green tea, chamomile tea, dandelion root tea and avoids sugar, red meat and processed food.

What do you think? Is it OK? Should we add something? Is it too much?

Hi everybody, 

I'm also trying to design an anti recurrence protocol and it's not easy ; I have concerns about the use of anti oxydants ; While preclinical datas mostly supports the use of AO's, several clinical trials indicate that it can lower survival ; Most of them are focused on tocopherols/beta-carotene and some(but not all of them) put the patient on suplement at the begining of chemo/radiation which could explain bad outcome.

I see Zdenek that you have several AO's in your protocol ; So do I ; 

Is too much AO's could harm in maintenance mode ? I understand now that in the cancer world, its never black or white ; a grey answer is good enough ; ) 

Thanks to the cancer genius we have in this forum ; ) 

@julienach

Aging and cancer are the result of intracellular damage which is generated by energy production often through ROS, so everything that helps mitochodria to work effectively a minimise ROS should promote health and longevity.

If you are not doing chemo, I don´t see a point in damaging the system further with a pro-ROS strategy, quite the opposite.

Zdenek, 

I totally agree with the logic ; However, some clinical trial point in a other direction :

https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.22042

https://www.frontiersin.org/articles/10.3389/fphys.2014.00245/full

This study suggest that VitE in particular could have pro oxydant effect :

https://www.sciencedirect.com/science/article/abs/pii/S0002914908002130

There is a huge amount of conflicting litterature on antioxydant and cancer. 

@julienach

I don´t use vit. E or beta caroten, only the mix of alpha, delta and gamma tocopherol. The evidence for any negative effects of tocopherols is weak at best.

I´m always amazed that people stress over supposed negative effects of vitamins, statins, aspirin, metformin or NSAIDs and ignore all the positives but let themselves be subjected to highly toxic chemotherapies. F.e. 5FU kills around 1000 people in the US every year through DPD deficiency and other side effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899293/

@johan

Thank you for the great information! I appreciate your time to reply.

@zdeneksipek

Thank you for the information - that is quite a hefty regime that your mom follows, I am impressed! I can see a lot of research and thought has gone into this - thanking for sharing.