An idea for using D...
 

An idea for using DCA for colon cancer  

  RSS

Mahdi
(@mahdi)
New Member
Joined: 2 years ago
Posts: 3
05/09/2018 6:02 am  

I have an idea using DCA in the combination of Atovaquone (both orally) for removing opposite effect of hypoxia. Any experience or idea on effectiveness on colon or dose correlation between two agents are welcome


Quote
Daniel
(@daniel)
New Member Admin
Joined: 4 years ago
Posts: 302
05/09/2018 11:20 am  

Hi Mahdi,

Why you think this combination would target hypoxia specifically, other than their general anti cancer effects.

Because Atovaquone is a mitochondria inhibitor while DCA "redirects" pyruvate to mito, the combo of the two should be a good idea as it should act in the same way as DCA & Metformin, shown in the lab to have an enhanced capability for killing cancer cells.

I wrote a post on DCA where I discussed dose  https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/

And here is a good article on Atovaquone  https://www.ncbi.nlm.nih.gov/pubmed/27136895

However, I have no info on correlating the two in terms of dose. I do not expect you can find such info as it is very specific and may depend on drug dynamics in each person. The best that can be done is to take a safe dose of each in combo. 

Finally, thanks for your question as it brought to my attention Atovaquone as a mitochondria inhibitor.

Kind regards,
Daniel

 

This post was modified 10 months ago by Daniel

ReplyQuote
Mahdi
(@mahdi)
New Member
Joined: 2 years ago
Posts: 3
05/09/2018 12:14 pm  

Hypoxia (oral):

https://www.nature.com/articles/ncomms12308

What makes does correlation, crucial:

DCA treatment also induced significantly increased growth of SW480 tumor ...

https://www.sciencedirect.com/science/article/pii/S030438351000251X

Thanks for info


ReplyQuote
Mahdi
(@mahdi)
New Member
Joined: 2 years ago
Posts: 3
05/09/2018 12:27 pm  

using DCA alone make colon cancer worst


ReplyQuote
Share: