Dear Carl,

I wrote a very long post to you and when I was close to end it was gone … next time will write in word … so here I will write it again, a little shorter:

I am sorry to hear that you may have to dale with a recurrence. Next to all the ideas shared in my posts that may be relevant, here are some specific ideas for cervical cancer (since I understand this is the primary type):

-          Acetozolamide may be relevant. This is because CA IX is known to be overexpressed in cervical cancer https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-12 http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2007.00396.x/pdf

-          Bisphosphonate https://www.ncbi.nlm.nih.gov/pubmed/15343380   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862314/

-          Diflunisal may also be relevant specifically because CA IX may be overxepressed. CA IX would be a sign for higher acidity around the tumors and Diflunisal works only in acidic environment. Update on pilot study on antitumor efficacy of intravenously applied synergistic combinations of diflunisal, PAS, and aspirin in patients with advanced solid tumors. http://www.medicdebate.org/node/978

-          Celcoxib as Cox2 inhibitor – Cox2 seems to be very relevant for cervical cancers https://www.ncbi.nlm.nih.gov/pubmed/11234900 http://www.nature.com/bjc/journal/v87/n10/full/6600578a.html

-          Cafeic acid http://www.sciencedirect.com/science/article/pii/S1028455910600927   http://www.ejcancer.com/article/S0959-8049(16)31990-6/abstract   https://www.researchgate.net/publication/282595067_Anticancer_Effect_of_Caffeic_Acid_on_Human_Cervical_Cancer_Cells Cafeic Acid can be fount in high amounts in Propolis from Manuka Bio100 like this one http://www.return2health.net/brands/manuka-health/propolis-capsules-60/ If you want to buy best is to contact Manuka directly and it may be much cheaper. If you want to do that just let me know and will give you my contact person from whom I ordered during the past years.

-          Interferon alpha may help https://sciforum.net/conference/ecms-1/paper/3020/download/pdf there is a clinic in US claimining very good results http://www.neoplas.org/id16.html and they essentially are using Interferon alpha with Lovastatin according to this patent https://www.google.com/patents/US20030232033?dq=lovastatin+interferon&hl=en&sa=X&ei=ZgM7VMHfN66V7Aayl4GACw&ved=0CB0Q6AEwAA

-          Doxycicline https://www.ncbi.nlm.nih.gov/pubmed/26913972 https://www.ncbi.nlm.nih.gov/pubmed/26111245  I now realize you are already using this one.

-          Tigecycline https://www.ncbi.nlm.nih.gov/pubmed/26427870 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133451/

-          Virtually all cases of cervical cancer are caused by HPV. In this context, the combo of lopinavir and ritonavir as used here may be relevant http://fusion.kinja.com/we-may-soon-have-a-cure-for-the-worlds-most-common-std-1793856160   http://news.bbc.co.uk/2/hi/health/5282206.stm

These are just some ideas but maybe you already went through these?

Kind regards,

Daniel

Dear Carl,

Since you mentioned this is possibly a recurrence in the balder of a tumor of cervical origin, I moved this topic from Bladder to Cervical.

Kind regards,

Daniel

Hi Carl,

How sure are you that this is a cancer recurrence and not a more benign cause of hematuria?

I've had several bouts with hematuria - due to kidney cancer once but also due to taking Aspirin and Diclofenac while having a stent in place. It's possible that some other injury occurred in the GU tract and has been unable to effectively repair due to the platelet inhibition of Aspirin.

I've also had a family friend with recurrent hematuria with blood clot discharge for months, which ended up being a kidney stone. 

Hi and thank you so much for your reply. You are right, I am not sure at all yet. I am hoping the hematuria is due to radiation cystitis. She has also been on been on Aspirin and Dipyridamole (which I  know temporarly have removed). I suppose I am just trying to be proactive. There were some concerns of metastasis (that wasn't confirmed)  in the bladder at the time of the diagnosis, which is making me worried.

@Daniel, your input is invaluable. Thank you so much. I will have a more detailed read through later today. Thanks again!

Fortunately, the hematuria was due to radiation cystitis and not a recurrence. Thanks again for your support and suggestions. I will do some changes to our protocol and would really appreciate feedback. The target is squamous cell carcinoma of the cervix. Unfortunately, I have no information on mutations. The objective is to maintain the current NED, so I would like to understand what dosage is sufficient to prevent recurrence, opposed to treat an active disease. I would also appreciate any feedback on our current protocol (see attached)

I may add Diflunsial to address CA IX, but given the tricky methods of administration, I think I will go for Acetazolamide, which is also easier for me to come by. However, it seems to be contraindicated for co-administration with salicylates like Aspirin and it may increase the risk for lactic acidosis when taken with Metformin. Any thoughts on long-term use and the usefulness of a low dose administration?

Very interesting info on Bisphosphonate! I knew about its usefulness for breast cancer patients but very good to know it’s applicable for cervical cancer. What would be a sufficient dose?

Cox-2 seems indeed to often be over expressed and that’s why (low-dose) aspirin is part of our protocol. Also because of its anti-platelet properties. But since Aspirin might aggravate the cystitis there are perhaps better options. What about Celebrex + Dipyridamole), instead of Aspirin?

Propolis (green from Brazil) used to be part of our protocol, but Manuka seems to be a better option so I have added that. Unfortunately the manufacturer you recomended seems to have discontinued the Manuka 100. Only the 30 concentration is available.

Interferon alpha: Very very nice find. Good to have as a backup.Thanks!

Doxycyline like Tigecycline, also seems to inhitib Wnt/β-catenin. Tigecycline seems to be harder on the gut as well. Any advantages of Tigecycline over Docycycline?

Using antivirals is a good idea. We used high dose AHCC for two years which hopefully addressed the HPV infection https://www.sciencedaily.com/releases/2014/10/141028122424.htm

Thank you!