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Triple Negative Breast Cancer (TNBC)

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(@j)
Joined: 6 years ago
Posts: 2136
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Quite a few options here other than the drug used in the study: Azithromycin, Artemisinin and derivatives, mefloquine, Cannabidiol, Methylene blue, grapefruit, etc


   
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(@j)
Joined: 6 years ago
Posts: 2136
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No coffee with Taxol: Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation https://www.sciencedirect.com/science/article/pii/S075333222030634X


   
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(@j)
Joined: 6 years ago
Posts: 2136
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Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics

https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2505-9

" Conclusion Hibiscus extract is effective on breast cancer, most notably on generally resistant triple-negative breast cancer, while being selective for normal healthy cells. Hibiscus extract could supplement chemotherapeutic regimens as an adjuvant and lead to a more efficacious treatment approach to reduce chemotherapy dosages and related toxicity."


   
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(@j)
Joined: 6 years ago
Posts: 2136
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Naloxone Counteracts the Promoting Tumor Growth Effects Induced by Morphine in an Animal Model of Triple-negative Breast Cancer


   
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(@j)
Joined: 6 years ago
Posts: 2136
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I've attached an updated pathways diagram 


   
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(@j)
Joined: 6 years ago
Posts: 2136
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Nifuroxazide boosts the anticancer efficacy of palbociclib-induced senescence by dual inhibition of STAT3 and CDK2 in triple-negative breast cancer

https://www.nature.com/articles/s41420-023-01658-w

What's interesting is that Nifuroxazide, an antibiotic, can reduce ammonia.

 

 


   
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(@j)
Joined: 6 years ago
Posts: 2136
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Nifuroxazide attenuates experimentally-induced hepatic encephalopathy and the associated hyperammonemia and cJNK/caspase-8/TRAIL activation in rats

 


   
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(@j)
Joined: 6 years ago
Posts: 2136
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I don't think I've posted this before:

β-Catenin Is Required for the Tumorigenic Behavior of Triple-Negative Breast Cancer Cells

(can't post a link b/c of antispam settings)

Also, β-Catenin potentiates transcription of HIF1α's tumor-promoting target genes.

Here are a few options that may inhibit β-Catenin:

Cardamonin
Baicalin
Arctigenin (burdock)
Panax ginseng
Evodiamine
EGCG
Ellagic acid
Ursolic acid
Celecoxib
Shikonin


   
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(@rosed)
Joined: 2 years ago
Posts: 56
 

@j THanks Johan

 


   
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(@j)
Joined: 6 years ago
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Noteworthy, TOP2A acts as a co-activator of beta-catenin. Ellagic acid, hydroxyquinone (bearberry leaf extract) inhibits TOP2A.


   
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