A Positive Feedback Loop Between TGFβ and Androgen Receptor Supports Triple-negative Breast Cancer Anoikis Resistance
Honokiol and Berberine suppress androgen Receptor signaling.
I've updated the TNBC synergy diagram. A reminder that the synergistic combinations aren't all specific to TNBC but cancer in general. However, the substances listed have been the subject of studies showing their anticancer potential specifically in TNBC.
Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells
Epigenetic restoration and activation of ERβ: an inspiring approach for treatment of triple-negative breast cancer
https://link.springer.com/article/10.1007/s12032-022-01765-1
Antiproliferative Effects of Various Furanoacridones Isolated from Ruta graveolens on Human Breast Cancer Cell Lines
Abstract
Background/Aim: Thanks to its biologically active constituents, Ruta graveolens L. (Rutaceae) is a widely used medicinal plant. In our study, six furanoacridone alkaloids isolated from Ruta graveolens were investigated for their antiproliferative and pro-apoptotic effects on human breast cancer cell lines (MCF-7, MDA-MB-361, MDA-MB-231 and T47D). Materials and Methods: The cell lines were pretreated with alkaloid components (rutacridone, isogravacridone chlorine (IGC), gravacridonediol monomethyl ether, gravacridonediol, gravacridonetriol, a 1:1 mixture of gravacridonetriol and - diol monoglucosides) and their antiproliferative effects were determined by the MTT assay. Results: IGC had the most marked effect on cell proliferation of MDA-MB-231 (half maximal inhibitory concentration (IC50)=2.27 μM). Cell-cycle analysis was applied to quantify the effect of IGC on subpopulations of MDA-MB-231 and MCF-7 cells. It caused a cell-cycle disturbance by decreasing the G2/M and G0/G1 and increasing the S phase and the appearance of the subdiploid (sub-G1) population. Hoechst 33258-propidium iodide staining was used to evaluate the morphological changes in IGC-pretreated MDA-MB-231 and MCF-7 cells, revealing the appearance of apoptotic features. IGC was found to cause a modest activation of caspase-3 and -9, but not caspase-8, indicating the activation of an intrinsic apoptotic pathway in MDA-MB-231 cells. Conclusions: These in vitro findings indicate that furanoacridones are suitable candidates for anticancer drug development.
Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37375496
Exploiting signaling signatures in triple-negative breast cancer to identify targetable vulnerabilities
pardon my obsession with ammonia but here's yet another link:
Consuming foods high in fat promotes Gram-negative bacteria in the gut {ref}
Gram-negative bacteria produce more ammonia {ref}
Gram-negative bacteria promote cancer {ref}
which in my view explains why antibiotics can be useful in cancer treatment, on the condition that the antibiotics reduce the bacteria that produce the most ammonia. On top of other strategies to reduce ammonia.
chronotherapy: "“We found important—up to five-fold—differences in toxicities and near doubling in efficacy of the same chemotherapy regimen, when it was given at chronomodulated infusion compared to a constant rate,”
https://www.science.org/content/article/breast-cancer-cells-are-more-aggressive-during-sleep
Next-generation sequencing reveals altered gene expression and enriched pathways in triple-negative breast cancer cells treated with oleuropein and oleocanthal
Anticancer Effects of Fucoxanthin through Cell Cycle Arrest, Apoptosis Induction, and Angiogenesis Inhibition in Triple-Negative Breast Cancer Cells
Updated Austrian treatment algorithm for metastatic triple-negative breast cancer
https://link.springer.com/article/10.1007/s00508-023-02254-9
Data from the recently published phase III ASCENT trial suggest that the treatment with sacituzumab govitecan significantly improves outcomes for this difficult to treat patient population. With an unprecedented PFS benefit of 4.9 months and a benefit in median OS of 5.4 months, with a hazard ratio for death of 0.48 compared to single-agent chemotherapy, this first in class Trop‑2 ADC has the clear potential to set a new standard for patients with mTNBC.
Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo
https://www.oncotarget.com/article/11615/text/
Note that homocysteine can be converted to methionine
Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
https://link.springer.com/article/10.1007/s00394-023-03087-y
@j Hey Johan, hope you are keeping well! Thanks for all the posts!!!! What do you think of this article......
@rosed Hi Rosaleen, thanks, feeling good! What a great find... acetate! Phenyl acetate is an ammonia scavenger and found in fruits like apples and grapes, fruits that have been used in Johanna Brandt's The Grape Cure, and Max Gerson used apples in his cancer therapy/diet. No coincidence in my opinion 🙂
@j Going down the grape rabbit hole and saw this.... interesting.... gonna have a look to see what might be a reputable source of this extract....
interesting article......
I am wondering if this new Israeli product Vinia contains grape skin extract? Very hard to make out what they say it contains.
@rosed they don't make it easy to find out what's in it!
Mighty Muscadine® Grape Supplement contains the skin and seeds.
Btw, I'd always buy organic fruit, grapes in particular. Fruit and food in general aren't the same as when Brandt and Gerson experimented with it to treat cancer.
Other good sources of phenyl acetate are grapefruit, guava fruit, melon, papaya, raspberry, strawberry, cherimoya, passion fruit, Swiss cheese, Zea mays, and black tea.
These scientists were excited about the therapeutic potential of grapes:
https://www.youtube.com/watch?v=oHqlXdp5JYs
As often there's not so much follow-up when it comes to this type of discovery.
Plant-derived exosome-like nanoparticles and their therapeutic activities
https://www.sciencedirect.com/science/article/pii/S1818087621000556
Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide
https://www.sciencedirect.com/science/article/abs/pii/S0278691518302941
Baicalein and sulforaphane may work synergistically with myricetin: https://synergiesforcancertreatments.blogspot.com
Chronobiological assessment of triple-negative breast cancer.
Conclusions: The study results have showed significant biochemical differences between ER/PR+/ Her2/neu- and TNBC- patients. Reduction of circadian secretion of Melatonin, as a major biochemical marker, directly correlates with the degree of cancer aggression, as it is seen fom the study. Furthermore, in patients whose Melatonin concentration was critically low, ductal (CK5/6+ and/or EGFR+) and metaplastic (epidermal: CK5/6+, EGFR+, Ck14+, p63+) forms were histochemically detected, which are extremely aggressive subtypes of TNBC. Regarding Cortisol levels in patients with critically Melatonin level, the Cortisol concentration was at critically low margin as well, that is considered to be the additional chronobiological marker for the aggressive course and rapid progression of cancer.
(The link didn't pass the forum's antispam settings)
Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells (epinephrine is adrenaline)
jci.org/articles/view/121685
Low salt intake increases adrenaline (epinephrine)
Chronobiological assessment of triple-negative breast cancer.
Conclusions: The study results have showed significant biochemical differences between ER/PR+/ Her2/neu- and TNBC- patients. Reduction of circadian secretion of Melatonin, as a major biochemical marker, directly correlates with the degree of cancer aggression, as it is seen fom the study. Furthermore, in patients whose Melatonin concentration was critically low, ductal (CK5/6+ and/or EGFR+) and metaplastic (epidermal: CK5/6+, EGFR+, Ck14+, p63+) forms were histochemically detected, which are extremely aggressive subtypes of TNBC. Regarding Cortisol levels in patients with critically Melatonin level, the Cortisol concentration was at critically low margin as well, that is considered to be the additional chronobiological marker for the aggressive course and rapid progression of cancer.
(The link didn't pass the forum's antispam settings)
Both melatonin and cortisol are critically low, but I think the low cortisol occurs because it's used by cancer for growth and metastasis whereas melatonin is being depleted in response to cancer.
Chronobiological assessment of triple-negative breast cancer.
Conclusions: The study results have showed significant biochemical differences between ER/PR+/ Her2/neu- and TNBC- patients. Reduction of circadian secretion of Melatonin, as a major biochemical marker, directly correlates with the degree of cancer aggression, as it is seen fom the study. Furthermore, in patients whose Melatonin concentration was critically low, ductal (CK5/6+ and/or EGFR+) and metaplastic (epidermal: CK5/6+, EGFR+, Ck14+, p63+) forms were histochemically detected, which are extremely aggressive subtypes of TNBC. Regarding Cortisol levels in patients with critically Melatonin level, the Cortisol concentration was at critically low margin as well, that is considered to be the additional chronobiological marker for the aggressive course and rapid progression of cancer.
(The link didn't pass the forum's antispam settings)
Both melatonin and cortisol are critically low, but I think the low cortisol occurs because it's used by cancer for growth and metastasis whereas melatonin is being depleted in response to cancer.
"blood or bone marrow cancer - acute myeloid leukemia (AML) - cells evade the anti-cancer activity of the human immune system by employing the human hormone cortisol. They do this by using cortisol to force the release of a protein, latrophilin 1. This, in turn, causes the secretion of another protein, galectin-9, which suppresses the body's natural anti-cancer immune mechanism."
deccanchronicle.com/lifestyle/health-and-wellbeing/150818/stress-hormone-key-to-prevent-leukemia-study.html
