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Triple Negative Breast Cancer (TNBC)

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(@j)
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I've posted some of these studies before but ginger is such a wonderful anticancer substance and so easy to integrate into any diet:

[10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDAMB- 231 Breast Tumor Cells
https://pubmed.ncbi.nlm.nih.gov/30370858/

[6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells
https://www.sciencedirect.com/science/article/abs/pii/S0955286307001337

10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and [p38.sup.MAPK] activity
https://pubmed.ncbi.nlm.nih.gov/26554741/

Phytochemicals potently inhibit migration of metastatic breast cancer cells
https://academic.oup.com/ib/article/7/7/792/5199042

Anthocyanin and Gingerol Extracts Exhibit a Synergistic Effect to Inhibit the Proliferation of Caco-2, Hep G2, and HT-29 Cells in Vitro
"Strong synergism levels at high growth inhibitory effects suggest that the anthocyanin–gingerol combination has high potency for the inhibition of cancer cell growth."
https://pubs.acs.org/doi/abs/10.1021/acsfoodscitech.1c00029


   
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(@j)
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updated TNBC pathway diagram


   
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(@j)
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Effect of telmisartan on triple-negative breast cancer (TNBC) and lung cancer tumor progression and intratumoral distribution of nanoparticles
https://aacrjournals.org/cancerres/article/73/8_Supplement/2139/587859/Abstract-2139-Effect-of-telmisartan-on-triple

"Conclusion: Telmisartan showed significant anticancer effects in Lung cancer and TNBC. Telmisartan could be an ideal candidate for combination therapy to improve the NPs intratumoral distribution and anticancer effects in various cancer types."


   
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(@j)
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Artificial diets with selective restriction of amino acids and very low levels of lipids induce anticancer activity in mice with metastatic triple-negative breast cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000978/

 


   
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(@j)
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so more evidence a ketogenic diet is a bad choice for cancer patients and for TNBC in particular. 


   
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(@j)
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New apoptotic anti-triple-negative breast cancer theobromine derivative inhibiting EGFRWT and EGFRT790M: in silico and in vitro evaluation

https://pubmed.ncbi.nlm.nih.gov/37162644/


   
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(@j)
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pathway diagram updated


   
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(@j)
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Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins

https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-021-01488-7


   
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(@j)
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The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332637/

50mg/kg HED approx 300mg

 


   
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(@rosed)
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@j Thank you so much for this.  I have been MIA for a bit.  The biopsy they insisted on doing before surgery to remove the visible lump before surgery caused two new tumors. It is like a connect-the-dots nightmare.  Two tumors seeded by biopsy that I didn't need because the lump was visible, and it was in the exact same spot as my initial tumor.  I am so angry.  They insisted on biopsy or they would not give me appointment with surgeon. ANyway..... I am so grateful for this post on the ketogenic diet and TNBC.  Although I am now Her2 positive, I still have some TNBC. So...... my integrative oncologist who I speak to every now and again suggested Ketogenic because my IGF is higher than normal range.  However, in my gut, I always felt that it was not wise for TNBC because of the fats.  Uggh. ANyway.... good to be back.  I am thinking of getting these two tumors cryoablated.  

 


   
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(@j)
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Posted by: @rosed

@j Thank you so much for this.  I have been MIA for a bit.  The biopsy they insisted on doing before surgery to remove the visible lump before surgery caused two new tumors. It is like a connect-the-dots nightmare.  Two tumors seeded by biopsy that I didn't need because the lump was visible, and it was in the exact same spot as my initial tumor.  I am so angry.  They insisted on biopsy or they would not give me appointment with surgeon. ANyway..... I am so grateful for this post on the ketogenic diet and TNBC.  Although I am now Her2 positive, I still have some TNBC. So...... my integrative oncologist who I speak to every now and again suggested Ketogenic because my IGF is higher than normal range.  However, in my gut, I always felt that it was not wise for TNBC because of the fats.  Uggh. ANyway.... good to be back.  I am thinking of getting these two tumors cryoablated.  

 

Hi Rosaleen, sorry to hear this, it's infuriating. I've attached a graph from Don who used to post his progress on this forum in great detail, you can see how his cancer marker increased on the keto diet, and reduces after he stopped it. There's so much evidence that the keto diet isn't the right diet for cancer patients, it's really a bad situation.

Here are a few more studies related to HER2+ that I posted a week or so ago. Take care!

Black rice bran: Selective Anti-Proliferation of HER2-Positive Breast Cancer Cells by Anthocyanins Identified by High-Throughput Screening
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849376/
Two of the hit compounds, peonidin-3-glucoside and cyaniding-3-glucoside, are both extracts from black rice.

* https://www.bulksupplements.com/products/black-rice-extract-powder

PEITC: Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models.
https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-10-80
(watercress)

Piperine: Antitumor efficacy of Piperine in the treatment of human HER2-overexpressing breast cancer cells
https://pubmed.ncbi.nlm.nih.gov/23870999/

Vitamin K2 MK-4 (menatetrenone): Real-time cell analysis of the inhibitory effect of vitamin K2 on adhesion and proliferation of breast cancer cells.
https://pubmed.ncbi.nlm.nih.gov/26082424/

Psoralen: Natural Compound Attacks HER2 Positive Breast Cancer Cells
https://corporate.dukehealth.org/news/natural-compound-attacks-her2-positive-breast-cancer-cells

Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification
https://pubmed.ncbi.nlm.nih.gov/15642702/

Curcumin: The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162976/
https://www.researchgate.net/figure/The-combination-index-of-herceptin-and-curcumin-treatment-of-the-growth-of-BT-474-cells_tbl1_51604635

Berberine: Growth Suppression of HER2-Overexpressing Breast Cancer Cells by Berberine via Modulation of the HER2/PI3K/Akt Signaling Pathway
https://pubmed.ncbi.nlm.nih.gov/21699261/

Melatonin Represses Metastasis in Her2-Postive Human Breast Cancer Cells by Suppressing RSK2 Expression
https://aacrjournals.org/mcr/article/14/11/1159/126819/Melatonin-Represses-Metastasis-in-Her2-Postive

 

 

 


   
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(@j)
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(@rosed)
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@j Your an angel. Thanks for consolidating all these posts into one.  So wonderful of you. I take melatonin 180 mgs at night.... what do you think of that dose?


   
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(@j)
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Posted by: @rosed

@j Your an angel. Thanks for consolidating all these posts into one.  So wonderful of you. I take melatonin 180 mgs at night.... what do you think of that dose?

Here's an interesting study in mice:

Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice {studytreatment with low dose melatonin (2mg/l for 5 consecutive days every month) significantly decreased spontaneous tumor incidence (by 1,9-fold), mainly mammary carcinomas, in mice whereas higher doses (20mg/l) failed to influence tumor incidence as compared to controls.

I haven't seen convincing data to support the higher dose. One thing I've become aware of is that most Naturopath just as oncologists are in it for the money, and for alternative medicine that often means "higher doses", so you need to get an IV of cheap vitamin C or Curcumin (and end up paying a fortune) etc.

 

 


   
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(@j)
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Posted by: @j

Posted by: @rosed

@j Your an angel. Thanks for consolidating all these posts into one.  So wonderful of you. I take melatonin 180 mgs at night.... what do you think of that dose?

Here's an interesting study in mice:

Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice {studytreatment with low dose melatonin (2mg/l for 5 consecutive days every month) significantly decreased spontaneous tumor incidence (by 1,9-fold), mainly mammary carcinomas, in mice whereas higher doses (20mg/l) failed to influence tumor incidence as compared to controls.

I haven't seen convincing data to support the higher dose. One thing I've become aware of is that most Naturopath just as oncologists are in it for the money, and for alternative medicine that often means "higher doses", so you need to get an IV of cheap vitamin C or Curcumin (and end up paying a fortune) etc.

 

 

@rosed In my view, 15mg is a good dose. That's the dose my father-in-law took, it's what Ben Williams took.

 


   
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(@j)
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Evening Dosing of Melatonin May Prolong Survival in Non–Small Cell Lung Cancer Patients. Results from a placebo-controlled, randomized, double-blind, 3-arm clinical trial.
"In the nighttime melatonin group, there was a statistically significant (P=0.031) decreased overall survival hazard ratio of 39% compared to the placebo group. The placebo group had a median survival of 10.4 months, whereas the nighttime melatonin group had a median survival of 17.6 months." {ref}
 
the dose was 20mg, almost doubling survival at that dose.

   
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(@rosed)
Joined: 2 years ago
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@j I will adjust..... save some dollars.  Thanks!  Over the weekend, I am going to retype all my supplements so you can have a look and tell me what you think.  Since they screwed me with this biopsy seeding, I am more determined than ever to battle this.     And sadly, very few doctors are devoted to healing anymore..... it is a job, not a calling.... like it used to be.  I even think of the medicine men of indigenous cultures and the Chinese and Ayurvedic healers........ sounds like they were tons more invested in their patients' healing.  Thank you for being a "cyber healer"..... just the way you respond to people on this blog as I have seen on so many occasions...... the informative links you provide are great...... but your genuine interest and care for people you never met is also a very special human touch of healing.  God bless you.


   
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(@j)
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@rosed 

we're in big trouble if we don't start caring for each other like so many people who came before us did. You mention some great examples. The last few years have shown how bad things have become. There's no "care" in Health Care anymore, it's just business. 


   
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(@j)
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@rosed 

10 grams of melatonin for just us$13:

https://www.bulksupplements.com/products/melatonin-powder

At 20mg per day that'll last 500 days!

 


   
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(@j)
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10mg scoop https://www.amazon.com/10mg-scoop/s?k=10mg+scoop


   
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(@j)
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side note, this is music from 300 years ago: https://music.youtube.com/watch?v=3yIcoPrAgvs

We're conditioned to think modern is better. Sometimes it's not. 


   
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(@j)
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Melatonin: A Powerful Integrative Adjunctive Agent for Oncology

https://www.scirp.org/journal/paperinformation.aspx?paperid=103190

Various types of cancer are responsive to melatonin treatment in-vitro and in-vivo at daily doses of 10 - 50 mg.

A study of fourteen patients with tamoxifen-resistant, metastatic breast cancer demonstrated that 20 mg of melatonin could have a positive effect. In 28 percent of those patients, a partial response was seen where the disease was expected to progress rapidly, and in those who responded significantly lower serum levels of tumor growth factor IGF-1 were recorded (p < 0.001). The tumor factor response was independent of estrogen-receptor status "

Lissoni, P., et al. (1995) Modulation of Cancer Endocrine Therapy by Melatonin: A Phase II Study of Tamoxifen plus Melatonin in Metastatic Breast Cancer Patients Progressing under Tamoxifen Alone. British Journal of Cancer, 71, 854.
https://doi.org/10.1038/bjc.1995.164


   
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(@j)
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Ammonia Drives Dendritic Cells into Dysfunction

https://www.researchgate.net/publication/264642220_Ammonia_Drives_Dendritic_Cells_into_Dysfunction


   
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(@rosed)
Joined: 2 years ago
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@j Good day, Johan...... just got my blood work back and it shows my IGF levels are above range.  I am going to be 52 in September, and my IGF level was 245 ng/ml.  I know that fasting is one way to get this down.... but that is just a temporary fix.  I was wondering if you had some ideas for me.  it is such a tricky thing.... so much conflicting research.  I feel like some factor the cancer produces is able to raise the IGF to further the proliferation and prevent apoptosis and that it is not a natural IGF process that is causing the cancer.  That is just my gut.  Uggh....... I wonder should I go in to the desert for 40 days.  I am 5'4" and I weigh 116 lb, so it is not like I can really cut back.....    and I do not think an all vegetable Ketogenic diet is going to be sustainable or a good idea for TNBC.   So frustrating. I know the IGF is bad, but I feel like the cancer is causing it to be elevated and I wish I could block it.  Any ideas would be appreciated!!!!!!


   
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(@rosed)
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yes, indeed...... such beautiful creativity and feeling in that piece...... gorgeous...... we need to get back to being fully human. 


   
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(@j)
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Posted by: @rosed

@j Good day, Johan...... just got my blood work back and it shows my IGF levels are above range.  I am going to be 52 in September, and my IGF level was 245 ng/ml.  I know that fasting is one way to get this down.... but that is just a temporary fix.  I was wondering if you had some ideas for me.  it is such a tricky thing.... so much conflicting research.  I feel like some factor the cancer produces is able to raise the IGF to further the proliferation and prevent apoptosis and that it is not a natural IGF process that is causing the cancer.  That is just my gut.  Uggh....... I wonder should I go in to the desert for 40 days.  I am 5'4" and I weigh 116 lb, so it is not like I can really cut back.....    and I do not think an all vegetable Ketogenic diet is going to be sustainable or a good idea for TNBC.   So frustrating. I know the IGF is bad, but I feel like the cancer is causing it to be elevated and I wish I could block it.  Any ideas would be appreciated!!!!!!

@rosed Hi Rosaleen, how does this latest result compare to previous blood work? I agree that a ketogenic diet isn't a good option for TNBC. Increasing carbs and lowering protein should help. I'd also ask your oncologist to give you a prescription for Tamoxifen. Sodium selenite seems very useful as does Luteolin.

Tamoxifen
https://pubmed.ncbi.nlm.nih.gov/9205064/

Sodium selenite
https://elifesciences.org/articles/62483

Luteolin
https://pubmed.ncbi.nlm.nih.gov/22799344/

 


   
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(@j)
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Posted by: @j

Posted by: @rosed

@j Good day, Johan...... just got my blood work back and it shows my IGF levels are above range.  I am going to be 52 in September, and my IGF level was 245 ng/ml.  I know that fasting is one way to get this down.... but that is just a temporary fix.  I was wondering if you had some ideas for me.  it is such a tricky thing.... so much conflicting research.  I feel like some factor the cancer produces is able to raise the IGF to further the proliferation and prevent apoptosis and that it is not a natural IGF process that is causing the cancer.  That is just my gut.  Uggh....... I wonder should I go in to the desert for 40 days.  I am 5'4" and I weigh 116 lb, so it is not like I can really cut back.....    and I do not think an all vegetable Ketogenic diet is going to be sustainable or a good idea for TNBC.   So frustrating. I know the IGF is bad, but I feel like the cancer is causing it to be elevated and I wish I could block it.  Any ideas would be appreciated!!!!!!

@rosed Hi Rosaleen, how does this latest result compare to previous blood work? I agree that a ketogenic diet isn't a good option for TNBC. Increasing carbs and lowering protein should help. I'd also ask your oncologist to give you a prescription for Tamoxifen. Sodium selenite seems very useful as does Luteolin.

Tamoxifen
https://pubmed.ncbi.nlm.nih.gov/9205064/

Sodium selenite
https://elifesciences.org/articles/62483

Luteolin
https://pubmed.ncbi.nlm.nih.gov/22799344/

 

@rosed Although in this study they found different forms of selenium had varying effects on breast cancer:

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.28224

"mice fed the SeMet (selenomethionine) diet showed the least amount of cancer growth at metastatic sites"

In this study, sodium selenite exacerbated cancer metastasis. So probably not a good option even though it can reduce IGF.

 


   
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(@rosed)
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@jI have had 5 tests of IGF...... 4 out of the 5 were high. I am starting 3-day water fast.  I did this awhile ago...... I was fine...... just need to get myself mentally psyched.  I am going to starve those rogue cells.  They are too fat and happy now.  They are in for it. hahahahah.    I am going to ask for tamoxifen.  Funny this morning I read about selenium and came up with completely contradictory papers, so I agree with you.... that's out.   But I did read something about estrogen stimulating IGF....... SO I AM GOING TO GET TAMOXIFEN......gonna contact integrative onco now.  THank you so much for giving me this paper to send to her. I will also up my Luteolin!!!!  Thanks so much!


   
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(@j)
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@rosed Yes estrogen will do that, I really hope she agrees to give you a prescription for tamoxifen. 

Synergistic inhibition of drug resistant breast cancer cells growth by the combination of luteolin and tamoxifen involves Nrf2 downregulation

https://www.jocpr.com/abstract/synergistic-inhibition-of-drug-resistant-breast-cancer-cells-growth-by-the-combination-of-luteolin-and-tamoxifen-involve-6169.html

Synergistic apoptotic effect of celecoxib and luteolin on breast cancer cells

https://www.researchgate.net/publication/233891877_Synergistic_apoptotic_effect_of_celecoxib_and_luteolin_on_breast_cancer_cells

Celecoxib inhibits insulin-like growth factor 1 induced growth and invasion in non-small cell lung cancer https://www.researchgate.net/publication/247153548_Celecoxib_inhibits_insulin-like_growth_factor_1_induced_growth_and_invasion_in_non-small_cell_lung_cancer


   
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(@j)
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Posted by: @j

@rosed Yes estrogen will do that, I really hope she agrees to give you a prescription for tamoxifen. 

Synergistic inhibition of drug resistant breast cancer cells growth by the combination of luteolin and tamoxifen involves Nrf2 downregulation

https://www.jocpr.com/abstract/synergistic-inhibition-of-drug-resistant-breast-cancer-cells-growth-by-the-combination-of-luteolin-and-tamoxifen-involve-6169.html

Synergistic apoptotic effect of celecoxib and luteolin on breast cancer cells

https://www.researchgate.net/publication/233891877_Synergistic_apoptotic_effect_of_celecoxib_and_luteolin_on_breast_cancer_cells

Celecoxib inhibits insulin-like growth factor 1 induced growth and invasion in non-small cell lung cancer https://www.researchgate.net/publication/247153548_Celecoxib_inhibits_insulin-like_growth_factor_1_induced_growth_and_invasion_in_non-small_cell_lung_cancer

more possible synergistic anticancer effects in combination with celecoxib (see image)

 

 


   
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