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(@rosed)
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@j I will be going for zoledronic acid iv tomorrow..... in your opinion, which would be better..... nascent iodine or potassium iodine and iodide?  Thanks!

-Rosaleen


   
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(@j)
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Posted by: @rosed

@j I will be going for zoledronic acid iv tomorrow..... in your opinion, which would be better..... nascent iodine or potassium iodine and iodide?  Thanks!

-Rosaleen

Hi @RosaleenD, wonderful!  In the study it says:

"Iodine was dissolved with potassium iodide (1:2) in double-distilled
water. The amount of I2 was estimated using the sodium
thiosulfate titration method, and the stock solution of
75 mM (~20.0 mg/L) I2 was prepared"

Good luck!!

J

 

 

 


   
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(@j)
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Quick note, I added a few diagrams and synergistic combinations, here's the link again:

https://synergiesforcancertreatments.blogspot.com/p/triple-negative-breast-cancer-tnbc.html


   
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(@rosed)
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@j I will be going for zoledronic acid iv tomorrow..... in your opinion, which would be better..... nascent iodine or potassium iodine and iodide?  Thanks!

-Rosaleen

 


   
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(@rosed)
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@j Thanks!   Sorry.... I think i double posted this.  uggh. Thank you so so much for your reply.

 


   
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(@rosed)
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Any opinions on whole-body cryotherapy????

Seki, T., Yang, Y., Sun, X. et al. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature 608, 421–428 (2022). https://doi.org/10.1038/s41586-022-05030-3


   
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(@rosed)
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@j These diagrams and the articles are blowing my mind. They are lightening my heavy heart this morning!  You are an amazing person to be doing this. I am so grateful. Gotta go buy some coffee! 😊


   
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(@j)
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Posted by: @rosed

Any opinions on whole-body cryotherapy????

Seki, T., Yang, Y., Sun, X. et al. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature 608, 421–428 (2022). https://doi.org/10.1038/s41586-022-05030-3

I like it! I don't like the use of heat in cancer (hot baths, sauna), heat can increase ammonia which I believe should be kept as low as possible. 

 

 


   
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(@j)
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Posted by: @rosed

@j Thanks!   Sorry.... I think i double posted this.  uggh. Thank you so so much for your reply.

 

 

In the following study, they used regular oral iodine:

Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study https://www.mdpi.com/2072-6643/11/7/1623

Five-year disease-free survival rate was significantly higher in patients treated with the I2 supplement before and after surgery compared to those receiving the supplement only after surgery (82% versus 46%). I2-treated tumors exhibit less invasive potential, and significant increases in apoptosis, estrogen receptor expression, and immune cell infiltration. Transcriptomic analysis indicated activation of the antitumoral immune response. The results led us to register a phase III clinical trial to analyze chemotherapy + I2 treatment for advanced breast cancer.

Colloidal iodine also has some good studies to support its use. Looks like all forms are beneficial in cancer treatment.

 

 


   
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(@j)
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"He that despises the little is not worthy of the great." A year ago I was experimenting with citric acid, I started with a gram for a few days, then increased the dose and when I got to 4 grams I noticed I was experiencing anxiety, I emailed Daniel if he knew of people experiencing the same and he told me no but that he didn't know of anybody using citric acid either. Citric acid is very cheap and very easy to take, just a few grams in water or juice. Same for bicarbonate, here's what just 4 grams of equally cheap bicarbonate did for pancreas cancer patients:

Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer:

Twenty-eight patients with metastatic or recurrent pancreatic cancer were assessed in this study. Alkalization therapy consisted of an alkaline diet with supplementary oral sodium bicarbonate (3.0-5.0 g/day). Results: The mean urine pH was significantly higher after the alkalization therapy (6.85±0.74 vs. 6.39±0.92; p<0.05). The median overall survival from the start of alkalization therapy of the patients with high urine pH (>7.0) was significantly longer than those with low urine pH (≤ 7.0) (16.1 vs. 4.7 months; p<0.05).


   
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(@j)
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Targeting hypoxia-inducible factor-1alpha: A new strategy for triple-negative breast cancer therapy
 
Lactobacilli Modulate Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway in Triple Negative Breast Cancer Cell Line
 
"Although it is believed that lactic acid, produced by cancer cells, plays a pivotal role in the development of malignancies (21) and HIF-1 activation, as well as triggering tumor growth and angiogenesis (22), producing this bacterial organic compound has been considered to exert anticancer effects for a long time. However, the exact mechanism of cytotoxic effects of lactobacilli on cancer cells is not obvious yet. Studies have shown that the effect of lactobacilli is different in malignant compared to the normal cells with the same origin (23). Consistent with such studies, we demonstrated that the presented lactobacilli (L. crispatus and L. rhamnosus) supernatants have cytotoxic effects on cancer, but not on normal fibroblast cells. ...
our present findings, regarding the HIF-1α downregulation due to the LRS treatment, suggest that L. rhamnosus might be served as a HIF inhibitor in therapeutic regimens."

   
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(@j)
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updated diagram


   
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(@rosed)
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 🤔 So. AC-T chemos May--Oct 2021, followed by double mastectomy in November 2021.  January 2023 - recurrence at same location of original tumor. Pet scan showed small lesion on lung.  Surgery to remove both last Monday. Yesterday, my pathology report appeared on MyChart.     SHOCK........ both breast and lung lesions tested Her 2 positive!!!!  (IHC test showed 3+ for Her 2)

So I guess I am now still fighting TNBC and now Her2+.    I have to always make things complicated! 😜 

Johan, do most of these TNBC synergies work for both? 🧐 Thanks so much!

 

-Rosaleen 


   
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(@j)
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Posted by: @rosed

 🤔 So. AC-T chemos May--Oct 2021, followed by double mastectomy in November 2021.  January 2023 - recurrence at same location of original tumor. Pet scan showed small lesion on lung.  Surgery to remove both last Monday. Yesterday, my pathology report appeared on MyChart.     SHOCK........ both breast and lung lesions tested Her 2 positive!!!!  (IHC test showed 3+ for Her 2)

So I guess I am now still fighting TNBC and now Her2+.    I have to always make things complicated! 😜 

Johan, do most of these TNBC synergies work for both? 🧐 Thanks so much!

 

-Rosaleen 

Hi Rosaleen, yes it happens and it can happen because of how cancer reacts to treatments. These synergies will indeed work for both, this does make it more likely that tamoxifen and especially synergistic combinations with tamoxifen will have a greater chance of treatment success! My father-in-law has been taking tamoxifen since 2003, so that's now 20 years (he had glioblastoma)! And of course, there are other treatment options for Her2+

J

 


   
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(@j)
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Posted by: @j

Posted by: @rosed

 🤔 So. AC-T chemos May--Oct 2021, followed by double mastectomy in November 2021.  January 2023 - recurrence at same location of original tumor. Pet scan showed small lesion on lung.  Surgery to remove both last Monday. Yesterday, my pathology report appeared on MyChart.     SHOCK........ both breast and lung lesions tested Her 2 positive!!!!  (IHC test showed 3+ for Her 2)

So I guess I am now still fighting TNBC and now Her2+.    I have to always make things complicated! 😜 

Johan, do most of these TNBC synergies work for both? 🧐 Thanks so much!

 

-Rosaleen 

Hi Rosaleen, yes it happens and it can happen because of how cancer reacts to treatments. These synergies will indeed work for both, this does make it more likely that tamoxifen and especially synergistic combinations with tamoxifen will have a greater chance of treatment success! My father-in-law has been taking tamoxifen since 2003, so that's now 20 years (he had glioblastoma)! And of course, there are other treatment options for Her2+

J

 

Tamoxifen is an old drug that's why there are so many studies indicating possible synergies, for example with ursolic acid. There are a few that are not on the chart, for example, baicalein, which is an hif1 alpha inhibitor. Plenty of options!

 

 


   
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(@j)
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Posted by: @j

Posted by: @j

Posted by: @rosed

 🤔 So. AC-T chemos May--Oct 2021, followed by double mastectomy in November 2021.  January 2023 - recurrence at same location of original tumor. Pet scan showed small lesion on lung.  Surgery to remove both last Monday. Yesterday, my pathology report appeared on MyChart.     SHOCK........ both breast and lung lesions tested Her 2 positive!!!!  (IHC test showed 3+ for Her 2)

So I guess I am now still fighting TNBC and now Her2+.    I have to always make things complicated! 😜 

Johan, do most of these TNBC synergies work for both? 🧐 Thanks so much!

 

-Rosaleen 

Hi Rosaleen, yes it happens and it can happen because of how cancer reacts to treatments. These synergies will indeed work for both, this does make it more likely that tamoxifen and especially synergistic combinations with tamoxifen will have a greater chance of treatment success! My father-in-law has been taking tamoxifen since 2003, so that's now 20 years (he had glioblastoma)! And of course, there are other treatment options for Her2+

J

 

Tamoxifen is an old drug that's why there are so many studies indicating possible synergies, for example with ursolic acid. There are a few that are not on the chart, for example, baicalein, which is an hif1 alpha inhibitor. Plenty of options!

 

 

@rosaleend

https://foodforbreastcancer.com/articles/foods-to-eat-and-avoid-for-her2%2B-patients-and-survivors

 


   
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(@j)
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the link I posted above has some contradictions e.g. apigenin (amplifies the effects of Herceptin but is also listed as a supplement to avoid in ER+/PR+/HER2+ because of estrogenic properties, not sure what to make of it. This is one of the reasons why I always look for synergistic combinations. Anyway, worth taking into account.


   
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(@j)
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Dorsomorphin + Aspirin

Compound C (Dorsomorphin) enhances the anticancer effect of aspirin in HER-2-positive breast cancer by regulating lipid metabolism in an AMPK-independent pathway

https://www.ijbs.com/v16p0583.htm


   
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(@j)
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Posted by: @j

Dorsomorphin + Aspirin

Compound C (Dorsomorphin) enhances the anticancer effect of aspirin in HER-2-positive breast cancer by regulating lipid metabolism in an AMPK-independent pathway

https://www.ijbs.com/v16p0583.htm

"Combined aspirin and Compound C treatment has a strong synergistic effect against growth of HER-2-positive breast tumors in mice" 

(see attachment)

 


   
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(@j)
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Posted by: @j

the link I posted above has some contradictions e.g. apigenin (amplifies the effects of Herceptin but is also listed as a supplement to avoid in ER+/PR+/HER2+ because of estrogenic properties, not sure what to make of it. This is one of the reasons why I always look for synergistic combinations. Anyway, worth taking into account.

Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708008/

The attached table sheds more light on the issue. ++++ is representative of 100% suppression of estradiol (1 nM)-induced proliferation as seen with tamoxifen (100 nM). Compounds with weaker activity are represented as +++.

https://www.researchgate.net/publication/11819574_Estrogenic_and_Antiestrogenic_Activities_of_FlavonoidPhytochemicals_Through_Estrogen_ReceptorBinding-Dependent_and_-Independent_Mechanisms

Apigenin was shown to possess anti-estrogenic activities which may be mediated through ER binding-dependent and independent mechanisms

 


   
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(@j)
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@rosaleend 

emodin and HER2+

emodin blocks her2 phosphorylation and its intracellular signaling (see attachment)

Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312285/

 

 

 


   
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(@j)
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Posted by: @rosed

 🤔 So. AC-T chemos May--Oct 2021, followed by double mastectomy in November 2021.  January 2023 - recurrence at same location of original tumor. Pet scan showed small lesion on lung.  Surgery to remove both last Monday. Yesterday, my pathology report appeared on MyChart.     SHOCK........ both breast and lung lesions tested Her 2 positive!!!!  (IHC test showed 3+ for Her 2)

So I guess I am now still fighting TNBC and now Her2+.    I have to always make things complicated! 😜 

Johan, do most of these TNBC synergies work for both? 🧐 Thanks so much!

 

-Rosaleen 

@rosaleend

This seems to happen more often than not, 8 out of 13 initially triple-negative patients (61.5%) had a change to positive status of either ER, PR, or HER2.{ref}

I'm cross-checking between TNBC and HER2+ to find out if any of the substances shown on the TNBC shart should be avoided in case of HER2+ but so far all good 🙂

I've attached a chart with some additional options.

 


   
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(@j)
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Ornithine and breast cancer: a matched case–control study

"The average age for cases and controls were 49.6 years (standard deviation [SD] 8.7 years) and 48.9 years (SD 8.7 years), respectively. Each SD increase in ornithine levels was associated with a 12% reduction of breast cancer risk (adjusted odds ratio [OR] 0.88; 95% confidence interval [CI] 0.79–0.97). The association between ornithine and breast cancer did not differ by pathological stages of diagnosis or tumor grades (all P for trend > 0.1). We observed no effect measure modification by molecular subtypes (P for interaction = 0.889). In conclusion, higher ornithine levels were associated with lower breast cancer risk in females."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511971/


   
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(@j)
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https://link.springer.com/article/10.1007/s12672-012-0114-x

"Our data clearly show that apigenin (50 mg/kg) inhibits progression and development of these xenograft tumors by inducing apoptosis, inhibiting cell proliferation, and reducing expression of Her2/neu. Moreover, apigenin reduced levels of vascular endothelial growth factor (VEGF) without altering blood vessel density"

Dose conversion: approx 300mg in 75kg human. In the metformin study 240mg.

 


   
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(@j)
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Albumin-Bound Paclitaxel

"The objective response rate (ORR) was also significantly greater in nab- paclitaxel than in CrEL-paclitaxel recipients (33% vs 19%)."


   
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(@j)
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@rosaleend @chris48 @jens

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function

https://www.nature.com/articles/srep13605

The most aggressive tumour cells, which often reside in hypoxic environments, rely on glycolysis for energy production. Thereby they release vast amounts of lactate and protons via monocarboxylate transporters (MCTs), which exacerbates extracellular acidification and supports the formation of a hostile environment. We have studied the mechanisms of regulated lactate transport in MCF-7 human breast cancer cells. Under hypoxia, expression of MCT1 and MCT4 remained unchanged, while expression of carbonic anhydrase IX (CAIX) was greatly enhanced. Our results show that CAIX augments MCT1 transport activity by a non-catalytic interaction. Mutation studies in Xenopus oocytes indicate that CAIX, via its intramolecular H+-shuttle His200, functions as a “proton-collecting/distributing antenna” to facilitate rapid lactate flux via MCT1. Knockdown of CAIX significantly reduced proliferation of cancer cells, suggesting that rapid efflux of lactate and H+, as enhanced by CAIX, contributes to cancer cell survival under hypoxic conditions.

Acetazolamide is a carbonic anhydrase inhibitor, you'll find it on the chart, and has some good options for synergistic effects.

 


   
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(@j)
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Acetazolamide + SULF

Acetazolamide + RAPA

 


   
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(@j)
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it´s cheap and is also used for mountain sickness.


   
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(@j)
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The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827615/

40mg/kg, conversion to human dose approx 240mg 75kg person.

In a glioblastoma xenograft mouse model 20mg/kg was more effective than the standard chemotherapy treatment, approx 120mg 75kg person.

https://www.researchgate.net/publication/325884610_Safety_and_Toxicology_of_Magnolol_and_Honokiol

In vitro and in vivo genotoxicity studies indicated that concentrated MBE has no mutagenic and genotoxic potential, while a subchronic study performed according to OECD (Organisation for Economic Co-operation and Development) guidelines established a no adverse effect level for concentrated MBE > 240 mg/kg b.w/d. Similar to other dietary polyphenols, magnolol and honokiol are subject to glucuronidation, and despite a relatively quick clearance, an interaction with pharmaceutical active principles or other herbal constituents cannot be excluded. However, intervention trials employing concentrated MBE for up to 1 y did not report adverse effects. In conclusion, over the recent years different food safety authorities evaluated magnolol and honokiol and considered them safe.


   
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(@j)
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US$33 for 10 grams https://liftmode.com/magnolol-powder/#1g


   
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