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TNBC / testing strategies in a NED situation

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(@j)
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This paragraph provides great insight into the challenges associated with some of the different strategies for treating cancer in this thread:
 
"While some cancer treatments induce high ROS levels to kill tumor cells, nonlethal increase of ROS may facilitate tumor progression and metastasis (7, 49). A similar concept applies to our present findings, in which NDUFV1 knockdown caused complex I deficiency but did not drastically inhibit OXPHOS. While not affecting cell viability, NDUFV1 knockdown significantly enhanced metastatic activity. Thus, it should be noted that strategies aimed at killing tumor cells by interfering with mitochondrial functions or NAD+ synthesis could, if not effectively lethal, inadvertently produce even more aggressive tumor cell phenotypes. Thus, in the long run, approaches aimed at normalizing mitochondrial functions, particularly complex I activity and NAD+/NADH redox levels, could be therapeutically more effective and safer and would not interfere with normal cell function."

   
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Targeting Tumor Acidosis and Regulatory T Cells Unmasks Anti-Metastatic Potential of Local Tumor Ablation in Triple-Negative Breast Cancer

https://www.mdpi.com/1422-0067/23/15/8479/htm

Oral bicarbonate (administered via drinking water) was an important part of the success of this treatment.

 

"While both cyclo and bicarb moderately increased rates of survival after ECE ablation, the combination of all three agents (bicarbonate, cyclophosphamide, and ECE ablation), which we refer to as BiCyclA, produced the most striking increase in survival across three murine models of TNBC, supporting our hypothesis. We found that local therapy, specifically ECE ablation and not surgical excision, was crucial for producing the systemic anti-tumor response to BiCyclA. "

 


   
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(@j)
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Here's another update to the diagram, I'll leave it at that but of course, one can expand on this concept of synergies, in my view, it should invariably lead to the application of the most effective combinations. I added fisetin as it's another interesting anticancer compound and effective also in TNBC and should be a good addition to HDAC inhibitors such as butyrate etc.


   
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Regarding the combination of curcumin and egcg, this combination has shown synergistic effects in several cancer types, interestingly sequential treatment of those compounds proved 3 to 4 fold more effective in leukemia (ref), either curcumin then egg¿cg, or egcg then curcumin proved more effective then co-administration, with the egcg followed by curcumin administration likely as the best option. So it might be worth supplementing these substances every other day e.g. Monday egcg, Tuesday curcumin and so on.


   
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(@j)
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Posted by: @j

Regarding the combination of curcumin and egcg, this combination has shown synergistic effects in several cancer types, interestingly sequential treatment of those compounds proved 3 to 4 fold more effective in leukemia (ref), either curcumin then egg¿cg, or egcg then curcumin proved more effective then co-administration, with the egcg followed by curcumin administration likely as the best option. So it might be worth supplementing these substances every other day e.g. Monday egcg, Tuesday curcumin and so on.

I've edited the diagram to reflect this

 


   
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(@j)
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Posted by: @j

Regarding the combination of curcumin and egcg, this combination has shown synergistic effects in several cancer types, interestingly sequential treatment of those compounds proved 3 to 4 fold more effective in leukemia (ref), either curcumin then egg¿cg, or egcg then curcumin proved more effective then co-administration, with the egcg followed by curcumin administration likely as the best option. So it might be worth supplementing these substances every other day e.g. Monday egcg, Tuesday curcumin and so on.

I've edited the diagram to reflect this

 


   
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(@j)
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Dose conversion metformin + apigenin study in TNBC model:

760.14 mg METFORMIN
243.24 mg APIGENIN

75KG person

 


   
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FYI, 1 gram of dried parsley provides about 130mg of apigenin, and Daniel has a liposomal formula @ MCSFromulas providing 200mg of apigenin.


   
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Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness

https://www.sciencedirect.com/science/article/pii/S1756464622002894

mice got PTE for 26 days 50mg/kg, intra-gastric admin. (I believe this is quite similar to oral admin as far as dose conversion is concerned). approx 300mg for a 75kg human.

 

Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion

https://pubmed.ncbi.nlm.nih.gov/23417847/

Also in other cancer types PTE and IP6 are synergistic anticancer.


   
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Countering Triple Negative Breast Cancer via Impeding Wnt/β-Catenin Signaling, a Phytotherapeutic Approach

https://www.researchgate.net/publication/362911836_Countering_Triple_Negative_Breast_Cancer_via_Impeding_Wntb-Catenin_Signaling_a_Phytotherapeutic_Approach

Worth a read, one that I like is naringin.


   
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(@j)
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Posted by: @j

Posted by: @j

Regarding the combination of curcumin and egcg, this combination has shown synergistic effects in several cancer types, interestingly sequential treatment of those compounds proved 3 to 4 fold more effective in leukemia (ref), either curcumin then egg¿cg, or egcg then curcumin proved more effective then co-administration, with the egcg followed by curcumin administration likely as the best option. So it might be worth supplementing these substances every other day e.g. Monday egcg, Tuesday curcumin and so on.

I've edited the diagram to reflect this

 

Some further editions to the diagram (see attachment) and I've posted to my blog so it can be viewed without being logged in to the forum:

https://synergiesforcancertreatments.blogspot.com/p/triple-negative-breast-cancer-tnbc.html

 

 

 


   
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(@j)
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I've updated the chart again, with more synergies. Of course, the objective isn't to take so many different substances simultaneously, the diagram just points to options at every step. Hope this helps!


   
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@jens @chris48 @rosaleenD

Rapamycin Plus Doxycycline Combination Affects Growth Arrest and Selective Autophagy-Dependent Cell Death in Breast Cancer Cells

"The rapamycin + doxycycline combination was more effective than traditional chemotherapy—doxorubicin—or the used rapamycin monotherapy in the in vivo experiments (Figure 3b). The withdrawal and further in vivo treatments were also tested, which showed that continuous treatment could cause significant survival benefits in vivo. "

 


   
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(@rosed)
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@j Thanks Johan..... just home from my breast recurrence and lung spot.... a two for one. I HATE TNBC!!!!!!!!!!  Thank you so much for all these possible weapons. I will defo look in to Rapamycin. Heading up to rest..... knoclked out. I feel like a wounded warrior. Third time the scalpel has torn into my breast area. Now my poor lung too.  BUT I WILL KEEP FIGHTING.  Thank you for being on our side.


   
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(@j)
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@rosaleend I'm sorry you're in this situation. I hope you can get the time and help to rest and recover from surgery. Take care!

J


   
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@j It's morning, I am feeling good.   Yes!  Rapamycin...... IGF!!!!!!!   Interesting citrate also tangled up with IGF.........       me thinks I would like to be a little IGF experiment, hahahahahah........       Wouldn't it be something else if adding citrate to a couple of glasses of water a day could help us in battle........      A girl can dream.        It ain't all genetic, it ain't all receptor based, it ain't all immuno based, and it is very hard for cancer patients enduring surgeries and treatments to go ketotarian...... eating like an Italian cow..... greens with olive oil.    There have to be a few things to jump in and hijack that IGF pathway...... put some spokes in wheel.   

 

 


   
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(@j)
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@rosaleend great to hear you are feeling good this morning! Citric acid is one of many great options to try, IMO. Dr Halabe cured quite a few cancer patients using only citric acid. Studies have since confirmed the anticancer activity of citric acid. I think citric acid affects cancer in many ways, including IGF, pH (CA converts to bicarbonate), lowers ammonia, ... .


   
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(@j)
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Posted by: @j

@rosaleend great to hear you are feeling good this morning! Citric acid is one of many great options to try, IMO. Dr Halabe cured quite a few cancer patients using only citric acid. Studies have since confirmed the anticancer activity of citric acid. I think citric acid affects cancer in many ways, including IGF, pH (CA converts to bicarbonate), lowers ammonia, ... .

Btw, about keto, in this study they found a 20% increase in survival time by combining rapamycin with KD compared to a Standard Diet (SD), in a mouse model. The KD was 0.1% carbohydrates, which I don't think is feasible to replicate, and the SD had 80% carbs but they don't mention what type of carbs. Eating spaghetti and white bread is carbs, but that's not the same as eating fruits and vegetables. I really feel these types of studies are misleading. 

 

 


   
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(@chris48)
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Posted by: @rosed

@j Thanks Johan..... just home from my breast recurrence and lung spot.... a two for one. I HATE TNBC!!!!!!!!!!  Thank you so much for all these possible weapons. I will defo look in to Rapamycin. Heading up to rest..... knoclked out. I feel like a wounded warrior. Third time the scalpel has torn into my breast area. Now my poor lung too.  BUT I WILL KEEP FIGHTING.  Thank you for being on our side.

I am so sorry! Please keep your amazing spirit! I really believe that we are getting closer and closer to be able to heal mTNBC. Even if all those strategies from this website might not completely kill every single cancer cell, they might slow down the progression until finally a cure is available. Please keep us posted about what you are doing - maybe someone here has a helpful idea.

 

All the best,
Christian

 


   
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Posted by: @j

I've updated the chart again, with more synergies. Of course, the objective isn't to take so many different substances simultaneously, the diagram just points to options at every step. Hope this helps!

I love those charts and I can't thank you enough for your work! I think it is really helpful to have this for specififc cancer types and subtypes. Based on your input we will add apigenin, luteolin and curcumin to the protocol. 

 


   
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Posted by: @chris48

Posted by: @j

I've updated the chart again, with more synergies. Of course, the objective isn't to take so many different substances simultaneously, the diagram just points to options at every step. Hope this helps!

I love those charts and I can't thank you enough for your work! I think it is really helpful to have this for specififc cancer types and subtypes. Based on your input we will add apigenin, luteolin and curcumin to the protocol. 

 

Thank you, @chris48. Best of luck!

 


   
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Study says antidepressant could inhibit breast cancer

https://www.taipeitimes.com/News/taiwan/archives/2019/08/09/2003720184

Bupropion is a nicotinic receptor antagonist. Cyproheptadine might be useful. And as mentioned already, niacin/nicotinamide.


   
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@j Hi Johan.

I wanted to say thank you for all your hard work.  If I don't say it  more often please remember we are all grateful for your help. As you know my wife Lourdes is being treated with  the IT OV virus. We are waiting for the third treatment still in Germany. Per your  input we have stopped the Lansoprazole and Metformin combination for the neuropathy in her feet and hands. Unfortunately she also stopped everything I was giving her due stress I guess. I was looking for a nurse here to administer the 2 DG and IVC at our house but just can't seem to find one. Any suggestions would appreciated. Also  I was following Daniels Shutting Down the Mitochondria strategy as much as  possible. but do the neuropathy i wasn't certain some of the combinations were the cause( Metformin/Lansoprazole/ Atorvastatin/ Diclofenic). Prior to her stopping everything I was switching to more of the natural substances. 

I saw you posted (rapamycin + doxycycline combination was more effective than traditional chemotherapy) 

It seems very interesting.  I stopped her using Doxycycline and Azithromycin  when we started the Ov due to the gut microbe issues. I am wondering if it  would be should be added again on a pulsing basis?

Thanks Johan. The charts are amazing...


   
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I previously posted about my concern regarding the use of Loratadine, based on a Canadian study which showed that mice that had received the antihistamines loratadine, astemizole and hydroxyzine had tumor weights of 150% to 390% greater than mice in control groups, the researchers reported. The doses were equivalent to those commonly prescribed for humans (10mg).

In a study in colon cancer, they found LOR could slow tumor growth (compared to DMSO control) note that the human equivalent dose used in that study is much higher, ~ 150mg.


   
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Posted by: @jens

@j Hi Johan.

I wanted to say thank you for all your hard work.  If I don't say it  more often please remember we are all grateful for your help. As you know my wife Lourdes is being treated with  the IT OV virus. We are waiting for the third treatment still in Germany. Per your  input we have stopped the Lansoprazole and Metformin combination for the neuropathy in her feet and hands. Unfortunately she also stopped everything I was giving her due stress I guess. I was looking for a nurse here to administer the 2 DG and IVC at our house but just can't seem to find one. Any suggestions would appreciated. Also  I was following Daniels Shutting Down the Mitochondria strategy as much as  possible. but do the neuropathy i wasn't certain some of the combinations were the cause( Metformin/Lansoprazole/ Atorvastatin/ Diclofenic). Prior to her stopping everything I was switching to more of the natural substances. 

I saw you posted (rapamycin + doxycycline combination was more effective than traditional chemotherapy) 

It seems very interesting.  I stopped her using Doxycycline and Azithromycin  when we started the Ov due to the gut microbe issues. I am wondering if it  would be should be added again on a pulsing basis?

Thanks Johan. The charts are amazing...

Hi Jens, thank you, I think that while she's on IT OV treatment it makes sense to pause the adjuvant drugs and supplements, I don't know how long this treatment will take, I assume it'll depend on the results after the third administration?

The rapamycin + doxy (+ celecoxib) combination is definitely worth pursuing as are other combinations such as apigenin + metformin, metformin + rapamycin, and others I've included on the charts

Maybe something like this (all based on studies showing anticancer synergism):

rapamycin + doxy (+ celecoxib) (+bicarbonate)

next: + metformin (and discontinue celecoxib)

next  + apigenin (with or with or without rapamycin)

 

 


   
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(@j)
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Posted by: @j

Posted by: @jens

@j Hi Johan.

I wanted to say thank you for all your hard work.  If I don't say it  more often please remember we are all grateful for your help. As you know my wife Lourdes is being treated with  the IT OV virus. We are waiting for the third treatment still in Germany. Per your  input we have stopped the Lansoprazole and Metformin combination for the neuropathy in her feet and hands. Unfortunately she also stopped everything I was giving her due stress I guess. I was looking for a nurse here to administer the 2 DG and IVC at our house but just can't seem to find one. Any suggestions would appreciated. Also  I was following Daniels Shutting Down the Mitochondria strategy as much as  possible. but do the neuropathy i wasn't certain some of the combinations were the cause( Metformin/Lansoprazole/ Atorvastatin/ Diclofenic). Prior to her stopping everything I was switching to more of the natural substances. 

I saw you posted (rapamycin + doxycycline combination was more effective than traditional chemotherapy) 

It seems very interesting.  I stopped her using Doxycycline and Azithromycin  when we started the Ov due to the gut microbe issues. I am wondering if it  would be should be added again on a pulsing basis?

Thanks Johan. The charts are amazing...

Hi Jens, thank you, I think that while she's on IT OV treatment it makes sense to pause the adjuvant drugs and supplements, I don't know how long this treatment will take, I assume it'll depend on the results after the third administration?

The rapamycin + doxy (+ celecoxib) combination is definitely worth pursuing as are other combinations such as apigenin + metformin, metformin + rapamycin, and others I've included on the charts

Maybe something like this (all based on studies showing anticancer synergism):

rapamycin + doxy (+ celecoxib) (+bicarbonate)

next: + metformin (and discontinue celecoxib)

next  + apigenin (with or with or without rapamycin)

 

 

@jens in the example outlined above, I forgot to add to discontinue doxy either at step 2 or 3.

 


   
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(@j)
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Posted by: @jens

rapamycin + doxycycline combination was more effective than traditional chemotherapy) 

the human-converted dose used in the study, was approx 30mg doxy and 18mg rapa. this was a rather longer-term treatment of 21 days and another 12 days.

 


   
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(@j)
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Posted by: @jens

I was looking for a nurse here to administer the 2 DG and IVC at our house but just can't seem to find one. Any suggestions would appreciated.

@jens if you can't find a nurse or other health professional maybe try contacting bodybuilders, many are very knowledgeable in the use of IV drips and therapies.

 


   
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Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro

   
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