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TNBC / testing strategies in a NED situation

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johan
(@j)
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Berberine Reverses Breast Cancer Multidrug Resistance Based on Fluorescence Pharmacokinetics In Vitro and In Vivo

"In this work, Ber was demonstrated as an ideal MDR reversing agent. The MDR reversal effect is achieved by inhibiting P-gp and MRP1 functions and their expression in MCF-7/DOXFluc tumor cells. When combininging Ber with DOX to treat DOX-resistant breast cancer, Ber enhanced the intracellular concentration and retention of DOX in tumor cells, which occurred via facilitating the cellular drug uptake and reducing the drug efflux rate in MCF-7/DOXFluc tumor cells. The DOX–Ber combination significantly enhanced the in vivo anticancer efficacy of DOX in a drug-resistant MCF-7/DOXFluc xenograft model."

https://pubs.acs.org/doi/10.1021/acsomega.0c06288#


   
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Daniel
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@j this woudl be a lot for the stomach indeed. Maybe proton pump inhibitors prior to that will help.

However, high dose Aspirin (a few grams at once) is given intravenous as part of the Diflunisal treatment at clinics in Europe including Germany. Diflunisal is a NSAID as Aspirin, so in the end the patient ends up with about 5g of NSAID given intravenously in a few to several hours. In order to lower the chance for potential side effects, they use intravenous Pantoprazole prior to that, as Aspirin and Diflunisal will react stronger in acidic areas (acidity that will be reduced temporarily by the proton pump inhibitor). 

This is indeed known as a powerful anti-cancer treatment with important potential.

Kind regards,
Daniel


   
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johan
(@j)
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@chris48 

Epigenetic restoration and activation of ERβ: an inspiring approach for treatment of triple-negative breast cancer

https://link.springer.com/article/10.1007/s12032-022-01765-1

Conclusions

The antiproliferative effect of ERβ could be retained when co-expressed with Erα using a powerful epigenetic combination of Decitabine and vorinostat with DPN.


   
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Chris48
(@chris48)
Joined: 1 year ago
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Topic starter  
Posted by: @j

"Luteolin inhibits the metastasis of triple-negative breast cancer"
https://foodforbreastcancer.com/news/luteolin-inhibits-the-metastasis-of-triple-negative-breast-cancer

"Sulforaphane inhibits HER2+ and triple-negative breast cancer"
https://foodforbreastcancer.com/news/sulforaphane-inhibits-her2%2B-and-triple-negative-breast-cancer

"Quercetin and fisetin inhibit TN cell migration"
https://foodforbreastcancer.com/news/quercetin-and-fisetin-inhibit-tn-cell-migration

@j Thank you Johan! I was not aware of the effects of Luteolin on TNBC. Very interesting! Thank you also for your input on foods and aspirin - I really appreciate it!


   
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Chris48
(@chris48)
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Thank you @daniel and @j for your help! Her docs would not allow aspirin, but were okay with Ibuprofen before and after the surgery. So, she decided to take those instead, since Ibuprofen seems to have similar effects regarding relapse prevention. Additionally she took arginine based on this study: https://pubmed.ncbi.nlm.nih.gov/20881073/

The surgery went well, but they also cut out some muscle tissue as the tumor was located close to the breast muscle. Now we have to wait ~2 weeks for the lab results to see whether the edges were free of tumor cells.

Anyway, I was wondering if there are any supplements that she should take right now. I mean supplements that are anti-cancer but also helping with the wound healing (or at least don't make it worse). If you have any ideas, please let me know.

All the best,

Christian


   
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johan
(@j)
Joined: 4 years ago
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Posted by: @chris48

Anyway, I was wondering if there are any supplements that she should take right now. I mean supplements that are anti-cancer but also helping with the wound healing (or at least don't make it worse). If you have any ideas, please let me know.

 

Here are some ideas, Chris:

Baking soda
https://www.verywellhealth.com/baking-soda-for-inflammation-5093321

Lycopene
Butyrate
Ellagic acid
Vitamin C from preferably from food sources (Camu Camu, acerola, etc)
Curcumin
Boswellia
DHA
Bovine gelatin
Breathing exercises

There are many options, celecoxib could be very useful also, both as a cox 2 inhibitor and anticancer agent.

Good luck and I hope your wife has a quick recovery from her surgery.


   
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johan
(@j)
Joined: 4 years ago
Posts: 1191
 

A few others: berberine, a good quality borage oil.

 


   
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johan
(@j)
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Innate immunity recovers earlier than acquired immunity during severe postoperative immunosuppression

https://www.medsci.org/v15p0001.htm

"Postoperative immune suppression particularly a loss of cell-mediated immunity is commonly seen after surgery due to an increased release of immune suppressing hormones such as catecholamines, prostaglandins and cortisol depending on the amount of surgical stress and tissue damage"


   
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johan
(@j)
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Posted by: @j

Innate immunity recovers earlier than acquired immunity during severe postoperative immunosuppression

https://www.medsci.org/v15p0001.htm

"Postoperative immune suppression particularly a loss of cell-mediated immunity is commonly seen after surgery due to an increased release of immune suppressing hormones such as catecholamines, prostaglandins and cortisol depending on the amount of surgical stress and tissue damage"

Mistletoe, Chaga, Rosmarinic acid (Rosemary), Cassia cinnamon, and AHCC may boost the immune system and have anticancer properties.


   
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Chris48
(@chris48)
Joined: 1 year ago
Posts: 14
Topic starter  

Hello everyone,

here comes a brief update:

- Surgery went well and the tumor (8x13mm) was cut out with clean edges and no access to blood vessels/lymphetic system.

- 6 weeks after surgery her CTCs are stable at 150 (see attached picture), with less cell fragments detected than before surgery (according to the lab professor, this is a good sign and could mean that those remaining CTCs stem from the removed tumor).

- Due to this unnusual case (having a recurrence in the radiated breast) the "tumor board" (several doctors who weekly discuss each case together) could not aggree on a way forward. One recommended capecitabine, another sacituzumab and her oncologist and senologist recommended to not do any treatment.

- However, we were able to convince her senologist to prescribe us the medications for the COC-protocol (Mebendazole, Atorvastatin, Metformin, Doxycycline), since I feel this could be a better treatment in terms of risk/value ratio.

To me, the COC protocol has comparably little side effects, very promising study results and could be combined with some other drugs/supplements. Sacituzumab and capecitabine on the other hand have quiet strong side effects and are damaging the immune system which I think is important to keep strong.

- Which path would you take in her situation (COC-protocol, sacituzumab, capecitabine, no meds, other)?

- Would you rather do the COC protocol as it is or take those meds and use it for a different startegy (e.g. anti-cholesterol, shut down energy engines)?

- Which supplements would you use to boost efficiency of the COC protocol?

 

Of course I am also grateful for any other comments or ideas!

 

All the best,
Christian


   
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johan
(@j)
Joined: 4 years ago
Posts: 1191
 

@chris48 Hi Christian, good to hear the SX went well. Some observations and ideas:

Curcumol enhances the anti-tumor effects of metformin via suppressing epithelial-mesenchymal transition in triple-negative breast cancer.
https://atm.amegroups.com/article/view/49389/html

Interfering with Metabolic Profile of Triple-Negative Breast Cancers Using Rationally Designed Metformin Prodrugs
https://onlinelibrary.wiley.com/doi/10.1002/anie.202102266

Note that:
"type 2 diabetes was associated with a 40% increased risk of triple-negative breast cancer
when compared with women who did not have diabetes."
AND type 2 diabetes treated with metformin: there was a statistically significant 74% increased risk of developing TNBC among those treated with metformin.
https://www.esmo.org/newsroom/press-releases/metformin-may-affect-risk-of-breast-cancer-in-women-with-type-2-diabetes

IMO, METF is likely OK short-term, not long-term.

Chlorogenic acid, an essential component of Annurca apple polyphenol extract
https://www.sciencedirect.com/science/article/pii/S1936523321002850

Synergy with EGCG:
https://www.sciencedirect.com/science/article/pii/S1936523321002850

Epigallocatechin-3-Gallate (EGCG) inhibits cell proliferation and migratory behaviour of triple-negative breast cancer cells
https://pubmed.ncbi.nlm.nih.gov/23646788/

Combinatorial bioactive botanicals re-sensitize tamoxifen treatment in ER-negative breast cancer via epigenetic reactivation of ERα expression
https://www.nature.com/articles/s41598-017-09764-3

Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066124/

Nutritional combinatorial impact on the gut microbiota and plasma short-chain fatty acids levels in the prevention of mammary cancer in Her2/neu estrogen receptor-negative transgenic mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774855/

Vorinostat and indole-3-carbinol modulate microRNAs and histone deacetylase activity in subtypes of triple-negative breast cancer
https://aacrjournals.org/cancerres/article/78/13_Supplement/5800/630296/Abstract-5800-Vorinostat-and-indole-3-carbinol

Graviola: Effects of Annona muricata Extract on Triple-Negative Breast Cancer Cells Mediated Through EGFR Signaling
https://pubmed.ncbi.nlm.nih.gov/33304106/

In vitro evaluation of Annona muricata L. (Soursop) leaf methanol extracts on inhibition of tumorigenicity and metastasis of breast cancer cells
https://pubmed.ncbi.nlm.nih.gov/33048613/

Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell
https://pubmed.ncbi.nlm.nih.gov/28938245/

https://synergiesforcancertreatments.blogspot.com/

Best of luck!

 


   
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Chris48
(@chris48)
Joined: 1 year ago
Posts: 14
Topic starter  

@j This is really helpful! Thank you so much, Johan!


   
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