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TNBC / testing strategies in a NED situation

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(@j)
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Posted by: @j

Posted by: @j

Posted by: @jens

@j Hi Johan. thanks again for responding so quickly . I was interested to see what has been working with Laika. A couple of thoughts.: 

I know your father in law took Sodium Phenylbutyrate. Did he do that originally or after the mainstream treatment ? I have started Lourdes on 3g per day and am thinking of going to 

My wife (Lourdes)is having Stereotypic radiation next week and I am hoping to maximise the application. I saw some studies with  high dose Silibin increasing the effectiveness of Radiation. It was to lung cancer so I am not sure how it could corelate to TNBC.

Thanks.

 

Jens

 

 

Hi @jens and sorry to hear of the bad news. When phenylbutyrate (PB) is metabolized in the body it produces the byproducts phenylacetylglutamine and phenylacetate. My father-in-law took a product called A10 which is a mixture of phenylacetylglutamine and phenylacetylisoglutamine in a 4:1 ratio. Hence, PB can be used as an alternative to A10, although it is not as effective (as per Burzinsky).

We administered A10 (18 pils, 3 x 6 a day with each meal or vegetable juice) together with chemotherapy (CCNU). In addition we co-administered tamoxifen (40mg) and melatonin (15mg). 

I'll look into ways of enhancing RX.

 

3 grams is a good dose to start and I'd up titrate to 6 and 9 grams, in 3 divided doses. In my view, ornithine would be a good addition to PB, and maybe some Vitamin B2.

 

 

L-Ornithine and Phenylacetate/Phenylbutyrate Synergistically Produce Sustained Reduction in Ammonia and Brain Water in Cirrhotic Rats

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.22897

 


   
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 jens
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@j hi johan

 

I am not really sure what to  think anymore. That could be the reason. I think the when we went to Germany and had two treatments of the Oncolytic Virus the tumors grew at an incredible rate. I knew this was a possibility and needed something to slow the rapidly dividing cells. At the time I couldn't do IVc and IV curcumin due to the cost of the OV. She then discontinued all of my protocols due to getting neuropathy and depression unfortunately. We stopped the 90mg Lansoprazole with which was reacting with the Metformin and atorvastatin- neuropathy

But now we are concentrating on the Brain Mets and the radiation planned for next week. I have attached her current protocol for review. She is taking all the supplements well.  I am hoping for a good result. 

We have not been offered Immunotherapy only Carboplatin and Gemcitabine. I asked the Oncologist if he could reduce the chemo to 805 which he did. 

We have been having 3 weekly IVC75 mg and IV Curcuman 250 ml I combine it with oral DCA 4G

Plus now she is  taking the Sodium Phenylbutyrate as well.

I am trying to source the Tetrahydrochloride.( Ammon caps) 

Johan I know you are busy I asked Daniel but he is busy can you possible take a look at the biopsy testing  results we had done in Germany and see if you see anything that stands out. I cant get anyone to look at it. Its crazy. As I mentioned her own oncologist wont even look at it.


   
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jens
 jens
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hi Johan

 

Continuation of the last post.

Attached  is Lourdes current protocol.

I forgot to mention I had our Integrative doctor put 2g of 2DG into a isometric pump and unfortunately it dispersed in only about 8 hrs. This was the same pump Daniel recommended. If you or anyone has any suggestion on how to have the 2DG dispense metronomically please advise.

 

Thanks Johan.

 

Jens


   
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(@j)
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@jens Hi Jens, I'll study the report today. I know it's frustrating, there seems to be a disconnect between all sorts of modern diagnostic tools and technologies and the willingness and preparedness of oncologists to actually do something with the information.


   
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(@j)
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@jens 

could you give an estimate of the time she's been taking the supplements and drugs (especially the repurposed drugs e.g. fenben ). Thanks.


   
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(@j)
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@jens Hi Jens, please find my notes about the biopsy report in the attached PDF.


   
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(@j)
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Posted by: @jens

hi Johan

 

Continuation of the last post.

Attached  is Lourdes current protocol.

I forgot to mention I had our Integrative doctor put 2g of 2DG into a isometric pump and unfortunately it dispersed in only about 8 hrs. This was the same pump Daniel recommended. If you or anyone has any suggestion on how to have the 2DG dispense metronomically please advise.

 

Thanks Johan.

 

Jens

 

@jens

Suggestions:

review your protocol taking into consideration the suggestions in the PDF (Artemisinin, Luteolin, etc...)

instead of Fenbendazole try Albendazole (induces immunotherapy response by facilitating ubiquitin-mediated PD-L1 degradation & https://pubmed.ncbi.nlm.nih.gov/31781983/)

instead of Loratadine try cyproheptadine

discontinue high dose VITB1

discontinue metformin

discontinue K1 (Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481349/)

check for synergies

 


   
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(@j)
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In spite of the recommendation of the biopsy report, I'd try Tamoxifen 30 - 40mg to start and reduce it to 20mg for maintenance. Melatonin 10 to 20mg at night, around 9 PM.


   
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(@j)
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magnolol and amentoflavone for CDK6 and MMP9 inhibition.


   
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(@j)
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phenylbutyrate, consider adding L-ornithine.


   
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(@j)
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methylene blue, consider co-administration with α-lipoic acid

https://pubmed.ncbi.nlm.nih.gov/32298377/

"We propose to apply drugs used for the metabolic therapy of cancer to target the Warburg effect at different levels, on CHO cells. The use of α-lipoic acid, a pyruvate dehydrogenase activator, replenished the Krebs cycle through increased anaplerosis but resulted in mitochondrial saturation. The electron shuttle function of a second drug, methylene blue, enhanced the mitochondrial capacity. It pulled on anaplerotic pathways while reducing stress signals and resulted in a 24% increase of the maximum mAb production"


   
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(@j)
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Niclosamide


   
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(@j)
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"low doses of niclosamide and quinacrine to treat melanoma; and found a novel mechanism by which the combination application of low doses of niclosamide and quinacrine exerts an efficient anti-melanoma effect through activation of autophagy-mediated p53-dependent apoptosis. The novel strategy was verified to exert a universal anti-cancer role in other types of cancer."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048101/


   
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(@j)
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Posted by: @j

"low doses of niclosamide and quinacrine to treat melanoma; and found a novel mechanism by which the combination application of low doses of niclosamide and quinacrine exerts an efficient anti-melanoma effect through activation of autophagy-mediated p53-dependent apoptosis. The novel strategy was verified to exert a universal anti-cancer role in other types of cancer."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048101/

Or maybe Niclosamide in combination with DHArt, artemisinin, artesunate, or chloroquine is equally effective?

 


   
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(@j)
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niclosamide works well with DCA

Disturbance of the Warburg effect by dichloroacetate and niclosamide suppresses the growth of different sub-types of malignant pleural mesothelioma in vitro and in vivo

https://www.frontiersin.org/articles/10.3389/fphar.2022.1020343/full

 


   
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(@j)
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Posted by: @jens

I forgot to mention I had our Integrative doctor put 2g of 2DG into a isometric pump and unfortunately it dispersed in only about 8 hrs. This was the same pump Daniel recommended. If you or anyone has any suggestion on how to have the 2DG dispense metronomically please advise.

 

Thanks Johan.

 

Jens

@jens I have no knowledge about IV administration but it appears to me a device such as this would work?

https://www.physiciansresource.net/12545.html

 


   
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jens
 jens
(@jens)
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@j Hi Johan. She has been taking them since last april. But not continuously. Stomach issues.Sometimes she doesnt take all of them in one day. maybe 3/4ths.

jens


   
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 jens
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@j 

I will try it. 

Thanks.

 

Jens


   
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(@j)
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Posted by: @j

phenylbutyrate, consider adding L-ornithine.

"docking studies revealed putative binding sites of phenylbutyrate on PDK2 and 3 that are located on different sites compared to dichloroacetate (DCA), a previously known PDK inhibitor. Based on these findings, we showed both in cells and in mice that phenylbutyrate combined to DCA results in greater increase of PDHC activity compared to each drug alone. These results suggest that therapeutic efficacy can be enhanced by combination of drugs increasing PDHC enzyme activity.Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate"

https://pubmed.ncbi.nlm.nih.gov/25601413/

 


   
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(@j)
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Magnesium and B6


   
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(@j)
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@jens

Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/β-catenin signaling

https://pubmed.ncbi.nlm.nih.gov/27363012/


   
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(@j)
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Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer

https://www.mdpi.com/2072-6694/13/14/3437


   
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(@j)
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Posted by: @j

@jens Hi Jens, please find my notes about the biopsy report in the attached PDF.

berberine
baicalein
allicin (Allimed®)
caffeine
bloodroot
ursolic acid
Andrographis
artemisinin
luteolin
silibinin
betulinic acid (MCSformulas)

alkoxyglycerol

telmisartan
niclosamide
tamoxifen

 

 


   
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(@j)
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Posts: 2166
 

I see you've already got berberine


   
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(@j)
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Posted by: @j

Posted by: @j

@jens Hi Jens, please find my notes about the biopsy report in the attached PDF.

berberine
baicalein
allicin (Allimed®)
caffeine
bloodroot
ursolic acid
Andrographis
artemisinin
luteolin
silibinin
betulinic acid (MCSformulas)

alkoxyglycerol

telmisartan
niclosamide
tamoxifen

 

 

Synergies:

Artemisinin → Allicin
Luteolin → EGCG (which you have)
Silibinin → Baicalein
Andrographis → Berberine & Melatonin (you have both)
Ursolic acid → Curcumin (which you have)
Caffeine → Berberine & Quercetin (you have both)

 


   
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(@j)
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@jens "we found that the therapeutic efficacy of high-dose radiotherapy depends on the presence of DCs and CD8+ T cells, but not CD4+ T cells or macrophages, during or immediately after radiotherapy. "

https://journals.aai.org/jimmunol/article/189/2/558/86559/Radiotherapy-Promotes-Tumor-Specific-Effector-CD8

DHA (Dihydroartemisinin) selectively induced T-cell activation, with an increased proportion of Ki67+CD4+ T cells, CD25+CD4+ T cells, interferon (IFN)-γ-producing CD8+ T cells, Brdu+ CD8+ T cells and neutrophils, which was found to enhance cellular immunity to experimental malaria and overcome immunosuppression in mice.

https://www.nature.com/articles/s41392-022-01028-5

 

Ivermectin

"Robust infiltration of both CD4+ and CD8+ T cells was seen in ivermectin-treated tumors"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925581/​

 


   
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(@j)
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Posted by: @j

@jens "we found that the therapeutic efficacy of high-dose radiotherapy depends on the presence of DCs and CD8+ T cells, but not CD4+ T cells or macrophages, during or immediately after radiotherapy. "

https://journals.aai.org/jimmunol/article/189/2/558/86559/Radiotherapy-Promotes-Tumor-Specific-Effector-CD8

DHA (Dihydroartemisinin) selectively induced T-cell activation, with an increased proportion of Ki67+CD4+ T cells, CD25+CD4+ T cells, interferon (IFN)-γ-producing CD8+ T cells, Brdu+ CD8+ T cells and neutrophils, which was found to enhance cellular immunity to experimental malaria and overcome immunosuppression in mice.

https://www.nature.com/articles/s41392-022-01028-5

 

Ivermectin

"Robust infiltration of both CD4+ and CD8+ T cells was seen in ivermectin-treated tumors"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925581/​

 

The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies

https://www.researchgate.net/publication/338099777_The_Effects_of_AHCCR_a_Standardized_Extract_of_Cultured_Lentinura_edodes_Mycelia_on_Natural_Killer_and_T_Cells_in_Health_and_Disease_Reviews_on_Human_and_Animal_Studies

 


   
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(@j)
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jens
 jens
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@j Hi Johan.

 

I cant believe I didn't know about Methyl Blue until now. I just received it today. I will try to follow and mix properly. Hopefully in time for the radiation on Wed.

 

Thanks. Jens


   
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jens
 jens
(@jens)
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@j Thank you Johan.

 

I want respond to your emails but I have to swift thru the information. I now have combined the DCA with the Phenylbutyrate. I was speaking to a doctor in the  Dr Mark Rosenburg. He had a difficult time getting his patients to use more than 5 Grams at a time. Maybe we can overcome that slightly with the addition of DCA. I really have to study the exact mechanism of each drug. Its taking some time.

Thanks.

 

Jens


   
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