doesn't have added vitamin E
The mice in the study were getting the DHA and curcumin through their diet, so DHA and curcumin should probably best be taken in several doses throughout the day e.g. with each meal.
Fish oil LC-PUFAs do not affect blood coagulation parameters and bleeding manifestations: Analysis of 8 clinical studies with selected patient groups on omega-3-enriched medical nutrition
https://www.clinicalnutritionjournal.com/article/S0261-5614(17)30118-8/fulltext#secsectitle0010
Conclusion
These findings further support the safe consumption of n-3 LC-PUFAs, even at short-term doses up to 10 g/day of eicosapentaenoic acid + docosahexaenoic acid (EPA + DHA) or consumed for up to 52 weeks above 1.5 g/day, in selected vulnerable and sensitive populations such as subjects with gastrointestinal cancer or patients in an ICU. We found no evidence to support any concern raised with regards to the application of n-3 LC-PUFAs and the potentially increased risk for the occurrence of adverse bleeding manifestations in these selected patient populations consuming fish oil enriched medical nutrition.
@j what an awesome statement in that paper. "Hungry for fatty acids, tumor cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die." I love reading this.... it gave me a great visual to focus on. Thank you for all the math work on human equivalent dosages and the discussion of bioavailability....... imagine if there were plenty of labs and clinical trials working on how to make curcumin extremely bioavailable and tons of labs working on synergies....... but then, big pharma would lose so much business. So..... we will keep experimenting with ourselves and being grateful to synergy studiers. 😉
@j what an awesome statement in that paper. "Hungry for fatty acids, tumor cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die." I love reading this.... it gave me a great visual to focus on. Thank you for all the math work on human equivalent dosages and the discussion of bioavailability....... imagine if there were plenty of labs and clinical trials working on how to make curcumin extremely bioavailable and tons of labs working on synergies....... but then, big pharma would lose so much business. So..... we will keep experimenting with ourselves and being grateful to synergy studiers. 😉
@j Does this one have Vitamin E? I think I read not to take Vitamin E.
@rosed this one https://www.iherb.com/pr/garden-of-life-dr-formulated-dha-plus-dpa-citrus-1-000-mg-30-softgels/100979 doesn't contain vitamin E. I agree that it is best to avoid synthetic vitamin E (alpha-tocopherol) other tocopherols don't seem to be an issue. So it's important to check on the ingredients of the supplement.
California Gold Nutrition, DHA 700, contains mixed tocopherols and the label says the amount is less than 0.2% so that less than 2mg, a tiny amount of which even less are a-tocopherols. Garden of Life, Dr. Formulated DHA is the only DHA supplement without vit E I could find so far.
Carlson, Super-DHA Gems, 500 mg, 180 Soft Gels. Doesn't contain vitamin E.
@j what an awesome statement in that paper. "Hungry for fatty acids, tumor cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die." I love reading this.... it gave me a great visual to focus on.
I didn't know that Docosahexaenoic Acid (DHA) could suppress/kill cancer cells through ferroptosis. Artemisinin and Amentoflavone are also ferroptosis inducers.
Fish oil LC-PUFAs do not affect blood coagulation parameters and bleeding manifestations: Analysis of 8 clinical studies with selected patient groups on omega-3-enriched medical nutrition
https://www.clinicalnutritionjournal.com/article/S0261-5614(17)30118-8/fulltext#secsectitle0010Conclusion
These findings further support the safe consumption of n-3 LC-PUFAs, even at short-term doses up to 10 g/day of eicosapentaenoic acid + docosahexaenoic acid (EPA + DHA) or consumed for up to 52 weeks above 1.5 g/day, in selected vulnerable and sensitive populations such as subjects with gastrointestinal cancer or patients in an ICU. We found no evidence to support any concern raised with regards to the application of n-3 LC-PUFAs and the potentially increased risk for the occurrence of adverse bleeding manifestations in these selected patient populations consuming fish oil enriched medical nutrition.
>From the above, it seems possible to take 9000mg DHA with 6000mg curcumin (3:2 ratio as per study), short-term.
in divided doses, with meals (an edit option would really be useful hehe)
useful table: natural bioactive compounds as ferroptosis regulators.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700948/table/foods-10-02952-t001/?report=objectonly
Orlistat induces ferroptosis-like cell death of lung cancer cells
https://pubmed.ncbi.nlm.nih.gov/34085184/
" we found that orlistat reduced the expression of GPX4, a central ferroptosis regulator, and induced lipid peroxidation. In addition, we systemically analyzed the genome-wide gene expression changes affected by orlistat treatment using RNA-seq and identified FAF2, a molecule regulating the lipid droplet homeostasis, as a novel target of orlistat. Moreover, in a mouse xenograft model, orlistat significantly inhibited tumor growth and reduced the tumor volumes compared with vehicle control"
In sum; DHA, curcumin, artemisinin, and Orlistat induce ferroptosis in breast cancer, and substances that can inhibit ferroptosis should not be taken in parallel e.g. EGCG, Baicalein.
In sum; DHA, curcumin, artemisinin, and Orlistat induce ferroptosis in breast cancer, and substances that can inhibit ferroptosis should not be taken in parallel e.g. EGCG, Baicalein.
FER inhibitors are attached. You'll find curcumin on that list but curcumin appears to induce ferroptosis in breast cancer cells (Caused iron accumulation, disrupted GPX4-mediated redox homeostasis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700948/table/foods-10-02952-t001/?report=objectonly).
Designs for Health OmegAvail™ Ultra DHA - 60 Softgels (uses DeltaGold® tocotrienol, these
the right type of vitamin E, with anticancer properties). Expensive.
Pure encapsulations DHA Ultimate, uses natural mixed tocopherols.
Garden of Life Dr. Formulated DHA 1,000 mg (apparently doesn't include any vitamin E)
Ingredients: PureSeaOmega3™ Anchovy (Engraulis spp.) Fish Oil‚ Non-GMO PlantGel™ Softgel‚ Non-GMO Lemon Flavor‚ Non-GMO Rosemary Extract.
No artificial colors or preservatives.
Made in the USA / Non-GMO
Carlson, Super-DHA Gems, 500 mg, 180 Soft Gels. Doesn't contain vitamin E.
@rosed sorry, this product does contain vitamin E (a-tocopherol), I only looked at the ingredient list.
on top, it contains a lot of a-tocopherol, so not recommended, you'd expect they have an ingredient list with all substances, not just list "other ingredients"
In sum; DHA, curcumin, artemisinin, and Orlistat induce ferroptosis in breast cancer, and substances that can inhibit ferroptosis should not be taken in parallel e.g. EGCG, Baicalein.
FER inhibitors are attached. You'll find curcumin on that list but curcumin appears to induce ferroptosis in breast cancer cells (Caused iron accumulation, disrupted GPX4-mediated redox homeostasis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700948/table/foods-10-02952-t001/?report=objectonly).
In addition, Vitamin K (both K1 and K2) is a potent anti-ferroptosis compound https://www.nature.com/articles/s41586-022-05022-3
Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers
Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment
https://www.nature.com/articles/s41420-020-00315-w
"Our results exemplify the cytoprotective nature of autophagy invoked in HNK-treated breast cancer cells and put forth the notion that a combined strategy of autophagy inhibition with HNK would be more effective. Indeed, HNK and chloroquine (CQ) show synergistic inhibition of breast cancer cells and HNK-CQ combination treatment effectively inhibits breast tumorigenesis and metastatic progression. Tumor-dissociated cells from HNK-CQ treated tumors exhibit abrogated invasion and migration potential. Together, these results implicate that breast cancer cells undergo cytoprotective autophagy to circumvent HNK and a combined treatment with HNK and CQ can be a promising therapeutic strategy for breast cancer."
another update.
A good schedule for curcumin, EGCG, and aspirin may be:
Day 1 Curcumin Day 2 EGCG Day 3 Aspirin, Repeat
This way you also avoid issues with excessive blood thinning and it may be most synergistic if used sequentially
"Synergistic drug combinations can extend the use of poly(ADP-ribose) polymerase inhibitors (PARPi) such as Olaparib to BRCA-proficient tumors and overcome acquired or de novo drug resistance. To identify new synergistic combinations for PARPi, we screened a “micro-library” comprising a mix of commercially available drugs and DNA-binding ruthenium(II) polypyridyl complexes (RPCs) for Olaparib synergy in BRCA-proficient triple-negative breast cancer cells. This identified three hits: the natural product Curcumin and two ruthenium(II)-rhenium(I) polypyridyl metallomacrocycles"
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00322
Note that, in ovarian cancer, no Overall Survival Difference was found with PARP Inhibitors Maintenance Therapy.
https://synergiesforcancertreatments.blogspot.com/2023/05/no-overall-survival-difference-with.html
β-Glucan produced by Lentinus edodes suppresses breast cancer progression via the inhibition of macrophage M2 polarization by integrating autophagy and inflammatory signals
https://onlinelibrary.wiley.com/doi/full/10.1002/iid3.876
Natural compound found in cardamom shows promise for treating triple-negative breast cancer
"This is the first study to describe cardamonin's inhibitory effect on the expression of PD-L1, which is relevant for the treatment of triple-negative breast cancer,"
@laika Hi Laika.
Hope all is well. Unfortunately my wife now has mets to the brain. I was just wondering what you did once brain mets were diagnosed. She is scheduled for stereotypic radiation next week on 4 lesions. Did you initially do the radiation? Thanks Laika
Jens
