TNBC reoccurrence m...
 
Notifications
Clear all

TNBC reoccurrence mets to skin inoperable tumour In right breast and left lymph node involved

73 Posts
5 Users
22 Likes
2,379 Views
(@j)
Joined: 6 years ago
Posts: 2136
 

Resveratrol. Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-13-6 "Our findings suggest promotion of mammary tumor growth and metastasis by resveratrol at all concentrations tested in tumors derived from the low metastatic estrogen receptor (ER)α(-), ERβ(+) MDA-MB-231 and the highly metastatic ER(-) MDA-MB-435 cancer cell lines. Additionally, the activity of the migration/invasion regulator Rac, which we have previously shown to be regulated by resveratrol in vitro, was measured in tumors from resveratrol treated mice. Our results show a significant induction of tumoral Rac activity and a trend in increased expression of the Rac downstream effector PAK1 and other tumor promoting molecules following resveratrol treatment."


   
ReplyQuote
(@lulabelle39)
Joined: 4 years ago
Posts: 13
Topic starter  

Hi All,

I realised I haven’t checked in for a while… I’ve been on holiday and well so far living my life! I went with atezolizumab and Nab-pacitaxel.  I have some neuropathology from it and have been using turkey tail, lions mane I on and off used various supliments.

I went mostly plant based with the odd bit of halloumi from sheep now cows milk. Occasionally I had red meat as my iron was low but then normalised when I was NED. No sugar, no wheat. I now eat more things but did this for a year whilst on treatment. I intermittently fast no food evenings and no breakfast I eat at 12pm and have lots of green tea.

so the treatment melted the mets and skin where the cancer was away within 6months July 2020-Dec 2020 my PDL wasn’t high but for some reason the combination has has an amazing effect. I then had a mastectomy in March 2021 followed by a week of low dose radiation in may and went back on the immuno and chemo until September 2021. I have been off treatment and still NED I will have my scan in March as she has taken them down to 1 a year to keep radiation to a minimum so lots of praying that this continues as she seems to think I’m going to be ok which blows my mind!! I’m also aware that my diagnosis under an American onc would be a 3c rather than a 4 but whatever it may be I’m grateful and tentative! 
I use antihistamine also there have been studies on certain H1 helping Deslotatadine and lorotadine there is a pub med study which I couldn’t link but comes up as soon as you Google  it’s new but hopefully it’s true I also take baby asprin every other day and lots of green tea. I have to take antihistamine daily anyway as I have treatment induced rhinitis.

I hope that things go well for us all as they are also looking into a TN vaccine to prevent reoccurrence at the moment if you are five years clear of a Mets diagnosis you can go on the study. But I’m hoping it gets cleared and hold across the pond.

 

 


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

@lulabelle39 thanks for the update, wonderful to hear that you are doing so well!


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

@jens A few more observations:

 

Magnesium: I didn't see mg on your supplement plan and believe it would be a good addition.

Bicalutamide (synergistic with curcumin in TNBC)
https://journals.lww.com/anti-cancerdrugs/Abstract/2020/04000/Combination_treatment_of_bicalutamide_and_curcumin.6.aspx
"Combination treatment of curcumin and bicalutamide has a robust increase in apoptosis. Furthermore, the combination treatment suppressed the growth of AR+ triple-negative breast cancer cells more effectively than with the single drug alone. "

Quercetin:
Dose-dependent benefits of quercetin on tumorigenesis in the C3(1)/SV40Tag transgenic mouse model of breast cancer.
"Results showed an inverted ‘U’ dose-dependent effect of dietary quercetin on tumor number and volume; at sacrifice the moderate dose was most efficacious and reduced tumor number 20% and tumor volume 78% compared to control mice (C3-Con: 9.0 ± 0.9; C3-0.2%: 7.3 ± 0.9) and (C3-Con: 2061.8 ± 977.0 mm3; and C3-0.2%: 462.9 ± 75.9 mm3). Tumor volume at sacrifice was also reduced by the moderate dose compared to the high and low doses (C3-2%: 1163.2 ± 305.9 mm3; C3-0.02%: 1401.5 ± 555.6 mm3), as was tumor number (C3-2%: 10.7 ± 1.3 mm3; C3-0.02%: 8.1 ± 1.1 mm3). Gene expression microarray analysis performed on mammary glands from C3-Con and C3-0.2% mice determined that 31 genes were down-regulated and 9 genes were up-regulated more than 2-fold (P < 0.05) by quercetin treatment."
1311 mg/day to replicate the moderate dose.

Diet: Diet impacts triple-negative breast cancer growth, metastatic potential, chemotherapy responsiveness, and doxorubicin-mediated cardiac dysfunction
https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.15192


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

combination of dichloroacetate, omeprazole (plus tamoxifen), and ivermectin.

https://www.cureus.com/articles/83821-synergistic-anti-tumor-effect-of-dichloroacetate-and-ivermectin#!/

 

Case Presentation
Here, we show three cases successfully treated with a full or partial combination of dichloroacetate, omeprazole (plus tamoxifen), and ivermectin.

Case 1
A 69-year-old female was diagnosed with invasive breast cancer in October 2015. She underwent left breast partial mastectomy, but bone metastases and pleural dissemination appeared (Figure 1). She responded to chemo-endocrine therapy, but it soon became less effective, and intolerable side effects appeared. We gave up conventional therapy and started treatment with dichloroacetate, omeprazole, and tamoxifen from October 2021: weekly use of three tablets of 333 mg dichloroacetate per day (on Day 1), three tablets of 40 mg omeprazole per day (on Day 1), along with a tablet of 20 mg tamoxifen every day. This relieved her symptoms (bone pain, shortness of breath, and general fatigue) instantly but not completely. Hence, we added a tablet of 12 mg ivermectin per day (on Day 1), which stabilized pleural effusion and induced tumor marker reduction (CEA or carcinoembryonic antigen), which went down from 12.9 to 7.3, and cancer antigen 15-3 (CA15-3), which went down from 302.3 to 229.4 in three months).


   
Chris48 reacted
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Acetazolamide, especially in combination with rapamycin, is yet another option to consider.

A Biomimetic Drug Delivery System Targeting Tumor Hypoxia in Triple-Negative Breast Cancers

https://www.mdpi.com/2076-3417/10/3/1075

In combination with rapamycin:

https://encyclopedia.pub/entry/21938

 


   
Chris48 reacted
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Posted by: @jens

@j Hi Johan

As always thanks for all your hard work. 

This is a update for my wife Lourdes with TNBC with mets to the lungs. We are concentrating on the mitochondria strategy. In the meantime we started with an intratumoral Oncolytic Virus- they are using a combination of three different viruses. Next wed will by her second dose. Its very expensive for us and I am not sure how many months we can continue for. They will be combining it with an PDL shortly. We are concentrating on the immune system and gut bacteria to support the virus therapy. Please see the list of supplements we are using at the moment. I am concerned the cancer will get aggressive like it did for Daniels wife and many others. As much as possible we are trying to concentrate on the immune system as well as the gut microbe. I am worried we are not doing anything that's potent enough to kill the fast dividing cells. Only IV C and just started 2DG metronomically. I have 3  questions I am hoping you or anyone else might help with. Please look at the attached current list she is taking. I also just received DCA. We used it previously for a few months and did not notice any significant results.

1. She just started taking Ivermectin-Using .5mg /1kg

a) Can we combine it with hydroxychloroquine? Would that be prudent.

b) With mets to the lungs i am thinking of possibly using ivermectin in a nebulizer form. I am not in the medical field so I am hesitant in formulating an effective delivery method. I just want to do something prior to her having her breathing effected 

2. I was reading all the literature about  using silver nano particles. Because of the copper depletion side effect i think it might be useful addition to our fight. We cannot afford Tetrathiomolybdate. Can I implement  the silver with immunotherapy without risking damage to  the gut microbe. I know to use probiotics right after a few hours after use but is that enough not to compromise the immunotherapy.

3 My wife started experiencing  really awful neuropathy( mostly numbness) about 2 months before the Virus treatment. Both in the lower feet and end of her fingers. I had stopped DCA for over 2 months so I dont think thats the cause. I have examined the drug and supplement combinations she is taking and I cannot find the cause.  She was taking OLARPERIB but had stopped in October after progression. I dont think thats the cause. Please see if you can see what it could be.

Thanks.

Jens

 

 

Hi Jens, I've attached a note with Lourdes' current oral protocol organized according to anticancer synergies.

 


   
Chris48 reacted
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

there's a formatting issue in that attachement, there should be arrows instead of →


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

@jens same note but I changed the arrows for a + sign.


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136

   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

@jens 

Study on the Correlation Between B Vitamins and Breast Cancer

https://assets.researchsquare.com/files/rs-961568/v1/ad71c4e2-fff2-42b6-8b6c-a6343d38975a.pdf?c=1634653775

"Although it is known that B vitamins are used as coenzymes to participate in the methylation cycle, DNA, RNA, protein and phospholipid synthesis in the body.
When the abnormal level of B vitamins in human serum causes any of these metabolic pathways to be interrupted, it may interfere with DNA replication, repair,
and regulation of gene expression, and ultimately promote cell cancer[36–37]. However, there are currently few studies on the relationship between B vitamins
and breast cancer, and the role of B vitamins in the occurrence and development of breast cancer is still inconclusive. In our research, we measured the B
vitamins that play a major role in the human body and found that VitB2, VitB6, VitB7, and VitB12 have no significant differences in healthy controls, patients
with breast benign diseases, and breast cancer patients, which also suggests that VitB2, VitB6, VitB7, VitB12 have no significant correlation with breast cancer
risk. Similarly, Zeng J et al. conducted a prospective study and meta-analysis of one carbon unit and breast cancer risk and also proposed that there is no
significant association between VitB12 and breast cancer[37]. Related research by Arthur RS et al. also proposed that there is no significant association
between group B vitamins and breast cancer[53]. This is consistent with some of our research results.
In addition, we also found that the expression levels of VitB1, VitB3, VitB5, and VitB9 in the three groups were statistically significant (P<0.001). After further
analysis of VitB1, VitB3, and VitB5, it was found that the serum levels of VitB1 and VitB5 in breast cancer patients and patients with benign breast diseases
were higher than those in healthy controls, while the expression level of VitB3 in breast cancer patients was lower than the other two groups. The results
suggest that the levels of VitB1, VitB3, and VitB5 may be related to the occurrence and development of breast cancer, and provide certain evidence for the
further exploration of vitamins in the etiology of breast cancer. It also suggests to a certain extent that monitoring the levels of VitB1, VitB3, and VitB5 in the
body and being alert to changes in their levels is helpful for early detection and early diagnosis of breast cancer."


   
Chris48 reacted
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

@jens

One more observation, regarding phenylbutyrate.

Dr. Burzinsky's formulations often uses socalled antineoplastions and phenylbutyrate with vitamin b2 and a few aminoacids:

Check out this patent: https://patents.google.com/patent/US7427619B2/en

Still another alternative embodiment of the present invention (AVF) comprises 0.01-10 wt % riboflavin, 1-15 wt % arginine, and 1-15 wt % ornithine, 1-15 wt % alanine, 1-15 wt % glycine, 1-15 wt % serine, 1-15 wt % threonine 1-15 wt % valine, and 25-75 wt % sodium phenylbutyrate. Sodium phenylbutyrate converts to phenylacetylglutamine (PG) in the liver and is a pro drug of phenylacetylglutamine. A typical AVF formulation is shown below.
 
For my father-in-law we used a formulation called Aminocare A10, which back then included antineoplastons:
 
He took 18 capsules a day of that product, for several months. Since the product had 10mg of B2 per serving he was getting about 90mg of B2 a day as supplemental B2. 
 
Hope this helps.

   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Posted by: @jens

@j Hi Johan

Please look at the attached current list she is taking. I also just received DCA. We used it previously for a few months and did not notice any significant results. 

@jens Here's a summary of my notes regarding your lists of drugs and supplements.

Cimetidine.

in combination with Metformin can cause lactic acidosis.

Ivermectin.

The relative safety of IVM use comes from the fact we don’t have any glutamate-gated ion channels outside of the brain and spinal cord, and only a low dose is taken just one time for its intended use. If and when IVM crosses the BBB, IVM will bind to the glutamate-gated ion channels in the brain. IMO a nebulizer with IVM delivery method increases the risk of penetrating the BBB.

I don't think there's a problem combininng oral IVM with hydroxychloroquine, but you'll have to verify for interactions with all the other drugs she's taking.

Aspirin.

I don't think 81mg can produce an anti-cancer effect, this is a dose possibly for cancer prevention but not for active cancer. From what I've read this should be at least 600mg, and probably several grams (divided doses and dissolved in water to reduce stomach upset).

Loratadine.

Mice injected with loratadine had tumor weights 150 percent to 390 percent larger than the control mice.
https://pubmed.ncbi.nlm.nih.gov/7909571/

I believe the evidence supporting Loratadine comes primarily from a meta analysis done in Sweden. The researchers said that they had started studies to confirm these findings. I can't find any news on this.

Quercetin.

Dose-dependent benefits of quercetin on tumorigenesis in the C3(1)/SV40Tag transgenic mouse model of breast cancer.
"Results showed an inverted ‘U’ dose-dependent effect of dietary quercetin on tumor number and volume; at sacrifice the moderate dose was most efficacious and reduced tumor number 20% and tumor volume 78% compared to control mice (C3-Con: 9.0 ± 0.9; C3-0.2%: 7.3 ± 0.9) and (C3-Con: 2061.8 ± 977.0 mm3; and C3-0.2%: 462.9 ± 75.9 mm3). Tumor volume at sacrifice was also reduced by the moderate dose compared to the high and low doses (C3-2%: 1163.2 ± 305.9 mm3; C3-0.02%: 1401.5 ± 555.6 mm3), as was tumor number (C3-2%: 10.7 ± 1.3 mm3; C3-0.02%: 8.1 ± 1.1 mm3). Gene expression microarray analysis performed on mammary glands from C3-Con and C3-0.2% mice determined that 31 genes were down-regulated and 9 genes were up-regulated more than 2-fold (P < 0.05) by quercetin treatment."
1311 mg/day to replicate the moderate dose.

Dichloroacetate.

combination of dichloroacetate, omeprazole (plus tamoxifen), and ivermectin.

https://www.cureus.com/articles/83821-synergistic-anti-tumor-effect-of-dichloroacetate-and-ivermectin#!/

Resveratrol.

Conflicting findings, many studies show an inhibitory effect on cancer but in my opinion, there's reason for caution about its use in hormonal cancers.

Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-13-6 "Our findings suggest promotion of mammary tumor growth and metastasis by resveratrol at all concentrations tested in tumors derived from the low metastatic estrogen receptor (ER)α(-), ERβ(+) MDA-MB-231 and the highly metastatic ER(-) MDA-MB-435 cancer cell lines. Additionally, the activity of the migration/invasion regulator Rac, which we have previously shown to be regulated by resveratrol in vitro, was measured in tumors from resveratrol treated mice. Our results show a significant induction of tumoral Rac activity and a trend in increased expression of the Rac downstream effector PAK1 and other tumor promoting molecules following resveratrol treatment."

Benfotiamine.

Study on the Correlation Between B Vitamins and Breast Cancer

https://assets.researchsquare.com/files/rs-961568/v1/ad71c4e2-fff2-42b6-8b6c-a6343d38975a.pdf?c=1634653775

"it was found that the serum levels of VitB1 and VitB5 in breast cancer patients ...
were higher than those in healthy controls, while the expression level of VitB3 in breast cancer patients was lower than the other two groups."

Considering the DV for B1 is about 1,5mg a day, and benfotiamine boosts B1 absorption 3 to 5X, 250mg 3 times a day is a very high dose. I assume the purpose for the high dose is to replicate the findings of this in vitro study:
https://www.mdpi.com/1420-3049/23/6/1464. ? Or is it part of a protocol with dichloroacetate?
Do you know of any in vivo study that confirms the in vitro findings?

Melatonin

Also a very high dose. Is there in vivo evidence to support such high doses?

Phenylbutyrate.

In his formulations, Dr. Burzynski combines antineoplastons or phenylbutyrate, with vitamin B2 and various amino acids.

For my father-in-law we used a formulation called Aminocare A10, which back then included antineoplastons:
https://synergiesforcancertreatments.blogspot.com/p/aminocare.html

He took 18 capsules a day of that product which amounts to 90mg of B2 a day as supplemental B2.

Suggestions:

Magnesium

Artemisinin

Acetazolamide + rapamycin.

A Biomimetic Drug Delivery System Targeting Tumor Hypoxia in Triple-Negative Breast Cancers

https://www.mdpi.com/2076-3417/10/3/1075

In combination with rapamycin:

https://encyclopedia.pub/entry/21938

 


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

I've mentioned the synergy of Emodin with Berberine recently, in addition, Thymoquinone and Emodin inhibit breast cancer proliferation synergistically while enhancing cytotoxicity {ref}.

More synergy: Emodin and curcumin (on your list). {ref}


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

"The inhibition of respiratory chain by metformin causes a shift from aerobic to anaerobic metabolism which produces lactic acid as the end product."

https://www.openaccessjournals.com/articles/metformincarbonic-anhydrase-interaction-facilitate-lactate-accumulation-in-type-2-diabetes-12149.html


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

"To further test the effect of nutritional environment/food starvation on anticancer activity of metformin, the authors injected 1 × 106 A498 cells into nude mice, which was supposed to mimic an in vivo form of renal cancer, and restricted their dietary intake to resemble the effect of glucose deprivation. Food starvation alone slowed, but did not suppress, tumor growth. However, the study suggested that under glucose starvation, metformin treatment did not suppress the tumor growth, but in fact increased its volume.

In addition, the authors tested the expression of proliferation marker, Ki-67, and reported that metformin treatment suppressed the expression of Ki-67 under normal conditions, but induced its expression under glucose deprivation. Additionally, the in vivo analysis of Ki-67 revealed that metformin treatment promoted cellular proliferation in food-starved nude mice and that metformin treatment may increase renal cancer cell proliferation under glucose deprivation. In conclusion, they suggested that the antiproliferative effects of metformin in cancer cells are highly dependent on the glucose concentration in the extracellular environment."

 


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

People who are on ketogenic diets and taking metformin in the belief that it will stop or reduce cancer are probably increasing their tumors. In my opinion, Jane Mclelland & co. are actually harming people with this keto + metformin nonsense.


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Posted by: @jens

@j Hi Johan

 

3 My wife started experiencing  really awful neuropathy( mostly numbness) about 2 months before the Virus treatment. Both in the lower feet and end of her fingers. I had stopped DCA for over 2 months so I dont think thats the cause. I have examined the drug and supplement combinations she is taking and I cannot find the cause.  She was taking OLARPERIB but had stopped in October after progression. I dont think thats the cause. Please see if you can see what it could be.

Thanks.

Jens

 

About the neuropathy, maybe lansoprazole and/or cimetidine  https://pubmed.ncbi.nlm.nih.gov/3010423/

Also, Metformin is linked to neuropathy:

https://www.nature.com/articles/s41598-021-81631-8#:~:text=Abstract,diabetic%20peripheral%20neuropathy%20(DPN).

My guess is the combination of metformin and cimetidine and maybe lansoprazole is causing the  peripheral neuropathy.

 

 


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Neuropathy is a symptom of lactic acidosis, and we know metformin can produce elevated lactic acid and cimetidine can make it even worse. 


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Drug–nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3)

https://www.sciencedirect.com/science/article/pii/S0002916522009789?via%3Dihub

"Our high-throughput screen of 1360 compounds, including many clinically used drugs, identified 146 potential inhibitors at 200 μM. Inhibition kinetics were determined for 28 drugs with half-maximal inhibitory concentration (IC50) values ranging from 1.03 μM to >1 mM. Several oral drugs, including metformin, were predicted to have intestinal concentrations that may result in ThTR-2–mediated drug–nutrient interactions."

If Metformin blocks b1 transporters how do you calculate the dose requirement for B1, for its intended purpose?

"Vitamin B1 supplementation has a duality of effects on cancer cell survival and proliferation.
At low to moderate doses, thiamine has been shown to support cancer cell proliferation.
Comín-Anduix et al. found an increase in tumor proliferation at values from 12.5* to 75 times*
the recommended daily allowance (RDA) in an Ehrlich ascites tumor model [19]. This stimulation
of cell proliferation may be supported by alterations in expression and utilization of
thiamine-dependent enzymes during malignancy. In particular, the thiamine-dependent enzyme
transketolase has been shown to be up-regulated in a variety of cancers including colon,
urothelial, breast, ovarian, and gastric and is essential for generation of nucleotide
precursors to sustain rapid proliferation "

According to these findings, the > 15mg and < 90mg range is best avoided in cancer. If you take metformin with a high vitamin B1 dose how can you know you're not in that range? In my opinion, only < 15mg vitB1 dose would be safe when taken with metformin.?

 


   
ReplyQuote
jens
 jens
(@jens)
Joined: 2 years ago
Posts: 91
 

@j Hi Johan.

She stopped the cimetidine because of food not digesting and was only using Lansoprazole.

Thanks.

jens


   
ReplyQuote
jens
 jens
(@jens)
Joined: 2 years ago
Posts: 91
 

@j Hi Johan.

 

Sorry for the late response. Thank you for all your help Johan. We were in Germany for my Lourdes second Ov Treatment and just came back.

I do think you are correct it could be the Metformin and the Lansoprazol that could be the course of the neuropathy. I also stopped the Atorvastatin. I saw one of the rare side effects was neuropathy. I am just concerned with what I can replace it with for the same mechanisms. I have switched the Metformin to all berberine. I am wondering if I should keep the Atorvastatin and try and see what happens with the removing the Metformin. I think we should keep the Lansoprazole too but maybe only use it when given IVC, DCA,or 2DG.

Since we have come back Lourdes tumors i believe have grown from the OV treatment. She is in a lot of pain due to the lung mets. I have DCA in oral form- and (Vitamin C in Powder which I can make into IV) and we have the pumps for metromonic delivery of 2DG but not 2DG yet. No Salicinium. Since we are not doing chemo with the local NHS I don't have any access. Not really sure in what direction to go since the IV C and DCA was not doing much to reduce the tumors.

 

Thanks Johan. I will keep everyone updated. 

jens

 


   
ReplyQuote
jens
 jens
(@jens)
Joined: 2 years ago
Posts: 91
 

@johan

Hi Johan

Considering the DV for B1 is about 1,5mg a day, and benfotiamine boosts B1 absorption 3 to 5X, 250mg 3 times a day is a very high dose. I assume the purpose for the high dose is to replicate the findings of this in vitro study:
https://www.mdpi.com/1420-3049/23/6/1464.  ? Or is it part of a protocol with dichloroacetate?

I was using the B1 to enhance the DCA

The Melatonin at a high dose is a  protocol from the Riordan Clinic.

https://riordanclinic.org/wp-content/uploads/2019/03/3-3-Shallenberger-High-Dose-Melatonin-Therapy-An-Ideal-Adjuvant.pdf

Thanks.

Jens


   
johan reacted
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Posted by: @jens

@j Hi Johan.

 

I am wondering if I should keep the Atorvastatin and try and see what happens with the removing the Metformin. 

Hi @jens

Statins combined with niacin reduce the risk of peripheral neuropathy

https://www.spandidos-publications.com/10.3892/ijfn.2020.3

Niacin comes in flush and no-flush versions, I'd try the no-flush niacin in combination with atorvastatin.

 


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Posted by: @j

Posted by: @jens

@j Hi Johan.

 

I am wondering if I should keep the Atorvastatin and try and see what happens with the removing the Metformin. 

Hi @jens

Statins combined with niacin reduce the risk of peripheral neuropathy

https://www.spandidos-publications.com/10.3892/ijfn.2020.3

Niacin comes in flush and no-flush versions, I'd try the no-flush niacin in combination with atorvastatin.

 

I was listening to Abram Hoffer, MD PhD (Niacin, The real story) and he mentioned niacin in high doses can have a sedative effect, so it may also help to alleviate pain. Niacin is a very interesting molecule, being an NAD+ precursor. This audiobook is available for free on audible.com. 

 


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Posted by: @j

Posted by: @j

Posted by: @jens

@j Hi Johan.

 

I am wondering if I should keep the Atorvastatin and try and see what happens with the removing the Metformin. 

Hi @jens

Statins combined with niacin reduce the risk of peripheral neuropathy

https://www.spandidos-publications.com/10.3892/ijfn.2020.3

Niacin comes in flush and no-flush versions, I'd try the no-flush niacin in combination with atorvastatin.

 

I was listening to Abram Hoffer, MD PhD (Niacin, The real story) and he mentioned niacin in high doses can have a sedative effect, so it may also help to alleviate pain. Niacin is a very interesting molecule, being an NAD+ precursor. This audiobook is available for free on audible.com. 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582128/

"Specific enhancement of mitochondrial complex I activity inhibited tumor growth and metastasis through regulation of the tumor cell NAD+/NADH redox balance, mTORC1 activity, and autophagy. Conversely, nonlethal reduction of NAD+ levels by interfering with nicotinamide phosphoribosyltransferase expression rendered tumor cells more aggressive and increased metastasis. The results translate into a new therapeutic strategy: enhancement of the NAD+/NADH balance through treatment with NAD+ precursors (nicotinamide/niacin) inhibited metastasis in xenograft models, increased animal survival, and strongly interfered with oncogene-driven breast cancer progression in the MMTV-PyMT mouse model."

Metformin will decrease mitochondrial complex I activity

"To test this hypothesis, we used the aggressive metastatic, triple-negative breast cancer cell model 4T1. In vitro, addition of NAM significantly enhanced NAD+/NADH ratios in 4T1 cells (Figure (Figure7A),7A), indicative of a response to NAD+ precursor treatment. To analyze therapeutic effects of NAM treatment in the animal model, F-luc–tagged 4T1 cells were injected in the fourth mammary fat pad of immunocompetent BALB/c mice, and tumors were removed surgically when they reached a volume of 300 mm3. At the time of surgical removal, mice were randomized into control (untreated water) and NAD+ precursor treatment (1% NAM in drinking water for the remainder of the experiment) groups (n = 8 each), and tumor weights were measured (Figure (Figure7B).7B). At the time of surgery and before NAM treatment, 1 animal in each group had spontaneous metastasis in the lungs, as measured by noninvasive bioluminescence imaging. At 1 week after tumor removal, 7 of 8 control mice and 5 of 8 NAM-treated mice had detectable metastases. After 2 weeks, 8 of 8 controls and 6 of 8 NAM-treated mice showed metastasis. At the end of the experiment (day 70 after surgery), 1 animal in the treatment group still had no detectable recurrence. Importantly, NAM (nicotinamide) treatment starting after primary tumor surgery significantly increased animal survival in this model of highly aggressive metastatic breast cancer "

 

 


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

@jens in response to @chris46 I previously posted:

"type 2 diabetes was associated with a 40% increased risk of triple-negative breast cancer
when compared with women who did not have diabetes."
AND type 2 diabetes treated with metformin: there was a statistically significant 74% increased risk of developing TNBC among those treated with metformin.
https://www.esmo.org/newsroom/press-releases/metformin-may-affect-risk-of-breast-cancer-in-women-with-type-2-diabetes "

In my view, the evidence presented in this study, combined with the study I posted above, warrants extra precaution when using metformin to treat Triple Negative Breast Cancer.

The study Chris included in his file is an in vitro study, which should be given less importance compared to in vivo studies.


   
Chris48 reacted
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Posted by: @j

@jens in response to @chris46 I previously posted:

"type 2 diabetes was associated with a 40% increased risk of triple-negative breast cancer
when compared with women who did not have diabetes."
AND type 2 diabetes treated with metformin: there was a statistically significant 74% increased risk of developing TNBC among those treated with metformin.
https://www.esmo.org/newsroom/press-releases/metformin-may-affect-risk-of-breast-cancer-in-women-with-type-2-diabetes "

In my view, the evidence presented in this study, combined with the study I posted above, warrants extra precaution when using metformin to treat Triple Negative Breast Cancer.

The study Chris included in his file is an in vitro study, which should be given less importance compared to in vivo studies.

I meant @chris48. 😊 

 


   
Chris48 reacted
ReplyQuote
(@chris48)
Joined: 2 years ago
Posts: 45
 

@j Thank you so much for pointing that out! This is of course worrying. I will ask the doctor from the Care Oncology Clinic about it. But if there is no great explanation why these bad study results would only be valid for diabetics, I think we should replace it. Would you consider Berberine as less risky in that regard?


   
ReplyQuote
(@j)
Joined: 6 years ago
Posts: 2136
 

Posted by: @chris48

@j Thank you so much for pointing that out! This is of course worrying. I will ask the doctor from the Care Oncology Clinic about it. But if there is no great explanation why these bad study results would only be valid for diabetics, I think we should replace it. Would you consider Berberine as less risky in that regard?

I would indeed, Chris. Especially if used in synergistic combinations shown to be efficacious in TNBC, such as with emodin. But clearly, it should be used with great caution.

Note that it's not only the study with diabetics, have you seen this study? (also posted above) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582128/  

"Specific enhancement of mitochondrial complex I activity inhibited tumor growth and metastasis through regulation of the tumor cell NAD+/NADH redox balance, mTORC1 activity, and autophagy. Conversely, nonlethal reduction of NAD+ levels by interfering with nicotinamide phosphoribosyltransferase expression rendered tumor cells more aggressive and increased metastasis. The results translate into a new therapeutic strategy: enhancement of the NAD+/NADH balance through treatment with NAD+ precursors (nicotinamide/niacin) inhibited metastasis in xenograft models, increased animal survival, and strongly interfered with oncogene-driven breast cancer progression in the MMTV-PyMT mouse model."

Metformin does the opposite. More reason for caution. 

I don't think you can expect an unbiased response from the doctors at that clinic, for obvious reasons. 

 


   
Chris48 reacted
ReplyQuote
Page 2 / 3
Share: