LDN (three nights on/two off)  

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luce
 luce
(@luce)
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Joined: 2 years ago
Posts: 3
19/02/2019 7:03 am  

I used to take LDN for primary breast cancer briefly but then stopped when I came across this info on your site: 

 

 

 

 

 

 

 

 

“These results have translational relevance, demonstrating that TP53 mutant breast tumor growth can be suppressed by pharmacologic TLR4 inhibition, whereas TLR4 inhibitors may in fact promote growth of TP53 wild-type tumors. Furthermore, using data generated by The Cancer Genome Atlas consortium, we demonstrate that the effect of TP53 mutational status on TLR4 activity may extend to ovarian, colon, and lung cancers, among others, suggesting that the viability of TLR4 as a therapeutic target depends on TP53 status in many different tumor types.” http://www.pnas.org/content/112/25/E3216.full.pdf

 

I expect TP53 status can be checked with chemosensitivity test that should be accessible to many.

 

Also, if the tumor (in this case of breast) will not respond to chemo it is likly that is of wild-type: “We reported that TP53 mutated non inflammatory locally advanced breast carcinomas had a high rate of complete pathological response to dose-dense doxorubicin-cyclophosphamide chemotherapy, while TP53 wild-type (WT) tumors never achieved complete response.”

 

https://www.ncbi.nlm.nih.gov/pubmed/24074787

 

This means to me that if the patient used chemo and did not achieved remission there is a good chance that LDN will even promote tumor growth, at least in case of breast cancer. If that is the case, we could try TLR4 agonists such as Immunomax (see one of may previous posts on this vaccine) instead of TLR4 antagonists like LDN." 

Are you still standing behind this? I am thinking of adding LDN to my repurposed drugs regimen. I asked the LDN trust and several FB groups about the possibility of LDn feling bc that you raised and never got a satisfactory reply. I am very advanced metastatic now, with no room for error. I would hope for NK activation from LDN, and also for its prosocial and antidepressant effect. Thanks for clarifying or updating or explaining further! Sincerely, Luce


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Daniel
(@daniel)
New Member Admin
Joined: 4 years ago
Posts: 284
20/02/2019 11:08 pm  

Dear Luce,

Thank you for your comment. That was the connection I've made based on various pieces of science. But science is not always right. Actually there is some conflicting science on the role of TLR4. Nevertheless, based on this recent paper, I would tend to use it  http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=24178&path[]=75994

Kind regards,
Daniel


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luce
 luce
(@luce)
New Member
Joined: 2 years ago
Posts: 3
20/02/2019 11:11 pm  

Thanks! I am interested in using it again, partly due to its pro-social effect (terminal disease and estrogen deprivation have turned me from an introvert into a total hermit). 

 


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Daniel
(@daniel)
New Member Admin
Joined: 4 years ago
Posts: 284
21/02/2019 1:06 am  

You are welcome. Propranolol is also a good one for social anxiety and has anticancer effects https://www.cancertreatmentsresearch.com/propranolol-hexokinase-2-inhibiton-a-similar-anticancer-mechanism-as-that-of-3-bromopyruvate-3bp/

But check if that is suitable with the blood pressure and heart rate.


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luce
 luce
(@luce)
New Member
Joined: 2 years ago
Posts: 3
21/02/2019 1:12 am  

thanks! i used to be on propranolol as part of an immunioherapy protocol that failed but i have cancer in my pericardium,  low blood pressure, raynaulds,... so not the ideal drug for me.

 


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