Hello everyone.

I've been wondering what may be the best combination of drugs, supplements, diet and lifestyle for a close relative of mine that has estrogen positive breast cancer with numerous metastasis to lung, liver, lymp nodes and pleura. Tumor markers have increased by a bit, but not too much yet. Only symptoms right now are constant coughing and a pleural effusion. She was stable for about 3 years with few symptoms until it was recently discovered that the cancer has metastisized to her liver as well. The doctors are unfortunately mostly useless, while the person in question is very reluctant about taking everything I'm giving her. I recently convinced her to get her cholesterol tested, and it showed slightly elevated LDL but very high triglycerides and low HDL. The good news is that in 2 weeks of treatment with the drugs, supplements and diet her CRP went down by half. Her tumor markers however have increased more than they ever have before, although I've read that treatment can initially give a false positive or false negative.

Currently, her doctors are giving her:
10 mg Tamoxifen 2x day
10 mg Everolimus 1x day

Unlike the doctors however, I'm not interested in slowing down her eventual demise. What I'm interested in is complete remission, or at the very least some progress in the right direction. Currently I'm giving her (I would give more but she is very resistant to taking everything):

Drugs:
500 mg Metformin 2x day
75 mg Dipyridamole 3x day
100 mg Aspirin 1x day
100 mg Mebendazole 1x day
5 mg Melatonin 1x day

Supplements:
HCA Garcinia Cambogia 500 mg 2x day
Berberine 250 mg 2x day
Citrus Bergamot 500 mg 2x day
Honokiol 260 mg 2x day
Sulfurophane 50 mg 2x day
Feverfew 380 mg 2x day
Ursolic Acid 250 mg 2x day
Vitamin D3 10000 IU day
DHA/EPA combined 2000 mg day

Supplements I've removed:
Curcumin (I've read that it reduces absorption of Tamoxifen and Everolimus)
Quercetin (I've read that it reduces absorption of Tamoxifen and Everolimus)
Bromelain (I've read that it reduces absorption of Tamoxifen and Everolimus)
Piperine (unsure whether it boosts or lowers absorption)
Milk Thistle (can have an estrogenic effect)

Drugs that I might add or increase dosage:
800 mg Metformin 2x day
40 mg Propranolol 1x day
Doxycycline (not sure about dosage yet)
Azithromycin (not sure about dosage yet)
Statin (Pitavastatin, very unlikely right now but might be an option if she changes her mind, could use some recommendations for cholesterol lowering supplements for now)
Hydroxychloroquine (not sure about dosage yet)
IV Vitamin C (not sure how I'll administer this as the doctors obviously won't)

Supplements that I might add or increase dosage:
Berberine 500 mg 2x day
Tocotrienols (not sure about dosage yet)
Magnesium (not sure what type and dosage yet)

Diet is "mostly" ketogenic, at least as far as I'm aware, although they generally don't like the food they are eating and want to eat carbohydrate rich foods instead. Black seed oil, coconut oil, olive oil, fish oil, Sea Buckthorn oil, fatty fish, avocados, some limited dairy products and nuts/seeds are the fats she mostly consumes. Lots of vegetables, including broccoli and cabbage. Growing my own broccoli sprouts would be a better alternative to broccoli because of the high Sulfurophane content. I am worried about the cholesterol and the ability of cancer to use fats for fuel even on a ketogenic diet. I'm also not 100% sure how much protein she is consuming as that could also fuel the cancer.

She is under a lot of stress, so I am very much considering adding Propranolol as soon possible.

I've probably left out a few things, but please let me know what you think I could improve. I've been researching cancer for a few years now, and while it is great to finally get the opportunity to test everything out myself, it is quite unfortunate that it has to be under these circumstances.