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What to take/stop during Chemo days?

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CORSARO1
(@corsaro1)
Joined: 11 months ago
Posts: 3
Topic starter  

Hi all,

I'm Emanuele and I have a high grade glioma. At the moment I'm doing Temozolomide 5 days a month plus COC Protocol and various supplements (curcumine, resveratrol, boswellia, EGCG, vitamin D and melatonin).

I'm quite confused about what tho take and what to stop during these 5 chemo days, as I have been reading that antioxidants, like most of the stuff I'm taking, are actually an obstacle to the oxidative action of temozolomide, but on other articles are saying that curcumin and resveratrol together are going to prolong the time of chemo effectiveness inside the cancer cell. 

I also recently bought from MSC formulas Honokiol and the Glutamine Inhibifour and would like to know if to stop these or not during the chemo days and when would be more effective to take? Dosage?

Daniel's approach about stopping certain supplements before chemo makes total sense to me and it is something I want to implement. 

 

Many thanks


   
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johan
(@j)
Joined: 4 years ago
Posts: 1190
 
Posted by: @corsaro1

Hi all,

I'm Emanuele and I have a high grade glioma. At the moment I'm doing Temozolomide 5 days a month plus COC Protocol and various supplements (curcumine, resveratrol, boswellia, EGCG, vitamin D and melatonin).

I'm quite confused about what tho take and what to stop during these 5 chemo days, as I have been reading that antioxidants, like most of the stuff I'm taking, are actually an obstacle to the oxidative action of temozolomide, but on other articles are saying that curcumin and resveratrol together are going to prolong the time of chemo effectiveness inside the cancer cell. 

I also recently bought from MSC formulas Honokiol and the Glutamine Inhibifour and would like to know if to stop these or not during the chemo days and when would be more effective to take? Dosage?

Daniel's approach about stopping certain supplements before chemo makes total sense to me and it is something I want to implement. 

 

Many thanks

Hi Emanuele, Honokiol, and Magnolol are definitely worth trying in high-grade gliomas. 

I have posted a case report on a recovery from glioblastoma and included possible alternative and adjacent therapies and supplements. 

https://synergiesforcancertreatments.blogspot.com/p/17-year-glioblastoma-survivor.html


   
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CORSARO1
(@corsaro1)
Joined: 11 months ago
Posts: 3
Topic starter  

@j Hi Johan,

Thank you for your prompt response, I know that Honokiol is a very effective product, do you thing it would a good idea to stop it during chemo days_  


   
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johan
(@j)
Joined: 4 years ago
Posts: 1190
 
Posted by: @corsaro1

@j Hi Johan,

Thank you for your prompt response, I know that Honokiol is a very effective product, do you thing it would a good idea to stop it during chemo days_  

Yes. Make sure to take magnolol with the honokiol, they appear to work best when taken together.


   
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johan
(@j)
Joined: 4 years ago
Posts: 1190
 

Regarding dosage;

Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas (xenograft mouse model, intraperitoneal injection of 20 mg/kg/day for 14 days) - Yu-Chen Cheng, Dueng-Yuan Hueng, Hua-Yin Huang, Jang-Yi Chen, and Ying Chen

Here's a dosage converter: https://dosecal.cftri.res.in/index.php

Note that in this study they administered the compounds via intraperitoneal injection, not orally. 

They used a 1:1 ratio for Honokiol: Magnolol so I'd follow the same ratio. Maybe start with 300mg each, if no negative side-effects manifest increase to 1 gram daily and titrate.

*see attached image, TMZ is temozolomide


   
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johan
(@j)
Joined: 4 years ago
Posts: 1190
 
Posted by: @j

Regarding dosage;

Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas (xenograft mouse model, intraperitoneal injection of 20 mg/kg/day for 14 days) - Yu-Chen Cheng, Dueng-Yuan Hueng, Hua-Yin Huang, Jang-Yi Chen, and Ying Chen

Here's a dosage converter: https://dosecal.cftri.res.in/index.php

Note that in this study they administered the compounds via intraperitoneal injection, not orally. 

They used a 1:1 ratio for Honokiol: Magnolol so I'd follow the same ratio. Maybe start with 300mg each, if no negative side-effects manifest increase to 1 gram daily and titrate.

*see attached image, TMZ is temozolomide

@corsaro1 I forgot to add your username in the above post, for the notification


   
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CORSARO1
(@corsaro1)
Joined: 11 months ago
Posts: 3
Topic starter  

@j Great tips and extremely useful link!

Thanks Johan


   
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