Minerval!!! Targeti...
 

Minerval!!! Targeting the Cancer's Lipid Membrane!  

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Jcancom
(@jcancom)
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25/01/2019 6:39 pm  

Minerval!

This is the first in a new line of cancer treatment targeting the abnormal lipids found in cancer. It might be related to the findings from the Brazilian bee research. A recently completed clinical trial used very large doses that apparently were non-toxic. This looks to be close to a natural product, so sourcing it should not be overly difficult.  

http://www.bioscirep.org/content/39/1/BSR20181661.full-text.pdf

http://www.lipopharma.com/index.php/en/


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Daniel
(@daniel)
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25/01/2019 7:59 pm  

Very intresting J. Do you know where you can get Minerval (2-Hydroxyoleic acid) in high quantities?

Here are some nice slides on the same  https://www.medicamentos-innovadores.org/sites/default/files/medinnovadores/Español/Eventos/2011/13_04_2011_FarmaBiotech_Onco/present_lipopharma_pharmaind_minerval_abr11.pdf

It seems that it is most relevant to brain cancer. Should I move this topic you started to the brain c section?


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Jcancom
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25/01/2019 9:11 pm  

D is quite remarkable! They dosed up to 16g in a clinical trial and then decided on a tolerated dose of 12 grams! The article below suggests that adding in glycolysis inhibitors such as 2-DG etc. might combine well. Research also talks of how biomarkers might help in selecting responders.

http://www.bioscirep.org/content/39/1/BSR20181661.full-text.pdf

I can see what you mean about the supply issue. The chemical houses have it ... at an extraordinarily high price. Oleic acid can be bought online by the gallon, yet add in another double bonded oxygen and the price increases dramatically.

If you like you could move this to the Brain Cancer Section, though it might have wider applicability. They might want to start with brain cancer as an orphan indication.

Best Wishes, Jcancom 


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Daniel
(@daniel)
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25/01/2019 9:45 pm  

J, I sent the info to Manuel - the company is Spanish and as they speak the same language, the co may decide to help them on compassionate basis with the product. Kind regards, Daniel


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Jcancom
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25/01/2019 9:58 pm  

Great Thinking D! I though that might be a good work around.


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Jcancom
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25/01/2019 10:01 pm  

It is frustrating, though how all you need to do is add a hydroxyl right by the COOH and you could convert oleic acid to 2-hydroxyoleic acid. Unfortunately, it isn't that easy.


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Jcancom
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28/01/2019 6:47 pm  

D, 2-hydroxyoleic acid has potential, especially due to its super low toxicity. Attacking the unique chemistry of the cancer cell membrane opens up an entirely new frontier of opportunity in cancer medicine.

Page 10 of the patent describes the synthesis

https://patents.google.com/patent/US20140288176A1/en?oq=US+2014%2f028817.6+A1

 


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