In Search of a Breakthrough Therapy for Glioblastoma Multiforme  


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04/10/2018 1:19 pm  

Scientific article with the above title available at

Some of the drugs suggested for repurposing as glioblastoma multiforme (GBM) therapeutics discussed in the article:

Nelfinavir PI3K-Akt signaling inhibition HIV protease inhibitor [11]
Cimetidine Immunomodulation Peptic ulcers (Histamine H2 blocker) [12]
Diclofenac Prostaglandin synthesis inhibition Inflammation and pain (COX-2
inhibitor) [13]
Nitroglycerin Nitric oxide donor Angina [14]
Thioridazine Induces autophagy and upregulates AMPK activity Antipsychotic psychosis (blocks D2b,
5-HT2A and other receptors) [15]
Pimozide Serotonin receptor-7 inhibition Antipsychotic (blocks D2 , 5-HT2A receptors, has relatively high affinity to 5-HT7 receptors) [16]
Risperidone Serotonin receptor-7 inhibition Schizophrenia, bipolar disorder, and irritability [16]
Paliperidone Serotonin receptor-7 inhibition Antipsychotic (blocks D2, 5-HT2A receptors, has relatively high affinity to 5-HT7 receptors) [16]
Apomorphine Mitochondrial metabolic gene downregulation Emetic, sometimes used in Parkinson disease. Agonist of DA2 , DA1, 5-HT2 and α-AR [17]
Flupenthixol Dopamine receptor modulation Antipsychotic (typical anti-D2-agent) [18]
Mebendazole Tubulin polymerization inhibition Nematode infestations [19]
Disulfiram Proteasome and alcohol dehydrogenase inhibition Alcoholism [20]
Valproic acid Histone deacetylase inhibition Epilepsy [21]
Levetiracetam MGMT activity inhibition Epilepsy [22]
Methadone cAMP reduction Severe pain, opioid agonist [23]
Sulfasalazine NF-κB activity suppression Inflammatory bowel disease [24]
Captopril Angiotensin-converting enzyme inhibitor Hypertension [25]
Nicardipine EGF and calcium channel antagonism Hypertension and angina [26]
Mibefradil T-type calcium channel inhibition Hypertension and angina [27]
Prazosin AKT pathway inhibition Hypertension [28]
Nimodipine Calcium channel antagonism Hypertension and angina [29]
Minocycline Apoptosis and autophagy Antibiotic has multiple known central side effects [30]
Quinidine Ornithine decarboxylase activity inhibition Heart arrhythmia [31]
Accutane Reduction of EGFR activity Acne (13-cis-retinoic acid. Has known central side effects) [32]
Thalidomide Angiogenesis inhibition Multiple myeloma, leprosy. [33]
Dichloroacetate Inhibition of anaerobic metabolism Topically: warts removal. Congenital
lactic acidosis. Inhibits pyruvate dehydrogenase kinase, which increase mitochondrial consumption of
pyruvate. [34]
Hydroxy-chloroquine Autophagy inhibition Malaria [35]
Chloroquine Oxidative stress enhancement Malaria [36]


This topic was modified 2 weeks  ago by Daniel