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Glioblastoma Alternative Treament Strategy: synergistic combination therapy of drugs, supplements and diet.

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comments and suggestions are welcome!

Daniel and Daniel reacted
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Joined: 9 years ago
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Very nice idea Johan!

Joined: 6 years ago
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Excellent Johan!

Without a doubt these molecules are key in any therapy against glioblastoma.
It is no accident that two of the long-term survivors of glioblastoma such as Ben Willians and Richard Gerber used high doses of tamoxifen and melatonin is their cocktails.
I wish I had time to write comparing both cases because we could draw interesting conclusions.
These were both treatments:

-Ben Willians:

March 31, 1995. At the age of 50, Ben underwent a subtotal resection of a large glioma (180 cubic centimeters) of the right parietal cortex, and was given an initial diagnosis of anaplastic astrocytoma, which was then improved to glioblastoma after another thorough inspection of resected tumor tissue. The extensive residual tumor was maintained after surgery.
Radiation therapy consisted of the standard 55-60 Gy in the tumor area plus 2 cm beyond the tumor limit.
The first MRI after radiation showed no shrinkage or tumor growth.
June 1995. Two weeks before his first round of chemotherapy, Ben began taking tamoxifen in high doses by mouth at a dose of 220 mg daily. Treatment with tamoxifen continued until March 1998. Side effects of tamoxifen included blood clots treated with aspirin and long walks.
July 1995. First round of intravenous chemotherapy with BCNU (carmustine) combined with 600 mg per day of verapamil during the week surrounding chemotherapy with BCNU. The verapamil was intended to block the mechanism of the drug extrusion pump in the blood-brain barrier and, therefore, increase the penetration of BCNU beyond this barrier.
The first MRI after chemotherapy showed a moderate degree of shrinkage of the tumor.
Between the first and second round of chemotherapy, Ben began taking oral Accutane (13-cis retinoic acid) at a dose of 160 mg per day in a two-week or one week rest program (then reduced the dose to 120 mg per day). ). Accutane was not taken on chemotherapy days. Accutane treatment continued until December 1995.
Also around this time, he added 15 mg melatonin per night and the immune-acting fungal supplement, the Krestin polysaccharide (PSK), at a dose of 3 grams per day. He continues to take 10 mg of melatonin to this day (2014).
August 1995. Second cycle of chemotherapy, this time consisting of oral procarbazine, oral lomustine (CCNU) and intravenous vincristine. This regimen is known as PCV. Verapamil was taken again to improve the brain's absorption of chemotherapy during the week surrounding oral lomustine treatment.
The second MRI after chemotherapy showed a "huge" reduction in the residual tumor.
Third cycle of chemotherapy, PCV.
Oral gamma linolenic acid (GLA) was added at a dose of 2-2.5 grams of GLA per day, consisting of 10 capsules of borage seed oil.
End of November. The third MRI after chemotherapy again showed a substantial reduction of the residual tumor.
In early December. Fourth cycle of chemotherapy consisting of BCNU. Ben decided to use BCNU again due to stomach pain caused by procarbazine and neuropathy caused by vincristine.
January 1996. Fourth post-chemotherapy MRI. There is no evidence of residual tumor, first "clean" MRI.
The fifth cycle of chemotherapy consisted again of BCNU, followed by another clean MRI.
The sixth and final cycle of chemotherapy consisted of PCV with half a dose of vincristine to increase its tolerability. This was followed again by another clean MRI.
Many clean MRIs followed, although Ben continued daily treatment with tamoxifen at high doses until March 1998
It is taken from

- Richard Gerber:
Metronomic temozolamide, bevacizumab (Avastin), cimetidine, celecoxib, chloroquine, tamoxifen, Accutane, verapamil, melatonin, omega 3, quercetin, GLA, mushroom PSK ....

The two benefited from high doses of verapamil by blocking the mechanism of the drug extrusion pump in the blood brain barrier by improving their respective chemo therapies. On the other hand, tamoxifen in high doses and melatonin seem to have worked in both cases. I don't think this was a coincidence....

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Thank you, Manuel. And thank you for posting the treatment cocktail for Richard Gerber, I wasn't aware of his case. 

Joined: 6 years ago
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Posted by: @daniel

Very nice idea Johan!

Thanks D. And that's the word I was looking for when I posted (but it didn't come to mind): an idea!