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Carbonic anhydrase 9 inhibition may be essential for glioblastoma  

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Daniel
(@daniel)
New Member Admin
Joined: 4 years ago
Posts: 310
16/12/2018 3:25 pm  

Carbonic anhydrase 9 (CA IX) role in cancer has been shortly discussed here https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/&source=gmail&ust=1545055684142000&usg=AFQjCNHJIctCQZU84pQAZXT1LtWqRibWB g"> https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/

In the same article I discussed available inhibitors of  CA IX.

For glioblastoma this is extra important because glioblastoma is known to be highly glycolitic. Next to that, here is literature suggesting the same:

- Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo 

- Inhibition of Carbonic Anhydrase IX in Glioblastoma Multiforme

Topiramate induces acute intracellular acidification in glioblastoma

Characterization of the mechanisms by which Carbonic Anhydrase IX facilitates tumour growth and metastasis  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0166209#downloadfiles

This topic was modified 6 months ago by Daniel

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