Carbonic anhydrase ...

Carbonic anhydrase 9 inhibition may be essential for glioblastoma  


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16/12/2018 3:25 pm  

Carbonic anhydrase 9 (CA IX) role in cancer has been shortly discussed here g">

In the same article I discussed available inhibitors of  CA IX.

For glioblastoma this is extra important because glioblastoma is known to be highly glycolitic. Next to that, here is literature suggesting the same:

- Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo 

- Inhibition of Carbonic Anhydrase IX in Glioblastoma Multiforme

Topiramate induces acute intracellular acidification in glioblastoma

Characterization of the mechanisms by which Carbonic Anhydrase IX facilitates tumour growth and metastasis

This topic was modified 9 months ago by Daniel