Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide
Dear Johan,
Thanks as always, I find it very interesting. Although the only option that would be therapeutic would be to take liposomal berberine. There is not in the market but I can "encapsulate it with empty liposomes"
I think the metabolic approach has been very advanced but although my mother is more or less well I see that the disease progresses producing many hours of intense sleep. I don't care because it has been like this for almost 2 years since regrowth.
I am seriously thinking of using previously improved lomustine with verapamil and DHA (both at high doses). A first cycle with a very low dose of lomustine around 60 mg .......
I will have to add value because I am afraid of chemo ...
kind regards
Hi Manuel, a year ago your mother's health was going downhill yet you've been able to manage her disease in an extraordinary fashion. At this stage, maybe it's best to continue to explore the least toxic therapies? Lomustine could be too tough for her to handle. The median overall survival for recurrent GBM patients taking lomustine was just 8,6 months in this study.
NADH may spark your interest.
Here's an interesting point of view:
https://www.biorxiv.org/content/biorxiv/early/2015/05/13/019307.full.pdf
"NADH therapy should be used first and if this fails then it can be
surmised that the cancer cannot respire aerobically and is fully reliant upon glycolysis. Thus,
its vulnerability is found. "
I've attached an image with results Dr. Birkmayer has obtained using NADH. Note the 2 GBM cases.
Melatonin may enhance Tamoxifen treatment: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074765/
In his book "Cancer and the New Biology of Water" Dr. Thomas Cowan MD talks about using melatonin in much higher doses in the treatment of cancer, 4 x 60mg (before breakfast, lunch, dinner, and bedtime)
@johan
Hi johan! I was doing some shorts readings about supplementation with NADH and I have some doubts.
Nicotinamide adenine dinucleotide (NAD) (NAD + in its oxidized form) is a cell proliferation stimulant. Does it favor the exchange of protons towards glycolysis ....... does this not facilitate the choice of ATP for cancer cells?
kind regards
Hi Manuel, yes I was aware of the above-mentioned information yet wanted to share the good results with NADH in cancer and the 2 cases with glioblastoma specifically. The mechanism of action isn't clear, one possibility being the interference in DNA repair, reverting the cancer cell to normal. The case studies are impressive though and as far as I know, the results obtained are by using NADH only. But many treatments have a flipside, and this one seems no different. Dr. Thomas Cowan MD, 30 years of practice, only recommends the NADH from Dr. Birkmayer, as this seems to be the NADH supplement he sees the most consistent results. I don't see any conflict of interest in his recommendation so I trust what he says. Since it's taken orally, non-toxic, produces no side effects, this might be a supplement to have available if options become scarce.
Best,
Johan
