Compositions for Modulating Cancer Stem Cells and Uses Therefor
Recently published patent:
Disclosed are compositions and methods for modulating cancer stem cells. More particularly, the present invention discloses the use of lysine demethylase (LSD) inhibitors and protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of LSD- and/or PKC-θ-overexpressing cells including cancer stem cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells, for treating cancer, including non-metastatic and metastatic cancer and/or for preventing cancer recurrence.
Therefore, this patent proposed the combo of lysine demethylase (LSD) inhibitors and protein kinase C theta inhibitors.
- LSD1 inhibitor is a MAO inhibitor -> MAO inhibitor is selected from clorgyline, pargyline and phenelzine
- PKC-θ inhibitor may be e.g. Quercetin