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Compositions for Modulating Cancer Stem Cells and Uses Therefor

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Daniel
(@daniel)
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Joined: 7 years ago
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Recently published patent:

Disclosed are compositions and methods for modulating cancer stem cells. More particularly, the present invention discloses the use of lysine demethylase (LSD) inhibitors and protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of LSD- and/or PKC-θ-overexpressing cells including cancer stem cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells, for treating cancer, including non-metastatic and metastatic cancer and/or for preventing cancer recurrence.

https://www.freepatentsonline.com/y2020/0289437.html

 

Therefore, this patent proposed the combo of lysine demethylase (LSD) inhibitors and protein kinase C theta inhibitors.

- LSD1 inhibitor is a MAO inhibitor -> MAO inhibitor is selected from clorgyline, pargyline and phenelzine

https://en.wikipedia.org/wiki/Pargyline

- PKC-θ inhibitor may be e.g. Quercetin 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961512/


   
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