Rikkunshito, a ghrelin potentiator, ameliorates anorexia–cachexia syndrome  

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johan
(@johan)
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26/05/2019 11:58 pm  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261902/

Conclusion: "Cachexia syndrome develops during the advanced stages of various chronic diseases and leads to a decreased QOL and increased rate of morbidity and mortality in patients. The Kampo medicine rikkunshito is prescribed for various upper GI syndromes, such as anorexia, and is very important in the treatment of cachexia-associated weight loss. Clinical and basic studies demonstrate that rikkunshito ameliorates anorexia and cachexia, which may be mediated by synergistically promoting endogenous ghrelin activity by several components of rikkunshito. The use of a ghrelin potentiator, such as rikkunshito, is expected to represent a novel approach for the treatment of anorexia–cachexia syndrome, which is characterized as a decrease in ghrelin signaling with both ghrelin insufficiency and resistance."

See also: The Homeostatic Force of Ghrelin: https://www.cell.com/cell-metabolism/pdf/S1550-4131(18)30119-0.pdf


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Manuone
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27/05/2019 9:03 pm  

Dear Johan,

It is a great contribution. I'm improving fat intake for my mother to gain weight.
She has not had mobility for herself since 2 years ago when she lost her vision 🙁 Inactivity is causing her to lose muscle mass, she eats fairly well, and the calorie restriction diet also has a lot of guilt.
I doubt it's from the brain tumor and I do not dare to use hydrazine sulfate.


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johan
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28/05/2019 3:52 am  

Dear Manuone, I replied on your post yesterday but it looks it got caught by a filter and it wasn't published.

What does her physician think it is? Sadly, brain tumors and/or chemotherapy can cause irreversible damage. My mother had a lymphoma in the brain, chemotherapy was effective in her case but at the same time caused her to slowly lose all functions: speech, ability to walk etcetera. In her case, the "cure" was worse than cancer.

I understand you don't want to try hydrazine sulfate, in her frail condition, because of possible serious side-effects.

It's good to hear she still has an appetite, maybe, as you pointed out,  she needs some changes in her diet to stabilize her weight?

Regards,

Johan

 


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johan
(@johan)
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01/06/2019 7:05 pm  

Btw, here's Daniel's post on cachexia, it's from a few years back but provides great insight and more ways to try and deal with this condition:

https://www.cancertreatmentsresearch.com/potential-solutions-against-cachexia-glutaminolysis-inhibitors/

 

 


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Manuone
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02/06/2019 4:46 pm  

Thank you very much Johan for the contributions.
At the moment I come to the conclusion that there is no cachexia, the loss of muscle mass is dependent on the null physical activity that she has.

Best whises


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johan
(@johan)
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Posts: 29
02/06/2019 6:09 pm  

That's good to hear, Manuone!

Here's a new study on a diet-drug combination for GBM(a ketogenic diet and the antibiotic 6-diazo-5-oxo-L-norleucine):

https://ecancer.org/news/16105-cancer-fighting-combination-targets-glioblastoma.php

"The findings support the importance of glucose and glutamine in driving glioblastoma growth and provide a therapeutic strategy for non-toxic metabolic management

 

Best Regards

 


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