Here are a few relevant elements. I will further improve the page when possible:
Artesunate (Artemisinin): Cheap anti-malaria drug shows promise against colorectal cancer
Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells
In other words, Quercetin, Ibuprofen, Statins, Apigenin, etc. will help while Butyrate may not help in this specific case, i.e when using 5FU. Note that Butyrate on the other hand will help Artesunate
Indeed, here is another article indicating Quercetin or Statins as a potential solution to inhibit MCT4 in colorectal cancer http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438655/
Mebendazole: Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer: ” Indeed as a first indication of this possibility, a patient with refractory metastatic colon cancer was treated with MBZ at the standard anthelmintic dose of 100 mg twice daily. The patient experienced no subjective adverse effects at all from the drug and computerized tomography evaluation after six weeks of therapy showed near complete remission of the metastases in the lungs and lymph nodes and a good partial remission in the liver (case report accepted for publication in Acta Oncologica).” Ref
Can be bought on eBay. Long time administration with no toxicity even at 1g/day. I will dedicate a specific post to Mebendazole. Its absorption will be improved by Cimetidine administration and if taken with fatty food that will further be improved.
2016: Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model. http://www.ncbi.nlm.nih.gov/pubmed/27612418
Cimetidine (Tagamet): Repurposing drugs in oncology (ReDO)€”cimetidine as an anti-cancer agent
Can be bough on eBay. Used at 800mg/day with food, 400mg morning and 400mg evening. I will dedicate a specific post to Cimetidine.
Aspirin: Use of Aspirin postdiagnosis improves survival for colon cancer patients
Used at a dose of 100mg/day.
Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer
Used at about 1g/day. I will dedicate a specific post to Metformin.
Pyrvinium: Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086981/
Pyrvinium pamoate – used at a dose of 5 mg/kg/day – (an Anthelmintic drug over the counter in countries like Sweden, Norway, etc.) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086981/
Glutamine deprivation: Colon cancers with PIK3CA oncogenic mutations are addicted to glutamine –
PIK3CA mutations reprogram glutamine metabolism in colorectal cancer, Nature Communications(2016) “In layman’s terms, we discovered that colon cancers with PIK3CA oncogenic mutations are addicted to glutamine, a particular nutrient for cancer cells. We also demonstrated that these cancers can be starved to death by depriving glutamine with drugs.”
Retinoic acid suppresses colorectal cancer development, study finds https://www.sciencedaily.com/releases/2016/08/160830130817.htm
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