Colon and Colorectal Cancer

Here are a few relevant elements. I will further improve the page when possible:

Artesunate (Artemisinin): Cheap anti-malaria drug shows promise against colorectal cancer 

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells 
In other words, Quercetin, Ibuprofen, Statins, Apigenin, etc. will help while Butyrate may not help in this specific case, i.e when using 5FU. Note that Butyrate on the other hand will help Artesunate

Indeed, here is another article indicating Quercetin or Statins as a potential solution to inhibit MCT4 in colorectal cancer

Mebendazole: Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer: ” Indeed as a first indication of this possibility, a patient with refractory metastatic colon cancer was treated with MBZ at the standard anthelmintic dose of 100 mg twice daily. The patient experienced no subjective adverse effects at all from the drug and computerized tomography evaluation after six weeks of therapy showed near complete remission of the metastases in the lungs and lymph nodes and a good partial remission in the liver (case report accepted for publication in Acta Oncologica).” Ref
Can be bought on eBay. Long time administration with no toxicity even at 1g/day. I will dedicate a specific post to Mebendazole. Its absorption will be improved by Cimetidine administration and if taken with fatty food that will further be improved.

2016: Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model.

Cimetidine (Tagamet)Repurposing drugs in oncology (ReDO)€”cimetidine as an anti-cancer agent 
Can be bough on eBay. Used at 800mg/day with food, 400mg morning and 400mg evening. I will dedicate a specific post to Cimetidine.

AspirinUse of Aspirin postdiagnosis improves survival for colon cancer patients
Used at a dose of 100mg/day.

CitalopramNovel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling

MetforminA Potential Therapeutic Agent for Recurrent Colon Cancer
Used at about 1g/day. I will dedicate a specific post to Metformin.

SalinomycinSalinomycin inhibits the growth of colorectal carcinoma by targeting tumor stem cells

NitazoxanideThree-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Pyrvinium: Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis
Pyrvinium pamoate – used at a dose of 5 mg/kg/day – (an Anthelmintic drug over the counter in countries like Sweden, Norway, etc.)

Glutamine deprivation: Colon cancers with PIK3CA oncogenic mutations are addicted to glutamine –
PIK3CA mutations reprogram glutamine metabolism in colorectal cancerNature Communications(2016)  “In layman’s terms, we discovered that colon cancers with PIK3CA oncogenic mutations are addicted to glutamine, a particular nutrient for cancer cells. We also demonstrated that these cancers can be starved to death by depriving glutamine with drugs.”

Retinoic acid suppresses colorectal cancer development, study finds

Related  news:


This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

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28 thoughts on “Colon and Colorectal Cancer

  1. hello D,
    a quick question; would you use Mebendazole if your were about to start on MG? i’ve read somewhere that Mebendazole might increase the LDL levels which is the major risk of taking MG too. is that a correct assumption?

    1. Hi Pouya, I would like to stay away from suggesting what to do as I am not a medical doctor.
      However, what I can say is that in general, if I would be concerned with combining multiple components, I would give priority to the most relevant and possibly include the other latter step by step.
      What are the Indian medical doctors suggesting?

  2. thanks D,
    i haven’t asked about Mebendazole yet. I’m trying to collect all the questions i have regarding the drug combinations,etc for when i get to India which i have been told, should be around 26th july. don’t worry about sharing your personal opinion, i’m not going to do anything without their consent. i take your opinion only as information. the way things work here. 🙂

    1. Hi Pouya, I am not worried. I know you are a clever reader.
      First is about your protection off course, but is also about my protection and that of the existence of this website.
      I am not here to advise, but to share my findings with all of you so that we all know more and save time for some.
      I do hope and expect the reader will do the same, i.e. sharing info and views here.

  3. Good points dear D. Totally agreed.
    One thing that made Mebendazole very interesting for me was that when i was reading about the woman that you’ve referred to in this article, i noticed that she has the KRAS mutation in common with my mom. While it might not be a decisive factor here, being in a somehow similar position i just felt like it’s worth giving this a try.

  4. I was looking for some information about DCA.
    Has anyone some knowledge that DCA could help cancer to spread?
    Text below comes from here:

    There is a publication that says DCA increases the growth of colon cancer. Is that correct?
    There is a publication which reports that DCA enhances the survival of colon cancer cells. This paper is flawed because the researchers looked at the effects of DCA on cancer cells with a complete absence of oxygen (anoxia). While hypoxia (low oxygen) may be common in tumours, anoxia (complete lack of oxygen) is not a normal situation. In very rapidly growing tumours, there will be areas of anoxia, however colon cancer generally does not behave that way. In summary, we believe our clinical findings from treating actual patients are more meaningful than this lab study done under artificial conditions. DCA (both oral and intravenous) can be an effective treatment for colon cancer based on our extensive clinical experience. DCA can cause symptom improvement, tumour shrinkage, tumour stability, or reduction in the colon cancer blood marker CEA.

  5. Hi everyone. I would like to introduce myself and my situation with the disease.
    First and foremost, I would like to thank Daniel for his generosity which can not be expressed with words. Also to the people that are going through this tremendously difficult disease that are actively participating by sharing their stories and are willing to help others, like Marcos, Ergin, Emad, Jess, Alex, Ovidiu… I’ve been reading your posts and stories.
    People like you make me keep faith in human kind…

    My name is Caio and my husband is Laurent, we live in Barcelona Spain.
    Laurent ( 47 years old) was diagnosed with colon rectal cancer in May 2017.He underwent chemo, radio and then surgery.

    Straight after the surgery, still in the hospital, he nearly died, because the stitches in his bowel opened up causing a severe peritonitis. Words can’t describe the horror I went through.
    He was left with a permanent colostomy. After the shock of all this, we started to recover and he was doing well untill 2 weeks ago that we had the news: The cancer is back.

    He went from stage II to stage IV, as it has metastasised. It seems to be a rare ( or unusual) one, as it is on a muscle (gluteus) and not on a vital organ luckily, so we are very confident about it, although there are moments where I am terrified quite frankly. It’s a rollercoaster of emotions as he means everything to me really.

    I have been doing a lot of research which brought me to cancer treatments, suggested by a post of Cancer integral in Spain on the 2-DG protocol and in the approach of cancer as a metabolic disease.

    So now it comes the part where I ask for help (the amount of information is so overwhelming I don’t know where to gest started).

    The chemo he is doing is Folfox with Panitumumab. Done one cycle. Will do 5 more, every 2 weeks. Then, possible surgery depending on the outcome.

    Some of the things I am interested:

    Anti-worm drugs.
    The idea is to combine Mebendazole, Albendazole, Fenbedazole and maybe Nitazoxanida, in synergy with Cimetidine by alternating them.
    Any thoughts on dosis or other relevant info?

    I have great interest in this medication, although I also fear about cachexia as he is a thin person normally and is even thinner lately .(70 kilos /1.83mt height). I also fear about hypoglycemia and acidosis. But I would like to get him started.
    Any thoughts on dosis or other relevant info?

    Fasting and Ketogenic diet.
    Since 4 weeks he is not eating any kind of sugars, no flours, bread, pasta, etc. Mainly proteins and fats, plus a lot of greens ( no fruit, except berries). he also fasted for 48 hours couple of times. But we also have the same concerns as the ones with metformin.

    Artesunate ( or artesiminin).
    My idea is to buy from this place in germany:
    Not sure how to best consume it though. Should it be as tea? I bought once in Spain, not sure it was the same one, it said “Ajenjo” and it turned out so extremelly bitter that is nearly impossible to drink, not sure if it t is the same stuff.

    2-DG. I would like more info on this one. Once we have a private doctor ( we will try to use this approach. It would be great however, to have idea of how much it could cost, to know if we can afford it or not.

    3-BP Same as the 2-DG. I would like to know more, Coud not find info on how/where to get ahold of.

    LDN. Very interested in this drug. But we need a prescription. We will try once whe have a private doctor.
    Any thoughts on LDN ?

    MMS. I coudn’t find scientific papers on this. Isthis a possible treatment or just quackery?

    Vitamin C IV.
    This is very pricey here in Spain ( around 2000 euros for 10 cycles).
    We are willing to give it a try, although our finance is a bit fragile at the moment, so it would be great to know if you think this is worth it.

    Itraconazol. Any one knows how to take it?

    NSAIDs. Here it gets interesting and I have a theory in his case. Laurent has had Chronic Ulcerative Colitis for almost 30 years now. I believe his cancer started because of so much inflamation and for such long time. He was never allowed to take NSAIDs, because according to the gastroenterologists they were bad to him. So he never took them.
    Interestingly enough, there are studies with some drugs being really good for colitis, such as anti worm drus like Metronidazole and LDN. Too much “coincidence” for me but no one has ever seem to have noticed this relationship. I think he coud benefit from NSAIDs so I would love to hear what you think about this.

    Also interested in other drugs such as DCA, Doxycicline and Salinomicina. But will consider that in the future as these are more complicated and there are a lot to get started with.

    We also do supplements and vitamins which I can write about in a different post, but I am trying to focus more on medicines this time.

    I apologize for such a long post, If you could point out which of those treatments are the best to start with at this point?
    Thanks in advance from the bottom of my heart.


    1. Dear Caio,

      I am very sorry to hear about the challenges you had and have and hope that your dear husband will be better and better. Thank you so much for your kind words.

      Answering your questions:
      1. Cimetidine is usually used continuous at a dose of 800mg/day. 400mg in the morning and 400 in the afternoon. While my wife used Cim for 3 years with no issues, please check interaction of Cim with other drugs you may use. Some points about this I addressed here Let you doctor know you are using this as it has to be stoped during any medical intervention due to its blood thing effects and interaction with other drugs.
      I would take care with Albendazole due to toxicity at the liver. The others you mentioned are less toxic so its nice to use them in cycles. For info on dosis etc on Mebendazole please read this and on Fenbendazole please read this
      2. Metformin is a very good one in my view and the usual target daily dose in 1500mg/day. Some people are using only 1000mg/day. It is usually started at 500mg/day and increase after a week at the target dose. Some are taking it with food to avoid some stomach issues. Some are using the light version/ slow release to avoid dome side effects.
      3. Ketogenic Diet has to be restricted. If it is simple Ketogenic diet, it can be even worse than a normal diet. Restricted KD is difficult – this is why I prefer just normal alkaline diet – you need to discuss with experts in KD if you want to go this route
      4. Artemisinin – as I understand you bought Artemisia Annua. The source is good. I like it. The one you bought in Soain and that is bitter was not Artemisia Annua but I thing Artemisia Absinthium which is also good. I would take it both as a tea and as capsules. You can easily make capsules at home. You can buy empty capsules from e.g. iHerb and buy a cheap tool that helps you make the capsules at home. More about dose etc you can find here
      5. PLease let me know what is the info you need on 2DG
      6. Info about 3BP is discussed here and in the related comments and here
      7 No need for prescription on LDN
      8. No opinion on MMS at this point but you may want to read this
      9. Vit C its always good. You can buy it from pharmacies in euro at a price of about 300 euro for 10 cycles at 50g. You need a prescription from your doctor in order to buy the IV vials. Pharmacies listed here has it
      10. The dose on Itraconazole was discussed here
      11. Regarding NSAID, Low dose Aspirin (100mg/day) for example it is known to help against colon cancer – there is scientific literature on that

      I hope thsi answers some of your questions. As you can see, a lot of the questions are already addressed on this website 🙂

      Kind regards,

  6. Great news. Last MRI showed no evidence of disease.

    Hi Daniel, first of all, thanks so much for your answer and kind wishes, I am most grateful.
    I wanted to have written before and apologise for that, last 2 months have been so overwhelming for me.
    I am very happy with the last scan from last week that showed the tumor that had metastasized is no longer visible.

    The “naive” oncologist believes it was due to chemo only, although herself said the odds of the tumour disappearing completely was about 5%. She was not even interested in knowing if we had done anything else ( surprise surprise).

    I would also like to thanks Marcos, who stayed over an hour on the phone with me and it was through him that I got to know the book “How to starve Cancer” from Jane McLelland which has helped me so much, specially to connect a lot of dots and therefore I recommend to everyone…

    So based on all the research found here on you site, Marcos’ success and what I found on the book I was able to come up with a protocol according to our budget and the availability of medicines.I basically tried to work on all the points suggested by Jane:
    Abnormal Cell Signalling, Metabolism, Growth factors and Immune Response.

    So apart from the Folfox-6 +Panitumumab chemo, the things we have done are:
    Ursolic Acid
    Glucosamine Sulphate
    Vit D3, K2 and B complex
    Red Propolis
    IV Vitamin C

    Of course it doesn’t mean there is no disease microscopically speaking, but it means the treatment really worked.
    It’s quite a lot of things and I have no way of knowing exactly which things worked which didn’t, but hey, it worked!!!

    And this time, I won’t drop the ball, I feel the first time was a wake up call, so now we’ll continue with treatment ( although I want to do some adjustments, lower a few things…) and prevent prevent prevent.

    This shows that stage IV can be controlled so I hope this inspire others to keep fighting!!!!

    I’ll keep you posted.

    Again, immensely grateful.

    1. Hi Caio,

      It so nice to hear about your very nice results!!! And thank you so much for the feedback on this website and for sharing with us your treatment strategy. Also so nice to hear that Marcos continue helping people out there.

      Have you ever had any issue with Cimetidine interacting with other drugs? Also, it would help if you could also add the dose you used for those you mentioned above.

      Thanks a lot again and congratulations for having such nice results!

      Kind regards,

    2. Hi Daniel, Hi Caio,

      My boyfriend Conway was diagnosed with Stage IV Rectal Adenocarcinoma with metastases to the liver in Sept. 2018.

      He did 7 cycles of Chemotherapy with Oxaliplatin amd Oral 5-FU TS1, with Avastin starting in the 2nd cycle and the 8th cycle doing only TS1 with Avastin.

      The last cycle was 4 March 2019 where we stopped to just do Gerson Therapy but this proved to be a diasterous decision as the therapy was not strong enough to continue the gains we achieved in the 8 rounds of chemo where the solid tunor had shrunk.a lot and the liver metastases, many had almost reached background activity with CEA down to 6.9 fron 159 at the time of diagnosis.

      5 July, 2019 showed metastases had increased in his liver with new metastases at the lungs.

      Our Onxologist on 8 July, 2019 immediately put Conway on IV Chemo Fluourosil 5-FU with Irinotecan and Target Zaltrap where we really pray the 5-FU still works!

      If it does, we hope to the Oral 5-FU TS1 with a cocktail of drugs similat to.what Laurent has done.

      I hope Caio can share with me your dosages as I know this is a final chance to save Conway.

      Daniel, if you can ask.Caio permission for us to be in touch, wr would really appreciate.

      Many thanks.


  7. Hi Ciao- Great to hear of your success and well-planned protocol. I second your recommendation of Jane’s book, it provides an organizational structure for lay people to be able to work with off label meds and supplements effectively to manage their cancer. I frequently suggest it to those fighting this battle. Wishing you continued success and the best possible outcome.

  8. Congratulations Caio!
    Congratulations also for taking the reins of your treatment! Of course this is possible! We are already many cases of “success” at least in good responses to a metabolic treatment adjuvant to conventional therapies.

    My best wishes

  9. This is great!
    We have been seeing success after success!
    It’s astonishing.
    I trace this back to donc, and Marcos.

    Everything started to gel for us with them and we have not looked back.
    I would not have guessed that this would have been possible.
    Metastatic cancer simply seemed completely hopeless, though this no longer appears to be correct.
    Metabolic approaches truly can help.

    We are now narrowing in on a treatment recipe that appears to be broadly useful.
    As Caio noted, another important insight is to recognize that metastatic cancer requires a life long commitment to
    a lifestyle adjustment. It is quite surprising to see patients who had severe metastatic illness and then a good response
    pretend that they could then continue with their lives without the understanding that they were essentially still patients
    and would be for a long time. I saw this especially with the vitamin C stage IV patients from Scotland from the 1970s. Some of them had a large response and then went back to work and then would often a relapse within a few months. It was almost hard
    to imagine that anyone would think that life could then just carry on as normal. After having one’s entire body metastatically seeded with cancer, it is completely unrealistic that life would be the same. Patients would need to understand that ongoing long term maintenance treatments would be required.
    had a large response

    I look forward to read yet more uplifting stories of success from the forum.
    Great work everyone!

    1. Dear JCancom, I too am excited about the success we are starting to see on this forum! It is only fair to also recognize the contributions you have made with all of the information you have provided, but also your optimism and enthusiasm that rally us again when there is a need for an infusion of energy! Warm regards, -Shanti

  10. Hi Daniel,
    Thanks a lot for your message and your wishes.

    Sure, I will write a post with the dosages of the protocol I gave Laurent, with pleasure. Hope it might be helpful to others.

    About your question on Cimetidine, we had no problems with it but I made sure to give at least 3 hours apart from Atorvastatin and Lorotadine ( as there seems to be “serious” interactions according to Drug Interaction Checker on Medscape).

    I also must say Laurent hasn’t had any side effects from any of the meds in these last 4 months which is very positive.

  11. Hi Shanti, thanks so much for your kind words.
    Jane’s book is indeed very good, I hope she will have an updated version soon, focusing more on the protocol and specially on dosages, that would be extremelly helpful. But I believe a revolution has already started!
    My best wishes to you too!!!

  12. Thanks for you words to Johan, Manuone and Jcancom ( I wanted to reply individually but am unable to for some reason…)
    It is a great pleasure to be able to give these great news and knowing it can inspire and encourage people in exchange for so much generosity that we find here. I hope I can keep coming here to report good news from Laurent and to hear yours to ultimately have control of this disease we are all so relentlessly fighting for.

  13. Dear Daniel,
    First at all thanks you very much for your kindness and generosity.
    I am a just retired physician.
    About a colon rectal cancer friend of mine with BRAF V600E mutation positive and early biologyical therapy, encorafenid plus cetuximab . A tyrosine kinase inhibitor (TKI) and monoclonal antibody – binds to the epidermal growth factor receptors (EGFR)- respectively. Initiatly the chemoherapy was no effective- and showed nephrotoxicity.
    I wonder if you have information about yes or no conveniency mix to cocktail off-labels drugs.
    I woul appreciate you any information about.
    My best wishes I am geateful you.
    Francisco Ramirez

    1. Dear Francisco,

      Thank you for your kind words and question.

      Here you can find many relevant subjects on CRC
      Also, read the first case report presented here

      Below are some more ideas for drugs and supplements that could be considered as a part of a cocktail of off-label drugs for CRC:

      – Anti parasites
      – Mechanistically, ivermectin appears to indirectly alter the levels of C-terminally phosphorylated β-CATENIN forms, leading to a decrease WNT-TCF signaling transcriptional response. This is very important in Colorecta Cancer

      – inhibition of the WNT/β-CATENIN pathway is dependent on increased N-terminal phosphorylation of β-CATENIN
      – it has low systemic resorption and very few side effects, even at high doses during long-term use
      – Mesalamine, Folic Acid Cut Cancer Risk in IBD

      – Low-dose aspirin (also called anti-platelet doses, i.e. 75 mg/day corresponding to 15–20 μM of salicylic acid in plasma) prevent platelets from binding to tumor cells but also inhibit cancer cell proliferation through the inhibition of platelet-derived signals necessary for the upregulation of the oncoprotein c-MYC

      – we have observed that disulfiram in combination with copper significantly increases the anti-tumor effects of irinotecan in oxaliplatin resistant CRC cells or increases the effects of oxaliplatin in irinotecan resistant mCRC cells

      – antifungal, antiworms drug
      – glycolysis inhibitor
      – previously unappreciated CYP monooxygenase pathway is upregulated in colon cancer, contributes to its pathogenesis, and could be therapeutically explored for preventing or treating colon cancer.
      – Clotrimazole as a Cancer Drug: A Short Review

      – Best statin in terms of pharmacokinetics
      – To be taken every 12 hours
      – Statins are good against colorectal cancer

      – 2g/day
      – old anthelmintic drug
      – Good against colorectal cancer
      – inhibition of Wnt/βcatenin signaling, important in colorectal cancer
      – Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial

      Many anti-cancer clinics around the world give Cimetidine to patients in order to reduce the chance of metastasis.
      800mg/day (400mg in the morning and 400mg in the evening), with or after food.
      Source – Where to buy:
      can be found on eBay under the name Tagamet or Equate.
      Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumor cells. “These results clearly indicate that cimetidine treatment dramatically improved survival in colorectal cancer patients with tumor cells expressing high levels of sL(x) and sL(a).”
      The Effect of Perioperative Cimetidine Administration on Time to Colorectal Cancer Recurrence
      Perioperative cimetidine administration improves systematic immune response and tumor infiltrating lymphocytes in patients with colorectal cancer.
      Repurposing drugs in oncology (ReDO)—Cimetidine as an anti-cancer agent

      It can be taken at a dose of minimum 200mg/day, in the evening, with fatty food around the same time as Cimetidine. Combining with fatty food and taking it at the same time with Cimetidine will improve its absorption.
      Source – Where to buy:
      It can be found on e.g. eBay
      Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer
      Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent

      Artemisinin and Artesunate
      References: A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer.

      Quercetin is another one relevant here.

      I hope this helps.

      Kind regards,

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