Colon and Colorectal Cancer

Here are a few relevant elements. I will further improve the page when possible:

Artesunate (Artemisinin): Cheap anti-malaria drug shows promise against colorectal cancer 

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells 
In other words, Quercetin, Ibuprofen, Statins, Apigenin, etc. will help while Butyrate may not help in this specific case, i.e when using 5FU. Note that Butyrate on the other hand will help Artesunate

Indeed, here is another article indicating Quercetin or Statins as a potential solution to inhibit MCT4 in colorectal cancer http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438655/

Mebendazole: Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer: ” Indeed as a first indication of this possibility, a patient with refractory metastatic colon cancer was treated with MBZ at the standard anthelmintic dose of 100 mg twice daily. The patient experienced no subjective adverse effects at all from the drug and computerized tomography evaluation after six weeks of therapy showed near complete remission of the metastases in the lungs and lymph nodes and a good partial remission in the liver (case report accepted for publication in Acta Oncologica).” Ref
Can be bought on eBay. Long time administration with no toxicity even at 1g/day. I will dedicate a specific post to Mebendazole. Its absorption will be improved by Cimetidine administration and if taken with fatty food that will further be improved.

2016: Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model. http://www.ncbi.nlm.nih.gov/pubmed/27612418

Cimetidine (Tagamet)Repurposing drugs in oncology (ReDO)€”cimetidine as an anti-cancer agent 
Can be bough on eBay. Used at 800mg/day with food, 400mg morning and 400mg evening. I will dedicate a specific post to Cimetidine.

AspirinUse of Aspirin postdiagnosis improves survival for colon cancer patients
Used at a dose of 100mg/day.

CitalopramNovel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling

MetforminA Potential Therapeutic Agent for Recurrent Colon Cancer
Used at about 1g/day. I will dedicate a specific post to Metformin.

SalinomycinSalinomycin inhibits the growth of colorectal carcinoma by targeting tumor stem cells

NitazoxanideThree-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Pyrvinium: Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086981/
Pyrvinium pamoate – used at a dose of 5 mg/kg/day – (an Anthelmintic drug over the counter in countries like Sweden, Norway, etc.) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086981/

Glutamine deprivation: Colon cancers with PIK3CA oncogenic mutations are addicted to glutamine –
PIK3CA mutations reprogram glutamine metabolism in colorectal cancerNature Communications(2016)  “In layman’s terms, we discovered that colon cancers with PIK3CA oncogenic mutations are addicted to glutamine, a particular nutrient for cancer cells. We also demonstrated that these cancers can be starved to death by depriving glutamine with drugs.”

Retinoic acid suppresses colorectal cancer development, study finds https://www.sciencedaily.com/releases/2016/08/160830130817.htm

Related  news:

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Related Articles


7
Leave a Reply

Please Login to comment
avatar
  Subscribe  
Notify of
Pouya
Member

hello D,
a quick question; would you use Mebendazole if your were about to start on MG? i’ve read somewhere that Mebendazole might increase the LDL levels which is the major risk of taking MG too. is that a correct assumption?

Pouya
Member

thanks D,
i haven’t asked about Mebendazole yet. I’m trying to collect all the questions i have regarding the drug combinations,etc for when i get to India which i have been told, should be around 26th july. don’t worry about sharing your personal opinion, i’m not going to do anything without their consent. i take your opinion only as information. the way things work here. 🙂

Pouya
Member

Good points dear D. Totally agreed.
One thing that made Mebendazole very interesting for me was that when i was reading about the woman that you’ve referred to in this article, i noticed that she has the KRAS mutation in common with my mom. While it might not be a decisive factor here, being in a somehow similar position i just felt like it’s worth giving this a try.

anna
Member

I was looking for some information about DCA.
Has anyone some knowledge that DCA could help cancer to spread?
Text below comes from here:

http://medicorcancer.com/dca-dichloroacetate-frequently-asked-questions/

There is a publication that says DCA increases the growth of colon cancer. Is that correct?
There is a publication which reports that DCA enhances the survival of colon cancer cells. This paper is flawed because the researchers looked at the effects of DCA on cancer cells with a complete absence of oxygen (anoxia). While hypoxia (low oxygen) may be common in tumours, anoxia (complete lack of oxygen) is not a normal situation. In very rapidly growing tumours, there will be areas of anoxia, however colon cancer generally does not behave that way. In summary, we believe our clinical findings from treating actual patients are more meaningful than this lab study done under artificial conditions. DCA (both oral and intravenous) can be an effective treatment for colon cancer based on our extensive clinical experience. DCA can cause symptom improvement, tumour shrinkage, tumour stability, or reduction in the colon cancer blood marker CEA.