Colon and Colorectal Cancer

Here are a few relevant elements. I will further improve the page when possible:

Artesunate (Artemisinin): Cheap anti-malaria drug shows promise against colorectal cancer 

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells 
In other words, Quercetin, Ibuprofen, Statins, Apigenin, etc. will help while Butyrate may not help in this specific case, i.e when using 5FU. Note that Butyrate on the other hand will help Artesunate

Indeed, here is another article indicating Quercetin or Statins as a potential solution to inhibit MCT4 in colorectal cancer http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438655/

Mebendazole: Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer: ” Indeed as a first indication of this possibility, a patient with refractory metastatic colon cancer was treated with MBZ at the standard anthelmintic dose of 100 mg twice daily. The patient experienced no subjective adverse effects at all from the drug and computerized tomography evaluation after six weeks of therapy showed near complete remission of the metastases in the lungs and lymph nodes and a good partial remission in the liver (case report accepted for publication in Acta Oncologica).” Ref
Can be bought on eBay. Long time administration with no toxicity even at 1g/day. I will dedicate a specific post to Mebendazole. Its absorption will be improved by Cimetidine administration and if taken with fatty food that will further be improved.

2016: Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model. http://www.ncbi.nlm.nih.gov/pubmed/27612418

Cimetidine (Tagamet)Repurposing drugs in oncology (ReDO)€”cimetidine as an anti-cancer agent 
Can be bough on eBay. Used at 800mg/day with food, 400mg morning and 400mg evening. I will dedicate a specific post to Cimetidine.

AspirinUse of Aspirin postdiagnosis improves survival for colon cancer patients
Used at a dose of 100mg/day.

CitalopramNovel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling

MetforminA Potential Therapeutic Agent for Recurrent Colon Cancer
Used at about 1g/day. I will dedicate a specific post to Metformin.

SalinomycinSalinomycin inhibits the growth of colorectal carcinoma by targeting tumor stem cells

NitazoxanideThree-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Pyrvinium: Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086981/
Pyrvinium pamoate – used at a dose of 5 mg/kg/day – (an Anthelmintic drug over the counter in countries like Sweden, Norway, etc.) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086981/

Glutamine deprivation: Colon cancers with PIK3CA oncogenic mutations are addicted to glutamine –
PIK3CA mutations reprogram glutamine metabolism in colorectal cancerNature Communications(2016)  “In layman’s terms, we discovered that colon cancers with PIK3CA oncogenic mutations are addicted to glutamine, a particular nutrient for cancer cells. We also demonstrated that these cancers can be starved to death by depriving glutamine with drugs.”

Retinoic acid suppresses colorectal cancer development, study finds https://www.sciencedaily.com/releases/2016/08/160830130817.htm

Related  news:

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

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47 thoughts on “Colon and Colorectal Cancer

  1. hello D,
    a quick question; would you use Mebendazole if your were about to start on MG? i’ve read somewhere that Mebendazole might increase the LDL levels which is the major risk of taking MG too. is that a correct assumption?

    1. Hi Pouya, I would like to stay away from suggesting what to do as I am not a medical doctor.
      However, what I can say is that in general, if I would be concerned with combining multiple components, I would give priority to the most relevant and possibly include the other latter step by step.
      What are the Indian medical doctors suggesting?

  2. thanks D,
    i haven’t asked about Mebendazole yet. I’m trying to collect all the questions i have regarding the drug combinations,etc for when i get to India which i have been told, should be around 26th july. don’t worry about sharing your personal opinion, i’m not going to do anything without their consent. i take your opinion only as information. the way things work here. 🙂

    1. Hi Pouya, I am not worried. I know you are a clever reader.
      First is about your protection off course, but is also about my protection and that of the existence of this website.
      I am not here to advise, but to share my findings with all of you so that we all know more and save time for some.
      I do hope and expect the reader will do the same, i.e. sharing info and views here.

  3. Good points dear D. Totally agreed.
    One thing that made Mebendazole very interesting for me was that when i was reading about the woman that you’ve referred to in this article, i noticed that she has the KRAS mutation in common with my mom. While it might not be a decisive factor here, being in a somehow similar position i just felt like it’s worth giving this a try.

  4. I was looking for some information about DCA.
    Has anyone some knowledge that DCA could help cancer to spread?
    Text below comes from here:

    http://medicorcancer.com/dca-dichloroacetate-frequently-asked-questions/

    There is a publication that says DCA increases the growth of colon cancer. Is that correct?
    There is a publication which reports that DCA enhances the survival of colon cancer cells. This paper is flawed because the researchers looked at the effects of DCA on cancer cells with a complete absence of oxygen (anoxia). While hypoxia (low oxygen) may be common in tumours, anoxia (complete lack of oxygen) is not a normal situation. In very rapidly growing tumours, there will be areas of anoxia, however colon cancer generally does not behave that way. In summary, we believe our clinical findings from treating actual patients are more meaningful than this lab study done under artificial conditions. DCA (both oral and intravenous) can be an effective treatment for colon cancer based on our extensive clinical experience. DCA can cause symptom improvement, tumour shrinkage, tumour stability, or reduction in the colon cancer blood marker CEA.

  5. Hi everyone. I would like to introduce myself and my situation with the disease.
    First and foremost, I would like to thank Daniel for his generosity which can not be expressed with words. Also to the people that are going through this tremendously difficult disease that are actively participating by sharing their stories and are willing to help others, like Marcos, Ergin, Emad, Jess, Alex, Ovidiu… I’ve been reading your posts and stories.
    People like you make me keep faith in human kind…

    My name is Caio and my husband is Laurent, we live in Barcelona Spain.
    Laurent ( 47 years old) was diagnosed with colon rectal cancer in May 2017.He underwent chemo, radio and then surgery.

    Straight after the surgery, still in the hospital, he nearly died, because the stitches in his bowel opened up causing a severe peritonitis. Words can’t describe the horror I went through.
    He was left with a permanent colostomy. After the shock of all this, we started to recover and he was doing well untill 2 weeks ago that we had the news: The cancer is back.

    He went from stage II to stage IV, as it has metastasised. It seems to be a rare ( or unusual) one, as it is on a muscle (gluteus) and not on a vital organ luckily, so we are very confident about it, although there are moments where I am terrified quite frankly. It’s a rollercoaster of emotions as he means everything to me really.

    I have been doing a lot of research which brought me to cancer treatments research.com, suggested by a post of Cancer integral in Spain on the 2-DG protocol and in the approach of cancer as a metabolic disease.

    So now it comes the part where I ask for help (the amount of information is so overwhelming I don’t know where to gest started).

    The chemo he is doing is Folfox with Panitumumab. Done one cycle. Will do 5 more, every 2 weeks. Then, possible surgery depending on the outcome.

    Some of the things I am interested:

    Anti-worm drugs.
    The idea is to combine Mebendazole, Albendazole, Fenbedazole and maybe Nitazoxanida, in synergy with Cimetidine by alternating them.
    Any thoughts on dosis or other relevant info?

    Metformin.
    I have great interest in this medication, although I also fear about cachexia as he is a thin person normally and is even thinner lately .(70 kilos /1.83mt height). I also fear about hypoglycemia and acidosis. But I would like to get him started.
    Any thoughts on dosis or other relevant info?

    Fasting and Ketogenic diet.
    Since 4 weeks he is not eating any kind of sugars, no flours, bread, pasta, etc. Mainly proteins and fats, plus a lot of greens ( no fruit, except berries). he also fasted for 48 hours couple of times. But we also have the same concerns as the ones with metformin.

    Artesunate ( or artesiminin).
    My idea is to buy from this place in germany: https://www.teemana.com/en/produkt/artemisia-annua-anamed-a-3-broken/
    Not sure how to best consume it though. Should it be as tea? I bought once in Spain, not sure it was the same one, it said “Ajenjo” and it turned out so extremelly bitter that is nearly impossible to drink, not sure if it t is the same stuff.

    2-DG. I would like more info on this one. Once we have a private doctor ( we will try to use this approach. It would be great however, to have idea of how much it could cost, to know if we can afford it or not.

    3-BP Same as the 2-DG. I would like to know more, Coud not find info on how/where to get ahold of.

    LDN. Very interested in this drug. But we need a prescription. We will try once whe have a private doctor.
    Any thoughts on LDN ?

    MMS. I coudn’t find scientific papers on this. Isthis a possible treatment or just quackery?

    Vitamin C IV.
    This is very pricey here in Spain ( around 2000 euros for 10 cycles).
    We are willing to give it a try, although our finance is a bit fragile at the moment, so it would be great to know if you think this is worth it.

    Itraconazol. Any one knows how to take it?

    NSAIDs. Here it gets interesting and I have a theory in his case. Laurent has had Chronic Ulcerative Colitis for almost 30 years now. I believe his cancer started because of so much inflamation and for such long time. He was never allowed to take NSAIDs, because according to the gastroenterologists they were bad to him. So he never took them.
    Interestingly enough, there are studies with some drugs being really good for colitis, such as anti worm drus like Metronidazole and LDN. Too much “coincidence” for me but no one has ever seem to have noticed this relationship. I think he coud benefit from NSAIDs so I would love to hear what you think about this.

    Also interested in other drugs such as DCA, Doxycicline and Salinomicina. But will consider that in the future as these are more complicated and there are a lot to get started with.

    We also do supplements and vitamins which I can write about in a different post, but I am trying to focus more on medicines this time.

    I apologize for such a long post, If you could point out which of those treatments are the best to start with at this point?
    Thanks in advance from the bottom of my heart.

    Caio.

    1. Dear Caio,

      I am very sorry to hear about the challenges you had and have and hope that your dear husband will be better and better. Thank you so much for your kind words.

      Answering your questions:
      1. Cimetidine is usually used continuous at a dose of 800mg/day. 400mg in the morning and 400 in the afternoon. While my wife used Cim for 3 years with no issues, please check interaction of Cim with other drugs you may use. Some points about this I addressed here https://www.cancertreatmentsresearch.com/tips-on-treatments-a-list-to-be-constantly-updated/ Let you doctor know you are using this as it has to be stoped during any medical intervention due to its blood thing effects and interaction with other drugs.
      I would take care with Albendazole due to toxicity at the liver. The others you mentioned are less toxic so its nice to use them in cycles. For info on dosis etc on Mebendazole please read this https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/ and on Fenbendazole please read this https://www.cancertreatmentsresearch.com/fenbendazole/
      2. Metformin is a very good one in my view and the usual target daily dose in 1500mg/day. Some people are using only 1000mg/day. It is usually started at 500mg/day and increase after a week at the target dose. Some are taking it with food to avoid some stomach issues. Some are using the light version/ slow release to avoid dome side effects.
      3. Ketogenic Diet has to be restricted. If it is simple Ketogenic diet, it can be even worse than a normal diet. Restricted KD is difficult – this is why I prefer just normal alkaline diet – you need to discuss with experts in KD if you want to go this route
      4. Artemisinin – as I understand you bought Artemisia Annua. The source is good. I like it. The one you bought in Soain and that is bitter was not Artemisia Annua but I thing Artemisia Absinthium which is also good. I would take it both as a tea and as capsules. You can easily make capsules at home. You can buy empty capsules from e.g. iHerb and buy a cheap tool that helps you make the capsules at home. More about dose etc you can find here https://www.cancertreatmentsresearch.com/artemisia-annua-its-extract-artemisinin/
      5. PLease let me know what is the info you need on 2DG
      6. Info about 3BP is discussed here and in the related comments https://www.cancertreatmentsresearch.com/3-bromopyruvate/ and here https://www.cancertreatmentsresearch.com/3bp-administration-protocol-and-treatment-strategy/
      7 No need for prescription on LDN https://www.buyldn.com
      8. No opinion on MMS at this point but you may want to read this https://www.cancertreatmentsresearch.com/community/forum-to-discuss-treatment-protocols-and-drugsupplement-cocktail/chlorine-dioxide-metabolic-treatment/#post-646
      9. Vit C its always good. You can buy it from pharmacies in euro at a price of about 300 euro for 10 cycles at 50g. You need a prescription from your doctor in order to buy the IV vials. Pharmacies listed here has it https://www.cancertreatmentsresearch.com/suppliers/
      10. The dose on Itraconazole was discussed here https://www.cancertreatmentsresearch.com/itraconazole/
      11. Regarding NSAID, Low dose Aspirin (100mg/day) for example it is known to help against colon cancer – there is scientific literature on that

      I hope thsi answers some of your questions. As you can see, a lot of the questions are already addressed on this website 🙂

      Kind regards,
      Daniel

  6. Great news. Last MRI showed no evidence of disease.

    Hi Daniel, first of all, thanks so much for your answer and kind wishes, I am most grateful.
    I wanted to have written before and apologise for that, last 2 months have been so overwhelming for me.
    I am very happy with the last scan from last week that showed the tumor that had metastasized is no longer visible.

    The “naive” oncologist believes it was due to chemo only, although herself said the odds of the tumour disappearing completely was about 5%. She was not even interested in knowing if we had done anything else ( surprise surprise).

    I would also like to thanks Marcos, who stayed over an hour on the phone with me and it was through him that I got to know the book “How to starve Cancer” from Jane McLelland which has helped me so much, specially to connect a lot of dots and therefore I recommend to everyone…

    So based on all the research found here on you site, Marcos’ success and what I found on the book I was able to come up with a protocol according to our budget and the availability of medicines.I basically tried to work on all the points suggested by Jane:
    Abnormal Cell Signalling, Metabolism, Growth factors and Immune Response.

    So apart from the Folfox-6 +Panitumumab chemo, the things we have done are:
    Mebendazole
    Febendazole
    Dipyridamole
    Doxycycline
    Metformin
    Atorvastatin
    Berberine
    LDN
    DCA
    Melatonin
    Cimetidine
    Curcumin
    Hydroxitrate
    Ursolic Acid
    EGCG
    Glucosamine Sulphate
    Loratadine
    Vit D3, K2 and B complex
    Zinc
    Red Propolis
    IV Vitamin C

    Of course it doesn’t mean there is no disease microscopically speaking, but it means the treatment really worked.
    It’s quite a lot of things and I have no way of knowing exactly which things worked which didn’t, but hey, it worked!!!

    And this time, I won’t drop the ball, I feel the first time was a wake up call, so now we’ll continue with treatment ( although I want to do some adjustments, lower a few things…) and prevent prevent prevent.

    This shows that stage IV can be controlled so I hope this inspire others to keep fighting!!!!

    I’ll keep you posted.

    Again, immensely grateful.

    1. Hi Caio,

      It so nice to hear about your very nice results!!! And thank you so much for the feedback on this website and for sharing with us your treatment strategy. Also so nice to hear that Marcos continue helping people out there.

      Have you ever had any issue with Cimetidine interacting with other drugs? Also, it would help if you could also add the dose you used for those you mentioned above.

      Thanks a lot again and congratulations for having such nice results!

      Kind regards,
      Daniel

    2. Hi Daniel, Hi Caio,

      My boyfriend Conway was diagnosed with Stage IV Rectal Adenocarcinoma with metastases to the liver in Sept. 2018.

      He did 7 cycles of Chemotherapy with Oxaliplatin amd Oral 5-FU TS1, with Avastin starting in the 2nd cycle and the 8th cycle doing only TS1 with Avastin.

      The last cycle was 4 March 2019 where we stopped to just do Gerson Therapy but this proved to be a diasterous decision as the therapy was not strong enough to continue the gains we achieved in the 8 rounds of chemo where the solid tunor had shrunk.a lot and the liver metastases, many had almost reached background activity with CEA down to 6.9 fron 159 at the time of diagnosis.

      5 July, 2019 showed metastases had increased in his liver with new metastases at the lungs.

      Our Onxologist on 8 July, 2019 immediately put Conway on IV Chemo Fluourosil 5-FU with Irinotecan and Target Zaltrap where we really pray the 5-FU still works!

      If it does, we hope to just.do the Oral 5-FU TS1 with a cocktail of drugs similat to.what Laurent has done.

      I hope Caio that.you can share with me your dosages as I know this is a final chance to save Conway.

      Daniel, if you can ask.Caio permission for us to be in touch, wr would really appreciate.

      Many thanks.

      Ada

  7. Hi Ciao- Great to hear of your success and well-planned protocol. I second your recommendation of Jane’s book, it provides an organizational structure for lay people to be able to work with off label meds and supplements effectively to manage their cancer. I frequently suggest it to those fighting this battle. Wishing you continued success and the best possible outcome.
    -Shanti

  8. Congratulations Caio!
    Congratulations also for taking the reins of your treatment! Of course this is possible! We are already many cases of “success” at least in good responses to a metabolic treatment adjuvant to conventional therapies.

    My best wishes

  9. This is great!
    We have been seeing success after success!
    It’s astonishing.
    I trace this back to donc, and Marcos.

    Everything started to gel for us with them and we have not looked back.
    I would not have guessed that this would have been possible.
    Metastatic cancer simply seemed completely hopeless, though this no longer appears to be correct.
    Metabolic approaches truly can help.

    We are now narrowing in on a treatment recipe that appears to be broadly useful.
    As Caio noted, another important insight is to recognize that metastatic cancer requires a life long commitment to
    a lifestyle adjustment. It is quite surprising to see patients who had severe metastatic illness and then a good response
    pretend that they could then continue with their lives without the understanding that they were essentially still patients
    and would be for a long time. I saw this especially with the vitamin C stage IV patients from Scotland from the 1970s. Some of them had a large response and then went back to work and then would often a relapse within a few months. It was almost hard
    to imagine that anyone would think that life could then just carry on as normal. After having one’s entire body metastatically seeded with cancer, it is completely unrealistic that life would be the same. Patients would need to understand that ongoing long term maintenance treatments would be required.
    had a large response

    I look forward to read yet more uplifting stories of success from the forum.
    Great work everyone!

    1. Dear JCancom, I too am excited about the success we are starting to see on this forum! It is only fair to also recognize the contributions you have made with all of the information you have provided, but also your optimism and enthusiasm that rally us again when there is a need for an infusion of energy! Warm regards, -Shanti

  10. Hi Daniel,
    Thanks a lot for your message and your wishes.

    Sure, I will write a post with the dosages of the protocol I gave Laurent, with pleasure. Hope it might be helpful to others.

    About your question on Cimetidine, we had no problems with it but I made sure to give at least 3 hours apart from Atorvastatin and Lorotadine ( as there seems to be “serious” interactions according to Drug Interaction Checker on Medscape).

    I also must say Laurent hasn’t had any side effects from any of the meds in these last 4 months which is very positive.

  11. Hi Shanti, thanks so much for your kind words.
    Jane’s book is indeed very good, I hope she will have an updated version soon, focusing more on the protocol and specially on dosages, that would be extremelly helpful. But I believe a revolution has already started!
    My best wishes to you too!!!

  12. Thanks for you words to Johan, Manuone and Jcancom ( I wanted to reply individually but am unable to for some reason…)
    It is a great pleasure to be able to give these great news and knowing it can inspire and encourage people in exchange for so much generosity that we find here. I hope I can keep coming here to report good news from Laurent and to hear yours to ultimately have control of this disease we are all so relentlessly fighting for.

  13. Dear Daniel,
    First at all thanks you very much for your kindness and generosity.
    I am a just retired physician.
    About a colon rectal cancer friend of mine with BRAF V600E mutation positive and early biologyical therapy, encorafenid plus cetuximab . A tyrosine kinase inhibitor (TKI) and monoclonal antibody – binds to the epidermal growth factor receptors (EGFR)- respectively. Initiatly the chemoherapy was no effective- and showed nephrotoxicity.
    I wonder if you have information about yes or no conveniency mix to cocktail off-labels drugs.
    I woul appreciate you any information about.
    My best wishes I am geateful you.
    Francisco Ramirez

    1. Dear Francisco,

      Thank you for your kind words and question.

      Here you can find many relevant subjects on CRC https://www.cancertreatmentsresearch.com/community/colon-cancer-colorectal-cancer/
      Also, read the first case report presented here https://www.cancertreatmentsresearch.com/10-cases-of-complete-remission-from-stage-4-cancers-after-using-supplements-or-repurposed-drugs/

      Below are some more ideas for drugs and supplements that could be considered as a part of a cocktail of off-label drugs for CRC:

      Ivermectin
      – Anti parasites
      – Mechanistically, ivermectin appears to indirectly alter the levels of C-terminally phosphorylated β-CATENIN forms, leading to a decrease WNT-TCF signaling transcriptional response. This is very important in Colorecta Cancer

      Mesalamine
      – inhibition of the WNT/β-CATENIN pathway is dependent on increased N-terminal phosphorylation of β-CATENIN
      – it has low systemic resorption and very few side effects, even at high doses during long-term use
      – Mesalamine, Folic Acid Cut Cancer Risk in IBD https://www.mdedge.com/familymedicine/article/27225/gastroenterology/mesalamine-folic-acid-cut-cancer-risk-ibd

      Aspirin
      – Low-dose aspirin (also called anti-platelet doses, i.e. 75 mg/day corresponding to 15–20 μM of salicylic acid in plasma) prevent platelets from binding to tumor cells but also inhibit cancer cell proliferation through the inhibition of platelet-derived signals necessary for the upregulation of the oncoprotein c-MYC

      Disulfiram
      – we have observed that disulfiram in combination with copper significantly increases the anti-tumor effects of irinotecan in oxaliplatin resistant CRC cells or increases the effects of oxaliplatin in irinotecan resistant mCRC cells http://www.clinicsinoncology.com/pdfs_folder/cio-v2-id1382.pdf

      Clotrimazole
      – antifungal, antiworms drug
      – glycolysis inhibitor
      – previously unappreciated CYP monooxygenase pathway is upregulated in colon cancer, contributes to its pathogenesis, and could be therapeutically explored for preventing or treating colon cancer. http://sci-hub.tw/http://cancerres.aacrjournals.org/content/early/2019/02/19/0008-5472.CAN-18-3221?_ga=2.134998001.1449224114.1562880536-2082747498.1562880536
      – Clotrimazole as a Cancer Drug: A Short Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724869/

      Pitavastatin
      – Best statin in terms of pharmacokinetics http://sci-hub.tw/https://www.sciencedirect.com/science/article/pii/S030573721830104X
      – To be taken every 12 hours
      – Statins are good against colorectal cancer http://sci-hub.tw/https://link.springer.com/article/10.1007%2Fs00018-019-03134-0

      Niclosamide
      – 2g/day https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4197-9
      – old anthelmintic drug
      – Good against colorectal cancer http://sci-hub.tw/https://link.springer.com/article/10.1007%2Fs00018-019-03134-0
      – inhibition of Wnt/βcatenin signaling, important in colorectal cancer
      – Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4197-9

      Cimetidine
      Many anti-cancer clinics around the world give Cimetidine to patients in order to reduce the chance of metastasis.
      Administration:
      800mg/day (400mg in the morning and 400mg in the evening), with or after food.
      Source – Where to buy:
      can be found on eBay under the name Tagamet or Equate.
      References:
      Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumor cells. “These results clearly indicate that cimetidine treatment dramatically improved survival in colorectal cancer patients with tumor cells expressing high levels of sL(x) and sL(a).” https://www.ncbi.nlm.nih.gov/pubmed/11870500/
      The Effect of Perioperative Cimetidine Administration on Time to Colorectal Cancer Recurrence https://www.ncbi.nlm.nih.gov/pubmed/29630589
      Perioperative cimetidine administration improves systematic immune response and tumor infiltrating lymphocytes in patients with colorectal cancer. https://www.ncbi.nlm.nih.gov/pubmed/22944376
      Repurposing drugs in oncology (ReDO)—Cimetidine as an anti-cancer agent https://ecancer.org/journal/8/485-repurposing-drugs-in-oncology-redo-cimetidine-as-an-anti-cancer-agent.php

      Mebendazole
      Administration:
      It can be taken at a dose of minimum 200mg/day, in the evening, with fatty food around the same time as Cimetidine. Combining with fatty food and taking it at the same time with Cimetidine will improve its absorption.
      Source – Where to buy:
      It can be found on e.g. eBay
      Reference:
      Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer https://www.ncbi.nlm.nih.gov/pubmed/24160353
      Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/

      Artemisinin and Artesunate
      References: A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer. https://www.ncbi.nlm.nih.gov/pubmed/26137537

      Quercetin is another one relevant here.

      I hope this helps.

      Kind regards,
      Daniel

  14. Good morning Daniel
    I would really appreciate if you could help me with a friend of our, he is 74 years old, he was diagnosed with stage 4 colorectal cancer with metastasis in the kidney and the lungs, the main tumor in the colon closed down the whole colon so it had to be removed, he also has a history of 2 strokes with hemorrhage in the brain, and very weak kidneys the doctors told him they are on the edge of failing, so because of this he won’t be able to tolerate the folfoxi chemotherapy, they are currently giving him a weaker chemotherapy in the form of Oxaliplatin 100 mg every 3 weeks and xeloda (capecitabine 1000 mg bid) for 2 weeks then 1 week break .
    We would really love to know if there are any medications that could benefit him, also if there is any thing he could do to protect his kidneys so they can process the chemo he is currently taking
    Thanks a lot for your time and help

    1. Dear User10000,

      I apologize for the delay of my response.

      There is so much that can be done, as discussed in many posts on this website. The drug in the case #1 presented here could be a relevant option https://www.cancertreatmentsresearch.com/10-cases-of-complete-remission-from-stage-4-cancers-after-using-supplements-or-repurposed-drugs/

      Mebendazole can be another option to consider https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/?highlight=mebendazole

      Many other options are addressed here https://www.cancertreatmentsresearch.com/community/colon-cancer-colorectal-cancer/

      For kidneys support, I would consider Astragalus.

      Kind regards,
      Daniel

  15. Good Morning Daniel and all others reading this,
    Below is my story in brief.
    I would really appreciate whatever your thoughts are on my questions.

    March 2019 – Cancer in Sigmoid colon, removed by surgery. No mutations – No KRAS, No BRAF, No NRAS, No PIK3CA – microsatellite stable. All MMR protein expressions intact..

    Took one cycle of XELODA adjuvant Chemotherapy post surgery, could not continue to due to severe side effects.
    Immediately started Joe Tippens protocol as a prophylaxis.

    June 2021 – Single large lesion metastases, 5 cms, is discovered in Liver, segment 5 & 6. ( So, presumably JT protocol did not work)

    Started C.O.C protocol and FOLFOX6 Chemotherapy.
    November 2021 – Liver lesion completely disappeared after FOLFOX6 – 8 cycles. Clear PET scan.

    January 2022 – Liver lesion appears again on same spot, just within 3 months of ending Chemotherapy. Tumor size is 4cm

    I have been advised liver resection surgery, which will remove complete right half of the liver along with the gall bladder.

    Do I have any choices besides doing the surgery ? What about SOT or any other new techniques, will they be suitable ?
    Any thoughts on why JT protocol (Fenbendzol) did not work ?

    1. Dear Pulse,

      Thank you for your comment.

      There are a lot of options discussed on this website, that I would consider. Please also find here some ideas: https://www.cancertreatmentsresearch.com/community/colon-cancer-colorectal-cancer/

      Here you will find some relevant case reports:
      https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/
      https://www.cancertreatmentsresearch.com/10-cases-of-complete-remission-from-stage-4-cancers-after-using-supplements-or-repurposed-drugs/

      Alternative to liver surgery may be TACE https://radiologie-uni-frankfurt.de/fuer_patienten/interventional_radiology/vascular_interventions/transarterial_percutaneous_chemoembolisation_tace/index_eng.html
      One of the best in the world in TACE is Prof. Thomas Vogl at Frankfurt University Hospital https://radiologie-uni-frankfurt.de/aerzte/index_ger.html
      The cost was usually 4000 euro per intervention and they used to require 4 interventions, one every month.

      I hope this helps.

      Kind regards,
      Daniel

  16. Thank you Daniel,

    Can you tell me something about doing SOT treatment for metastatic cancer.

    From the description of SOT on the RGCC website and also on some practitioners websites, it appears to be a very powerful tool and also it is the least invasive as compared to TACE or surgery. If it works as described, its use should be widespread.

    Are there any success stories from using SOT on solid tumor cancers.?
    Are there any practitioners whom you will recommend ?

    Thanks much.

    This website and all the efforts that you have put, to get this together for the cancer patient community is beyond commendable. I am new here and just read your story. I do not have words to praise your noble work. God bless you, you are a truly an amazing person.

  17. Dear Daniel, Johan and others who post great info, I would kindly ask for a bit of help.

    I am 41 years old. DX june 2020 stage 3 rectal cancer, 6 cycles of CAPOX + 22 radiations -> complete response placed on watch and wait no surgery. September 2021 PET CT recurrence in rectum and 6 lung mets scattered across all lungs.
    Nov 2021 1 cycle of CAPIRI and CETUXIMAB, stopped due to dysphagia and dysarthria
    Currently Capecitabine monotherapy, but I lowered the dose myself to 50% as I anyway lost all trust in chemo and barbaric treatments with drugs from 1980.. They declined surgery ablation or SBRT,.. So only chemo or nothing.
    I am MSS, no mutations
    My CEA and CA-19 are normal the whole time, so is my CRP and sedimentation.

    What I struggle with is which direction to go. There are just soo many things, supplements, off label drugs, various protocols, diets, baking soda, coloidal silver, methylene blue, red light therapy, mitochondrial correction,.. I believe in what you Daniel wrote, just pick one thing and do it right.

    Diet: Keto (Sigfried, Nasha Winters, Dom D Agostino, Paleomedicina.com), vs Plant based (grape cure, carrot cure, Gerson therapy)? They are the oposite. One is all fat, the other almost zero fat.. So which is it now? Ray Peat and Georgi Dinkov are all pro sugars and fruits and publish a lot of data showing fat is the main problem not demonisation of sugar as body anyway turns other sources to sugar. They say fasting + IF is just putting stress to the body, raising cortisol which raises stress response which is bad for cancer patient. Or is best low methinone diet to lower IGF-1? I think keto + chemo is gaining traction but again, just depends who you listen too.

    Jody Ledley tracks long term stage 4 cancer survivors and almost all (now already 100+) turned to some version of vegan diet. You can find her table in below link:

    https://onedrive.live.com/view.aspx?resid=88730FBC4617CB51%211031&ithint=file%2Cxlsx&authkey=%21AAalHPabxX-aeIA&sw=bypass

    A must read from Georgi Dinkov on below link, showing how fat is the main driver of cancer. And not even dietary fat as cancer just makes its own!! Acidosis (Warburg Effect) drives cancer through increased fat oxidation (Randle Cycle)

    http://haidut.me/?p=653

    Supplements: at one time I was taking like 70 caps a day, until you discover that most of that is not even absorbed. EGCG, genistein, reveratrol, berberine,. anything you look at has almost zero bioavailability.. They are not water soluble so I now take some of them dissolved in vodka or DMSO, but you cannot drink 5 dcl of vodka daily 😀 Off label drugs are a way to go then or liposomal supps, but still when you take such low doses of each one of them, what do you acomplish? None of it will kill cancer cells in that blood concentration. So would it no make more sense to maybe focus on 3-4 of them and take those in much higher quantity? Like bioavailable curcumin, milk thistle and quercetin and take 6 pills of each to try to reach higher concentration to make difference, or is anway all in vain?

    Ray Peat and some others say that poisoning cancer cells is anyway wrong strategy that did not work for 50 years and that we should focus on how to turn those cells back to healthy respiration. And some studies now target mitochondria. And reverting cells back to normal. That those cells are damaged and restoring respiration can stop and even turn cells back to normal which is probably the case with all spontanuous remissions.. As there are just so many stories without any supplements or drugs. Meditation, less stress, healthy food, exercise,.. On the other hand medicine only focus on cut, burn, poison.. Which of course damages healthy cells too and so many people then just die of chemo/radiation and related side effects.. I found studies showing people with CRC and lung, liver and other mets who denied treatmen live for 12-48 months.. When you check chemotherapy results it is not much better if that.. And the quality of life for chemo patient is much much worse too. So this is why I decline any more chemo as I dont care if it adds 6 months to my life if those 6 months will be spent in bed, throwing up, no sport ,no fun, no travel.. I do not have family so maybe my view is a bit more “egoistic”.. But for me quality is top priority..

    I started artemisenin which I dissolved in vodka to get some bioavailability as again in itself it is not water soluble. On the other hand studies show good results and I doubt those people took it in vodka. So how is it working then? With such low oral bioavailabilty?

    Jodi I mentioned above tracks people through various FB groups and told me there are almost no long term survivors doing Jane Mclelland protocol, she and maybe one or two more. Here we are talking years+ now having NED for a few months like I did.
    Same story with Joe Tippens. Worked for him, lots of ancetodal stories with fenben, but the one study they did with mebendazole showed progression in half and hyperprogression in others.. So much for fenben, meben..

    So all in all what should one do? I am thinking of reducing it down to taking low dose capecitabine and something to complement that with diet and some supps to avoid capecitabine resistance. But which diet and what supps? Combine with ivermectin, cycle with artemisenin, try to do it with mitohondrial correction approach so not trying to kill cancer cells but revert back to normal and restore respiration which is probably the case in all spontanuous remissions.. Baking soda? High dose apirin? Niacin? Melatonin?
    Or just give up trying to cure what is incurable and face the facts non of those things matter and only detract and make your life harder and loose more time with poppin pills all day long and counting fats or carbs or… 🙂

    Sorry for long post guys, I am just somehow lost and trying to do too many things..

    1. Hi Tomaz, sorry to hear about your health situation.

      Max Gerson cured his migraines with a diet consisting mainly of apples and then one of his patients said his skin tuberculosis disappeared with an apple diet. This set him on a lifelong journey of trying to treat disease with food mainly.

      Johanna Brandt cured cancer patients with a grape diet. Others cured cancer patients with herbs.

      Plants and fruits indeed appear to be powerful medicine.

      There’s no doubt a benefit in attempting to revert cancer cells back to healthy respiration. Melatonin is one option, for example.

      There might be a role for Metformin in cancer treatment but I agree it’s difficult to assess whether or not it is safe to use it. IMO only for short-term use, in the right combinations.

      Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus
      https://pubmed.ncbi.nlm.nih.gov/28656086/

      Phenylbutyrate is a glutamine inhibitor.https://journals.physiology.org/doi/full/10.1152/ajpendo.1998.274.5.E801

      Butyrate pretreated cells displayed a modulation of glutamine metabolism characterized by increased incorporation of carbons
      derived from glutamine into lipids and reduced lactate production.
      https://pubmed.ncbi.nlm.nih.gov/20715114/

      How is a supplement working when many studies showing very low or undetectable concentrations in blood?
      Probably in ways we do not understand yet. For example, it’s possible that the anticancer effects of curcumin are mostly indirectly through the effect it has on our microbiome. For example, via species that favor butyrate production.

      Often pleiotropic effects can lead to wrong conclusions.

      Look for synergies! For example valproic acid and capecitabine.

      Colon cancer and rectal cancer have similar features, expand your search to that type of cancer if you haven’t already.

      If you’ve read some of my postings here or on my blog you know I am not a fan of Jane Mclelland and Joe Tippens, to say the least,
      and I’m not surprised what Jody Ledley reports. I am glad someone is tracking this. It is sad though, so many are following the advice from Jane and Joe.

      I am going to read the article you posted, from Georgi Dinkov. Thanks for sharing, I will get back to you later.

      Best,

      Johan

      Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324161/

      Effect of Butyrate on Genetic Expression of Sirt1/AMPK and Akt/mTOR Axes in Murine Adipose Tissue
      http://researcherslinks.com/current-issues/Effect-Butyrate-GeneticExpression-Sirt1-AMPK/20/1/997/html
      *note the difference between oral and i.p.

      1. Hi Johan
        Interesting what you said about Jane McClelland and Joe Tippens protocol. My brother is very sick and I have gotten interested in the de-wormers, anti parasites and I am on the facebook group. However was afraid about the fenben because it doesn’t always work and since my brother has liver mets and ascites I didn’t want to suggest it and then his liver enzymes increase. Where is your blog I would like to read it. I also listen to Georgi Dinkov and Danny Roddy podcast interesting talks on there. But how to help someone is really difficult so many rabbit holes to go down

    2. I read the article by Georgi. A very plausible hypothesis b, and in many aspects very similar to what I have come to think.

      The thing is that with the current thinking and the way the pharmaceutical industry works it really sets us up for failure when you are dealing with a disease that needs different interventions concurrently, it leads to failure by design actually: let´s do A then B then wait then C, etc.

      So yes, consider glutamine and its inhibition. Estrogen, is another key player.

      But I wouldn´t go so far as to focus on metabolism entirely. In his article Georgi writes that “there is ZERO role for genes as a cause of cancer, and in fact mutations are now known to be a downstream effect of cancer.”

      That’s a very limiting belief. And a mistake IMO.

      You have to look at cancer from many different angles, including the use of chemotherapy which can be very effective, the problem is we use chemo as a standard protocol for certain types of cancers when it should be evaluated on an individual basis. Same for repurposed drugs.

    3. Dear Tomaz26,

      I will try to address quickly some of the points you made and questions:

      1. for lungs I would consider TACE to the lungs if needed
      2. There are any options with potential indeed, and that is good. I would look at the core treatment you are now using and build along that with the strategies that fit as I discussed in other posts. Next to that I will add some “lottery tickets” such as silver nanoparticles (easy to do at home) and cycles of antiparasitic drugs, changing them every 1-2 months
      3. some people succeed with Keto – personally I prefer the plant based diet, but both can be good if done correctly
      4. I checked the document of Jody Ledley – nice, but I cannot draw any conclusion since this is >50% anecdotes
      5. Better take the supplements with oils – however, supplements such a EGCG will be absorbed anyway at higher dose
      6. artemisinin with the whole plant will help the absorption – see studies referenced in my post on Arte
      7. the study done with Mebendaole has been designed wrong – pushing that huge dose in people with tumors such as liver mets will lead to very high dose of Mebendazole in the boood – at that level it works as chemo affecting bone marrow, liver toxicity and so on – see the article – they had to go out of the study – Mebendazole showed positive contribution to life at doses 10x smaller. So the study they preformed on Mebendazole was design to fail.
      8. Please read some of my posts carefully, and you will start to see the coherence – its important to understand – the best is to ask for ideas to maximize the chance of successful outcome after we decided which way we go

      Kind regards,
      Daniel

  18. Regarding ” just pick one thing and do it right.”. This makes a lot of sense, and I would apply this BUT be very flexible and adjust quickly. In trading, they say that if you want to be a good trader, don’t marry your trades. I think the same applies here when trying to deal with one’s cancer. Be ready with different options so as to be able to quickly move to another.

  19. Tomaz, I know that with cancer it can sometimes feel so desperate. I hope the below can cheer you up.
    All of these urls present some of the most powerful anti-cancer treatments that I am aware of.

    url 1: This one treated a patient with no lung reserve with 3-BP. The 3-BP knocked down his LDH levels by ~50% –then they treated with combination 3-BP and paracetamol — LDH went to 0?

    url 2: This one is a mouse treatment with formulated 3-BP as cyclo-dextrin 3-BP (~sugar 3-BP, not that hard to synthesize). The mice with pancreatic cancer had large responses. This formulation appears to be nearing the clinic.

    url 3: This used minicells. Minicells can load up chemotherapy and deliver it directly to cancer cells. This approach in mice was upwards of 1 million times more powerful than straight chemo. This is now in human clinical trials and one could imagine that this could be very powerful when combined with many other treatments.

    urls 4: Nano-methyglyoxal. Basically, honey wrapped in a shrimp shell; the shell melts when it arrives at the cancer cell and releases the MG. This had very large effects in mice and was magnified when it was combined with vitamin C etc. .

    https://pubmed.ncbi.nlm.nih.gov/24636230/
    https://pubmed.ncbi.nlm.nih.gov/25326230/
    https://pubmed.ncbi.nlm.nih.gov/17482133/
    https://pubmed.ncbi.nlm.nih.gov/25999714/

    I hope this helped to cheer you up! There are some very powerful anti-cancer treatments. Sometimes it can be as simple as properly formulating a natural substance such as MG that then can become very powerful. If you had some reach into a lab, there could be many very powerful treatments that would open up for you. You could get away from the problem of low bioavailability and often toxic side effects.

    Best Wishes, Jcancom

  20. Thank you very much Johan, Daniel, Jcancom. I will go through replies in detail and implement some more things and let you know if any question pops up. Its really good to know one is not alone fighting this terrible disease so thanks again for taking your time to reply.
    Johan: really nice blog. Now you gave me a material for some more hours to study that too 😀

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