Pyrvinium Pamoate: An Anti Worm Drug with Important Anti Cancer Potential

Summary: Pyrvinium Pamoate (PP) (a quinoline-derived cyanine dye) is an relatively non toxic anthelmintic drug, FDA-approved, sold over the counter in countries like Sweden, Norway, Denmark used to treat pinworms in humans and animals. During the recent years this compound has been shown to effectively inhibit various cancer cells types such as brain, colon/colorectal, breast, prostate, etc. and
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Cancer addiction to Cyst(e)ine & Lowering Glutathione inside cancer cells

Recently, I came across this nice article (Ref) which is in turn based on a recent publication (Ref.) arguing that in some types of renal cancer cells, cystine deprivation “presents an attractive therapeutic opportunity that may bypass the apoptosis-evading mechanisms characteristic of drug-resistant tumor cells.” However, as we will see Cysteine is relevant not only in renal cancer but in most of
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Another weak spot of cancer cells: ATP citrate lyase inhibition

ATP citrate lyase is an important enzyme for he fast dividing cancer cells ATP citrate lyase (ACL or ACLY) is an intracellular enzyme (located in cytosol) responsible for the conversion of citrate that comes out of the mitochondria,  to acetyl-CoA and oxaloacetate. ATP citrate lyase is primarily expressed in lipogenic tissues. Other vegetative tissues express little to
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When cancer is deprived of essential nutrients Acetate is the fuel

Glucose is one of the principal fuels when it comes to cancer cells. More recently it has become clear that other fuel sources, including glutamine, lipids, and protein also play an important role in cancer. However, I was not aware about the relevance of acetate as a fuel for cancer cells. Indeed, while acetate can
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Phlorizin & Phloretin: a powerfull glucose transport inhibitor

Summary  I know and like Phloretin since long time ago but today I came across a very interesting (old) patent that is based on Phlorizin (a derivative of Phloretin) as an anti cancer treatment. Based on the science behind, safety and case reports, I think this is very interesting and below I will share the information
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Gelum Drops: reducing lactic acid, increasing hemoglobin and lymphocytes

This is a German product that has been recommended to me by a German friend (Thank you!) and though I should share that with all the readers. So here it is her e-mail: “Just wanted to give you some information about a product, which you can share also with others (if you like). A natural
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Phosphoethanolamine & Meclizine: inhibiting an enzyme required to form the building blocks of membranes

Summary Actually, the title (inhibiting an enzyme required to form the building blocks of membranes) refers to Meclizine since as we will shortly discuss below, Phosphoethanolamine acts (probably) on mitochondria. The compound, Phosphoethanolamine, has been shown to kill tumor cells (A. K. Ferreira et al. Anticancer Res.32, 95€“104; 2012) at the University of S£o Paulo in Brazil. As a result some
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Potential solutions against Cachexia: Glutaminolysis inhibitors and more

Conclusion To avoid cachexia we need to reduce the request for glutamine via lactate (see the seven points below) and in order to kill cancer cells relying on glutamine we should reduce/inhibit glutaminolysis (e.g. EGCG), reduce glutamine transport (retinoic acid), reduce blood glutamine (phenylbutyrate and avoid (red) meet). Background Cachexia is loss of weight, muscle
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Diflunisal

CAS 22494-42-4 My opinion: An anti-cancer treatment with great potential relevant for most types of cancers visible on PET/CT. Regarding its effectiveness, this statements says it all: “33 patients were evaluable for metric response, 20 for metabolic and 19 for tumor marker response assessment. For tumor marker follow up 11 % had a CR, 53 %
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3 Bromopyruvate

Other names: 3BP, 3-Bromopyruvic Acid CAS number:1113-59-3 Source: The info shared here came from multiple directions. That includes literature research, personal experience, a lot of ideas discussed and shared on Cancer Compass, discussion with a good number of professors and doctors, discussion with German clinics, discussions with patients. My opinion: For an update on my
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