Background: Propranolol is a drug commonly used to treat high blood pressure, irregular heart rhythms, pheochromocytoma (tumor on a small gland near the kidneys), certain types of tremor, and hypertrophic subaortic stenosis (a heart muscle disease). It is also used to prevent angina (chest pain), migraine headaches, and to improve survival after a heart
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Category: Metabolic inhibitors
Most cancer cells (~97%) predominantly produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol rather than by a lower rate of glycolysis followed by oxidation of pyruvate in mitochondria as in most normal cells. The latter process is aerobic (uses oxygen). Malignant, rapidly growing tumor cells typically have glycolytic rates up to 200 times higher than those of their normal tissues of origin; this occurs even if oxygen is plentiful. Otto Warburg postulated this change in metabolism is the fundamental cause of cancer. Recently, this view regained momentum and intensive academic research has uncovered several metabolic inhibitors (e.g. glycolysis inhibitors) with high potential as anti cancer drugs. The stong point of this anti cancer approach is that (in contrast to the genetic approach) metabolic inhibitors are relevant for most types of cancers.
Quercetin: even more anti-cancer potential than Curcumin?
How I learned about Quercetin’s potential: Sometime ago I had access to a number of chemosensitivity test results and performed some analysis on them. These chemosensitivity tests are performed by specialized laboratories and essentially consists in collecting blood from patients, capturing the circulating tumor cells and then exposing these tumor cells to various chemicals in
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Hippo Pathway: Regulating Organ Size & Cell Proliferation
Background and Mechanism: Interestingly, a few years ago it has been published in Nature magazine a study reporting that glucose, the main energy source used for energy generation in cells, regulates the Hippo pathway (specifically its downstream effector YAP)(Ref.). This is very interesting and ground breaking because with this research it has been indicated for the first time
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pH in Cancer & Tumor Acidification: A Top Treatment Strategy
Summary: pH and Cancer is an intensively discussed subject both in the alternative treatment arena and fortunately more and more in the scientific arena. In terms of treatments, when we speak about pH in cancer I am thinking of treatments involving e.g. the well known Sodium Bicarbonate, Cesium Chloride, Germanium, etc. I am also thinking of diets such
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A few words on Monocarboxylate transporters and their relevance in cancer
Here we have a new and very good article on MCTs: Monocarboxylate transporters in the brain and in cancer It explains the role of MCTs in normal and cancer cells and an important point is related to the fact that although MCT1 has the highest affinity to lactate all MCTs (from MCT1 to MCT4) can both
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Pyrvinium Pamoate: An Anti Worm Drug with Important Anti Cancer Potential
Summary: Pyrvinium Pamoate (PP) (a quinoline-derived cyanine dye) is an relatively non toxic anthelmintic drug, FDA-approved, sold over the counter in countries like Sweden, Norway, Denmark used to treat pinworms in humans and animals. During the recent years this compound has been shown to effectively inhibit various cancer cells types such as brain, colon/colorectal, breast, prostate, etc. and
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Cancer addiction to Cyst(e)ine & Lowering Glutathione inside cancer cells
Recently, I came across this nice article (Ref) which is in turn based on a recent publication (Ref.) arguing that in some types of renal cancer cells, cystine deprivation “presents an attractive therapeutic opportunity that may bypass the apoptosis-evading mechanisms characteristic of drug-resistant tumor cells.” However, as we will see Cysteine is relevant not only in renal cancer but in most of
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Another weak spot of cancer cells: ATP citrate lyase inhibition
ATP citrate lyase is an important enzyme for he fast dividing cancer cells ATP citrate lyase (ACL or ACLY) is an intracellular enzyme (located in cytosol) responsible for the conversion of citrate that comes out of the mitochondria, to acetyl-CoA and oxaloacetate. ATP citrate lyase is primarily expressed in lipogenic tissues. Other vegetative tissues express little to
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When cancer is deprived of essential nutrients Acetate is the fuel
Glucose is one of the principal fuels when it comes to cancer cells. More recently it has become clear that other fuel sources, including glutamine, lipids, and protein also play an important role in cancer. However, I was not aware about the relevance of acetate as a fuel for cancer cells. Indeed, while acetate can
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Phlorizin & Phloretin: a powerfull glucose transport inhibitor
Summary I know and like Phloretin since long time ago but today I came across a very interesting (old) patent that is based on Phlorizin (a derivative of Phloretin) as an anti cancer treatment. Based on the science behind, safety and case reports, I think this is very interesting and below I will share the information
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Some thoughts on 3BP
During the past days I was “forced” to go back to 3BP and think more about it in the context in which I hear more and more about people who are responding but even more important people not responding (out of which some very good friends …). Actually, when I hear about patients/friends not responding
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Gelum Drops: reducing lactic acid, increasing hemoglobin and lymphocytes
This is a German product that has been recommended to me by a German friend (Thank you!) and though I should share that with all the readers. So here it is her e-mail: “Just wanted to give you some information about a product, which you can share also with others (if you like). A natural
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Phosphoethanolamine & Meclizine: inhibiting an enzyme required to form the building blocks of membranes
Summary Actually, the title (inhibiting an enzyme required to form the building blocks of membranes) refers to Meclizine since as we will shortly discuss below, Phosphoethanolamine acts (probably) on mitochondria. The compound, Phosphoethanolamine, has been shown to kill tumor cells (A. K. Ferreira et al. Anticancer Res.32, 95€“104; 2012) at the University of S£o Paulo in Brazil. As a result some
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Potential solutions against Cachexia: Glutaminolysis inhibitors and more
Conclusion To avoid cachexia we need to reduce the request for glutamine via lactate (see the seven points below) and in order to kill cancer cells relying on glutamine we should reduce/inhibit glutaminolysis (e.g. EGCG), reduce glutamine transport (retinoic acid), reduce blood glutamine (phenylbutyrate and avoid (red) meet). Background Cachexia is loss of weight, muscle
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2-DeoxyGlucose (2-DG)
Summary: This is a glucose analog that is avidly taken up by cancer cells. DeoxyGlucose (2DG) differs from normal glucose only by removal of an oxygen atom from the hydroxyl group at the 2 position. 2DG is one of the most relevant glycolysis inhibitor. Since it is a glycolysis inhibitor, it is relevant to all cancers visible on PET
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Diflunisal
CAS 22494-42-4 My opinion: An anti-cancer treatment with great potential relevant for most types of cancers visible on PET/CT. Regarding its effectiveness, this statements says it all: “33 patients were evaluable for metric response, 20 for metabolic and 19 for tumor marker response assessment. For tumor marker follow up 11 % had a CR, 53 %
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Discussion with Dr. Jason Williams
Dear Friends, Following our discussion on Cancer Compass, Dr. Jason shared with usrelevant information related to 3BP treatments and next to that some more info on Salinomycin and new treatments he is currently using with very good results. Jason R. Williams, MD is a board certified Radiologist who specializes in the diagnosis of conditions using
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3 Bromopyruvate
Author: Daniel S, PhD; Last update: April, 2021 Other names: 3BP, 3-Bromopyruvic Acid CAS number:1113-59-3 Source: The info shared here came from multiple directions. That includes literature research, personal experience, a lot of ideas discussed and shared on Cancer Compass, discussion with a good number of professors and doctors, discussion with German clinics, discussions with
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