This post is related to a man from Europe, JG, with whom I am in contact since May 2018, and his successful treatment of an aggressive form of Stage IV sarcoma.
A week ago, JG contacted me to share some very good news, as he is now at a point where there is no more evidence of disease. He specifically asked me to share his story but also keep his identity confidential, which is what I am going to do here. He would like to share his story in order “to give hope and help to other people suffering from this disease”.
Here is JG’s short report received during December 2018:
“I am JG, I am 26 years old and I had a sarcoma, grade III, stage IV in mediastinum (several tumors). I followed a surgery and several complementary treatments such us:
- 2 DG metronomic
- Low carb diet
- Oncothermia & radiation
- Suplements: melatonin, Vit D3, probiotics, prebiotics, honokiol, HCA
- Drugs: cimetidine, celecoxib, ciclofosfamide, mebendazol, lovastatin. These have been changed over the time, but I write the most important here. I don’t know if it a good idea because I assumed several interactions in order to try to kill microscopic disease, other people should be aware of this interactions.
The results from the last MRI showed no evidence of disease although the surgical resection was not complete.“
It may be relevant to mention here that JG has a medical doctor training, which helped him to easier navigate through various treatment options. While I cannot share more details here, the only point I can make is that the past and present of JG is very impressive. That can be summarized in a few words: A challenging life turned into success for himself and others. And JG is only 26 years old. I am sure those results will continue, and it’s great to meet such people.
I do realize that the report above may be a little too short. Therefore, in order for the reader to have a more clear understanding of the context for the results mentioned above, I will also share with you small parts of our (extensive) e-mail conversation. However, at the same time I will keep confidential any personal data from JG.
JG contacted me via e-mail, writing the following:
“Hello, My name is JG and I have been following your website since I was diagnosed a very rare and aggressive type of sarcoma. It was controlled but recently it has losed all control and it has metastasized to the chest wall. I know you cannot give precise advice etc, but your opinion is too important for me. I have been managing my own treatment and I will continue doing the same. I will expose briefly what I think could be a good strategy to start as quick as possible, and i would be really grated if you can give me your opinion.
– Ketogenic Diet – 2DG and vit C infusions
– Ozone / Hiperbaric oxigen
– Oncothermia or Nanothermia applied to the lessions
– Cocktail: Cimetidine, Heparin, Mebendazole, Ciclophosfamide, Metformin, DCA, Lovastatin, Doxyciclin, Hydroxycloroquine, Tranilast
after several e-mails exchanged between the two of us, JG writes:
“… After talking with the Surgeon I have decided to operate the main tumors ( 3 ), located in the chest wall. It seems they could be removed completely, and with that surgery they would remain 2 little nodules of 1 cm approx in the thorax ( which are not going to be removed ). So now it is really important for me designing a strong anti recurrence protocol in order to avoid recurrence after the surgery. The measures and drugs i have planned using are:
pre operation: Heparin, cimetidine, MCP, Celecoxib, Diclofenac, Propranolol, Hydroxichloroquine, Viscum album, PSK, Silimarine, Curcumine, Garlic, Cruciferous extract, Lactoferrin, EGCG, AHCC, Fish oil, Filgrastim/neupogenmaybe ? (not sure about this). Of course I will cut off all the drugs that cannot be used pre surgery some days before the surgery, such us heparin.
peri operation: ketorolac (following the videoinstructions)
post operation: Same drugs and supplements used pre operation ; Vit C IV( 3 times / week); 2 DG protocol; Metronomic chemotherapy: ciclophosphamide, etoposide ; Local Hiperthermia in the places where the tumors were growing and in the two nodules that are not going to be removed surgically.
following a question from JG on approaches to reduce the chance for recurrence after surgery (besides addressing inflammation in general) here is a part of my response which I share as it may inspire other people, and/or trigger discussions:
“… Regarding ways to support radiotherapy/chemotherapy while reducing chance for recurrence, I think there are several major lines that should be addressed:
1. Increase immune system effectiveness and reduce pro-growth tumor environment.
It is known that radiotherapy/chemo may trigger necrosis of tumor cells that in turn may trigger immune reactions. Sometimes the immune reactions following radiotheraphy/chemo can be so large that would lead to an abscopal effect, where tumors in other parts of the body can also be wiped out after radiotheraphy to a single spot. In order to increase the chance for such reactions and reduce chance for reccurence, we need to maximize the effectiveness of the immune system to the best of our knowledge.
For this, I would consider some of the following:
a. Reducing T-regs, M2, and MDSC
– low dose Cyclophosmamide to reduce T- regulatory cells https://www.ncbi.nlm.nih.gov/pubmed/22761338
– Cimetidine may also reduce T-regs https://ecancer.org/journal/8/full/485-repurposing-drugs-in-oncology-redo-cimetidine-as-an-anti-cancer-agent.php
– M1 macrophages, protect against infection and can work to destroy tumours, and M2 macrophages promote wound-healing and have been linked to tumour growth and spread. So we want to target and block the accumulation of M2 cells in tumours after radiotheraphy. Doxycicline is an inhibitor of the M2 https://www.ncbi.nlm.nih.gov/pubmed/24505138 Cyclooxygenase-2 Inhibition also Blocks M2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646746/ this is why Aspirin or Celecoxib may help here but also in general to reduce the chance of metastasis. There is one more drug here very good, but difficult to get as it is very expensive (Plerixafor) https://www.cancertreatmentsresearch.com/plerixafor-mozobil/
– MDSC also need to be inhibited. Retinoic acid and Vitamin D3 could help on this line https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019895/ Cimetidine will also help here https://www.cancertreatmentsresearch.com/antihistamine/ Tadalafil can also reduce MDSC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329916/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931815/
Phosphodiesterase-5 inhibition reduces postoperative metastatic disease by targeting surgery-induced myeloid derived suppressor cell-dependent inhibition of Natural Killer cell cytotoxicity https://www.societederecherchesurlecancer.ca/en/news/drug-repurposing-viagra-and-agriflu-help-to-fight-cancer Pharmacological inhibition of COX-2 blocks ARG-1 expression in MDSC and prevents the local and systemic expansion of MDSCs, leading to a lymphocyte-mediated antitumor response (Ref.). Therefore, Celecoxib could be a good option here.
– Histamine inhibition by Cimetidine and Cetirizine https://www.cancertreatmentsresearch.com/antihistamine/
b. Increasing the activity of T-cells via supplements such as Coriolus
c. Increasing the chance of effectiveness of T-cells by re-balancing the PH around the tumors with alkalizing approaches such as Basentabs or proton pump inhibitors (should not be used with weak-acidic chemotherapy – only with those weak-basic)
d. Reduceing fibroblasts using anti-fibrotic agents (nonsteroidal anti-inflammatory drugs [NSAIDs] or tranilast) that should also reduce the infiltration of tumors with immunosuppressive cells (regulatory T cells and myeloid-derived suppressor cells) https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.12584
2. Reduce HA with 4-MUhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369655/ in order to reduce inflammation and create a tumor micro-environment that is easily addressable by drugs such as chemo therapies. I would use this only in combination with major treatments such as chemo, etc. If no major treatments are used, could be better not to use 4-MU as HA may create a temporarily slower tumor growth https://www.cancertreatmentsresearch.com/the-hyaluronic-acid-cage-to-open-or-not-to-open/
3. Increase Tumor oxygenation via e.g. – local hyperthermia prior to and after radiotheraphy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357106/– using Niacin supplement prior to radiation and drinking some coffee prior to radiation. The above reference discuses in entire strategy focused on “Targeting Tumor Perfusion and Oxygenation to Improve the Outcome of Anticancer Therapy”
4. Decrease intracellular PH in cancer cells via proton pump inhibitors and hyperthermia
The above would be a strategy to support major therapies and/or to reduce chance for recurrence. “Major treatments” are a different discussion that we touched in some e-mail exchange we already had. By major treatments, I am thinking of treatments that directly and strongly attack cancer cells. Those include, chemo, radio, new treatments (such as 2DG, 3BP, Salinomycin, Diflunisal, etc).
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