Relevant drugs/supplements/protocols for brain cancer:
- cusp9 protocol (Ref.)
- Chlorimipramine, the keto diet and Boswellic Acid
- Noscapine inhibits tumor growth in TMZ-resistant gliomas http://www.ncbi.nlm.nih.gov/pubmed/21925789
- Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas http://www.ncbi.nlm.nih.gov/pubmed/25542083
- Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy http://www.ncbi.nlm.nih.gov/pubmed/25434381
- Tetanus Vaccine Boosts Cancer Therapy http://www.nbcnews.com/health/cancer/tetanus-vaccine-boosts-cancer-therapy-n321596
- Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. http://www.ncbi.nlm.nih.gov/pubmed/24505127
- Antagonist drug Emend halts brain tumor growth http://www.news-medical.net/news/20130320/Antagonist-drug-Emend-halts-brain-tumor-growth.aspx
- Canadian researchers break blood-brain barrier with new ultrasound treatment http://www.ctvnews.ca/health/canadian-researchers-break-blood-brain-barrier-with-new-ultrasound-treatment-1.2648878
- Blood glutamate scavengers (Oxaloacetate) prolong the survival of rats and mice with brain-implanted gliomas. http://www.ncbi.nlm.nih.gov/pubmed/22297683 Glutamate transporters in the biology of malignant gliomas. http://www.ncbi.nlm.nih.gov/pubmed/24281762
- Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate. http://www.ncbi.nlm.nih.gov/pubmed/12241121/
- ECCT http://www.
- Dendritic Cells + NDV http://www.
- POH https://www.cancertreatmentsresearch.com/?p=602
- Treating brain tumours with traditional Chinese medicine https://www.fau.eu/2016/02/02/news/research/treating-brain-tumours-with-traditional-chinese-medicine/ Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential http://www.nature.com/articles/srep19799 (from venom of Chinese golden scorpion)
- Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice.
Eradication of experimental brain metastases of human non-small cell lung cancer by macitentan, a dual antagonist of the endothelin A and B receptor, combined with paclitaxel. http://meetinglibrary.asco.org/content/103362-127
N ote: One box containing Opsumit (macitentan) 10mg film coated tablets, 30 tablets per box. Price £2306.00 per box (Ref) Alternatively, it may be found in China (CAS 441798-33-0)
- Pyrvinium Pamoate: targets CD133 in human glioblastoma brain tumor-initiating cells http://www.ncbi.nlm.nih.gov/pubmed/26152745
Pyrvinium pamoate – 5 mg/kg/day – (an Anthelmintic drug over the counter in countries like Sweden, Norway, etc.)
- “Since IL-8 is clearly upregulated in glioblastoma and contributes to the fl orid angiogenesis of that disease, and since interference with IL-8 function has been shown to inhibit glioblastoma invasion and growth in several experimental models, and dapsone has been repeatedly been shown to clinically inhibit IL-8 function when used to treat human neutrophilic dermatoses, we believe that dapsone thereby reduces seizures by countering IL-8 function and may similarly retard glioblastoma growth by such anti-IL-8 function.” https://www.researchgate.net/file.PostFileLoader.html?id=56b7358d5cd9e3cd3f8b457e&assetKey=AS%3A326467700445185%401454847373596
- Researchers have demonstrated for the first time that it is possible to inhibit the growth of brain tumors by treating the common Cytomegalovirus (CMV) https://www.sciencedaily.com/releases/2011/09/110927072612.htm
- celecoxib: Both glioblastomas and medulloblastomas express high levels of cyclooxygenase-2 (COX-2) that catalyzes conversion of arachidonic acid to prostaglandins and other eicosanoids with concomitant secretion of proinflammatory prostaglandin E2 (PGE2)[64–66]. In gliomas, the level of COX-2 expression is directly correlated to glioma grade and associated with shorter survival in glioblastoma patients. Non-steroidal anti-inflammatory drugs, capable of inhibiting cyclooxygenase, significantly suppress the growth of glioblastoma and medulloblastoma in preclinical models[9,64,66]. Also, short-term use (< 10 years) of anti-inflammatory medication is associated with a protective effect against glioblastoma http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308527/
- Prazosin https://www.sciencedaily.com/releases/2016/04/160421085706.htm
Most of the above are accessible to anyone in terms of price and availability.
Based on my readings so far, it becomes apparent that intracellular Cl modulation is a way to target GMB. Drugs or supplements that can modulate Cl channels are:
- Metformin – Metformin impairs the chloride current directly interacting with the extracellular portion of CLIC1 (chloride intracellular channel 1 – a transiently active channel essential for GBM growth). Reference: Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=2617
Indeed, here is a scientific article showing good potential of Metformin against GBM and even more when combined with DCA or TMZ https://www.omicsonline.org/individualizing-chemotherapy-using-the-antidiabetic-drug-metformin-as-an-adjuvant-1948-5956.1000197.pdf
- Scorpion venom
- Lansoprazole and possibly Omeprazole seem to also inhibit chloride channels http://www.ncbi.nlm.nih.gov/pubmed/10711360
Other relevant references:
- Treatment Options for Glioblastoma and other Gliomas http://virtualtrials.com/williamsTreatmentOptions2015.pdf
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