Summary Actually, the title (inhibiting an enzyme required to form the building blocks of membranes) refers to Meclizine since as we will shortly discuss below, Phosphoethanolamine acts (probably) on mitochondria. The compound, Phosphoethanolamine, has been shown to kill tumor cells (A. K. Ferreira et al. Anticancer Res.32, 95€“104; 2012) at the University of S£o Paulo in Brazil. As a result some
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Author: Daniel
Anti cancer drugs and supplements
Below is a piece of a recent nice article proposing a broad-spectrum integrative approach for cancer prevention and treatment. I find it interesting specifically because the article is suggesting a large list of drugs and supplements that are easy to access while addressing multiple anti cancer mechanisms. The article is entitled: Designing a broad-spectrum integrative approach for cancer
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Dendritic Cell therapy & Supporting Strategies
Update on April 2016: I do not see this option as a top option anymore given that I heard many actually starting to progress after starting this therapy. It is not only one person but several so a pattern starts to occur. Note that DC is typically given with New Castle Disease Virus – so I
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Chloroquine & Hydroxychloroquine: supporting chemo effectiveness and more
Summary Chloroquine is an anti-malarial drug available at pharmacies for people travelling to area with malaria risks as well as to address other health challenges. Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested.
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Perillyl Alcohol (POH) for brain tumors via nasal spray
Summary A less known but very effective natural anti cancer element, Perillyl alcohol is isolated from the essential oils of several plants including citrus, cherries, lavender, peppermint, spearmint, celery seeds, sage, cranberries, lemongrass, ginger grass, etc. Accessible at Medicor (see below) or it can be ordered from chemical suppliers under the CAS 18457-55-1. Oral administration has lead
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Gut bacteria amplifies immunotherapy: the power of Probiotics
Today, I came across this very interesting news, adding support to a fast growing amount of knowledge suggesting a strong connection between gut bacteria and the immune system: Gut bacteria can dramatically amplify cancer immunotherapy “Introducing certain bacteria into the digestive tracts of mice with melanoma can help their immune systems attack tumor cells. The gains were
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Potential solutions against Cachexia: Glutaminolysis inhibitors and more
Conclusion To avoid cachexia we need to reduce the request for glutamine via lactate (see the seven points below) and in order to kill cancer cells relying on glutamine we should reduce/inhibit glutaminolysis (e.g. EGCG), reduce glutamine transport (retinoic acid), reduce blood glutamine (phenylbutyrate and avoid (red) meet). Background Cachexia is loss of weight, muscle
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If you are using a mobile device to access this website
If you are using a mobile devices to see this website, I suggest to scroll down to the bottom of the page and in the left side-bottom click on “web”. In this way you will switch to a format that allows you to see all the navigation options of this website and as a result
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ImmunoMax: a low cost immuno simulating vaccine
Summary A plant derived activator of natural killer cells (NK) at 2-3 hours after the injection. It is claimed that cytolytic capacity of NK cells is increased 3-fold after activation with Immunomax. Produced and registered in Russia for use as an antiviral pharmaceutical. It can be bought in small vials ready for injection and is administrated as an intramuscular injection.
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Modulating free radical production with low level magnetic fields
The following article is a nice one indicating that simply placing magnets on your body may lead to modulation of ROS production in cancer cells. Modulation of Hydrogen Peroxide Production in Cellular Systems by Low Level Magnetic Fields Increased generation of reactive oxygen species (ROS) and an altered redox status have long been observed in
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2-DeoxyGlucose (2-DG)
Summary: This is a glucose analog that is avidly taken up by cancer cells. DeoxyGlucose (2DG) differs from normal glucose only by removal of an oxygen atom from the hydroxyl group at the 2 position. 2DG is one of the most relevant glycolysis inhibitor. Since it is a glycolysis inhibitor, it is relevant to all cancers visible on PET
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Anti PD-1 and anti PD-L1 Immunotherapies
Summary: A very new and promising immunotherapy approach to the treatment of cancer is the use of immune checkpoint inhibitors. These treatments work by “taking the brakes off” the immune system, so that the immune system becomes more effective in attack against cancer. Several different types of checkpoint inhibitors, targeting different checkpoints or “brakes” on immune
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Antihistamine to reverse immunosuppressive mechanism in cancer
Histamine is produced in the human body by some of the white blood cells called basophils, eosinophils, and by mast cells found especially numerous at sites of potential injury €” the nose, mouth, and feet, internal body surfaces, and blood vessels. Its role is to increase the permeability of the capillaries to white blood cells and some proteins, to
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GnRH agonists and antagonists
My opinion: Besides the typical usage in hormone dependent cancers (e.g. prostate, ovarian and breast cancer) to inhibit testosterone or estrogen production, this is a very relevant drug with large anti cancer potential in many other types of cancers. This is because many cancer cells have GnRH receptors. When using the GnRH agonist or antagonists,
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Huachansu Zhusheye (Bufalin)
Summary: Somehow I have a very good feeling about this one. I came to this component via research on cardiac glycosides (CG). One of the main active ingredient in Huachansu Zhusheye is Bufalin which is a cardiac glycoside. Huachansu Zhusheye is a Chinese medicine that can be administrated both orally or IV and is accessible
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Ultra low dose Taxol
Summary This is a very interesting, accessible and low cost therapy focused on immune system modulation and anti angiogenesis effects. It can be used in parallel with therapies directly targeting cancer cells such as 3BP, Salinomycin, etc. In addition it can be used in combination with immunotheraphies such as Dendritic cells. Indeed it has been
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Autoimmune disease & Quercetin
Autoimmune disease is aabnormal immune response of the body against substances and tissues normally present in the body. In other words the immune system starts attacking healthy parts of the body. I decided to shortly write about thisdisease since it is a potential side effect following treatments with immunotherapies such as DendriticCells or anti PD1/PDL1
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Pancreatic Cancer
The list below will be continuously updated. Alpha-lipoic acid + low-dose naltrexone: Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. http://www.ncbi.nlm.nih.gov/pubmed/20042414 Dipyridamole Chloroquine see also my post on Chloroquine. Biological Approaches to Therapy of Pancreatic Cancer http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882228/ A triple combination of atorvastatin, celecoxib
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A fit for ketogenic diet
One short but important point: for cancers with no or limited mitochondria use ketogenic diet. That will be very effective. Why? The cancer cells will not be able to switch on fuels other than glucose. ccRCC seems to be a cancer characterized by low to no mitochondria.
Diflunisal
CAS 22494-42-4 My opinion: An anti-cancer treatment with great potential relevant for most types of cancers visible on PET/CT. Regarding its effectiveness, this statements says it all: “33 patients were evaluable for metric response, 20 for metabolic and 19 for tumor marker response assessment. For tumor marker follow up 11 % had a CR, 53 %
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