Another weak spot of cancer cells: ATP citrate lyase inhibition

ATP citrate lyase is an important enzyme for he fast dividing cancer cells ATP citrate lyase (ACL or ACLY) is an intracellular enzyme (located in cytosol) responsible for the conversion of citrate that comes out of the mitochondria,  to acetyl-CoA and oxaloacetate. ATP citrate lyase is primarily expressed in lipogenic tissues. Other vegetative tissues express little to … Continue reading Another weak spot of cancer cells: ATP citrate lyase inhibition