Anti Psoriasis Drug Works Against Tumors

Background: A recent press release from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) discuss the results of German researchers who demonstrated that dimethyl fumarate (DMF), a drug used to treat Psoriasis patients can also help in the fight against cancer. This study has been performed on lymphomas and DMF appears to have at least comparable effectiveness and is better
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Serotonin Makes Tumors Happy Too

Serotonin and its Role: Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system of humans. Serotonin is manufactured in the brain (dorsal raphe nucleus cells, which are located deep in the brain) and the intestines and is primarily stored in and transported by
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CRM197: An Anti Cancer Vaccine Discovered in Italy

Background: I came across this treatment route a few years ago and I had and still have a very good feeling about it. So, I thought it may help to increase the awareness if I share here a bit about it: CRM197 (cross-reacting material 197) is a non-toxic form of diphtheria toxin. Diphtheria is an infection caused by
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Itraconazole: An Antifungal Drug With Anti Cancer Properties

Background: Itraconazole is a FDA approved drug, developed as an orally administrated antifungal drug, and has been used clinically for many decades with a well-established safety record. It has been used in the prevention and treatment of a broad range of fungal infections, such as aspergillosis, blastomycosis, candidiasis, histoplasmosis, but also in various dermatological and nail infections. Since
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The Immune System Fights Cancer as a Metabolic Disease

Background: Scientists at the University Hospital and the DKFZ in Heidelberg, Germany have discovered that a protein from immune cells paralyzes the energy supply in tumor cells. The German Society of Pathology has awarded them with the Novartis Prize. The scientists have recently published their findings in Nature Communications. (Ref.) Mechanism: Natural killer cells “patrol”
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Maraviroc: An anti-HIV Drug that Reactivates the Immune System to Fight Cancer

Introduction: Recently, with the help of a reader of this website (Thank you, Jose!), I came across a very relevant article, Immunotherapy in metastatic colorectal cancer for the first time utilizes the innate immune system, published on the website of the German Cancer Consortium (DKTK). This article describes the results of a recent clinical trial running in Heidelberg, Germany using an
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Omega-3 Fatty Acids, Budwig Diet & their Antitumor Activity

Summary: This is a long post so here is a short summary: Omega-3 fatty acids have anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. Because Omega-3 fatty acids are pushing out of the cancer cells the glutathione much needed for the cancer cell survival, Omega-3 fatty acids can be also combined with chemo and with that increase or enable chemo
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Citric Acid Inhibits Fermentation and Kills Cancer in Humans

Background:  Citric acid exists in large amounts in a variety of fruits and vegetables, most notably citrus fruits and was first time isolated from lemon juice.  Its salt form, Citrate, is an intermediate in the citric acid cycle (also called TCA cycle, TriCarboxylic Acid cycle, Krebs cycle, Szent-Györgyi – Krebs cycle), a central metabolic pathway for animals, plants and
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High Dose Vitamin C & Cancer

Background: L-ascorbic acid (C6H8O6), known as Vitamin C, has a variety of functions in humans, some of which are not yet fully understood. It was discovered in 1930 by Albert Szent-Györgyi (Hungarian, half Romanian by descent), who as a result of this discovery received  Nobel Prize in Physiology or Medicine in 1937. Note, that Albert Szent-Györgyi is the same scientist
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Creatine: Counteracts Cachexia and Supports Methylglyoxal

Background: Creatine  is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle. It is produced in the human body from the amino acids glycine and arginine. Creatine supplements are widely used by athletes, bodybuilders, wrestlers, sprinters, and others who wish to gain muscle mass,
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Plerixafor: Exposing Hidden Enemies & Cimetidine: Not Letting Them Hide

In an article published on May 25, 2016 in Science Translational Medicine, the researchers discuss how breast cancer cells are hunting for specific blood vessels that contain a molecule called E-selectin. (Ref.) This molecule exists in specific blood vessels in bone marrow and this is how cancer cells get there. Once they get there, they enter the tissue inside bones
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Hyaluronic Acid Modulation: Preventing Recurrence or Supporting Other Therapies – Otherwise Better Not

Recently, I was reading this article Why cancer drugs can’t take the pressure, arguing that “A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors.” and that the reason for that is a “naturally occurring molecule called hyaluronic acid, primarily responsible for generating elevated gel-fluid pressures in tumors.”
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Methylglyoxal: Large Response Rate in Very Advanced Stages

Introduction: Methylglyoxal, a molecule also produce by human body, it is one of the substances with an anti cancer potential that stands out. I am enthusiast about it because of the following facts: It has clear science behind supported by a large amount of academic research Its anti cancer potential has been already demonstrated in humans It
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Cholesterol & Cancer: Inhibit ACAT to Kill Aggressive Cancers

Summary: Cholesterol is a lipid molecule present in the membranes of all mammalian cells and is essential for their growth and viability. As an indispensable constituent of plasma membranes, cholesterol affects properties and functions of membrane proteins such as receptors, enzymes, or ion channels. Cells produce cholesterol or are able to draw it from extracellular sources via
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The Anti-Fungal drug Griseofulvin: Like Chemotheraphy but Without its Side Effects

Cellular division: Mitosis is a part of the cell life cycle in which the division of the nucleus takes place so that finally one cell will become two cells. This is the process in which chromosomes in a cell nucleus are separated into two identical sets of chromosomes, and each set ends up in its own nucleus. The
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Propranolol: A “Heart Drug” that Stops Cancer Progression due to Stress

Background: Propranolol is a drug commonly used to treat high blood pressure, irregular heart rhythms, pheochromocytoma (tumor on a small gland near the kidneys), certain types of tremor, and hypertrophic subaortic stenosis (a heart muscle disease). It is also used to prevent angina (chest pain), migraine headaches, and to improve survival after a heart attack.
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Artemisia Annua, Artemisinin & 2015 Nobel Prize in Medicine

Background:  Artemisinin is a natural extract, coming out of a plant called Artemisia annua (sweet wormwood) used as a drug to treat malaria. It saved million of lives so far and as a results, its discoverer Mrs. Tu Youyou received the 2015 Nobel Prize in Physiology or Medicine (Ref.). Its discovery goes back to 1969. While the whole world
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Hippo Pathway: Regulating Organ Size & Cell Proliferation

Background and Mechanism: Interestingly, a few years ago it has been published in Nature magazine a study reporting that glucose, the main energy source used for energy generation in cells, regulates the Hippo pathway (specifically its downstream effector YAP)(Ref.). This is very interesting and ground breaking because with this research it has been indicated for the first time
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Curcumin: A Star in Cancer Treatment Field

Summary: When searching for some of the most effective anti cancer natural extracts accessible, low cost and non toxic, Curcumin will be one of the first we will come across. Curcumin is an extract from Tumernic a yellow-pigmented curry spice that is often used in Indian foods. Curcumin relevance in cancer was so intensively researched so that
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